371 research outputs found
Fragmentation of exotic oxygen isotopes
Abrasion-ablation models and the empirical EPAX parametrization of projectile fragmentation are described. Their cross section predictions are compared to recent data of the fragmentation of secondary beams of neutron-rich, unstable 19,20,21O isotopes at beam energies near 600 MeV/nucleon as well as data for stable 17,18O beams
Pirfenidone in idiopathic pulmonary fibrosis:expert panel discussion on the management of drug-related adverse events
Pirfenidone is currently the only approved therapy for idiopathic pulmonary fibrosis, following studies demonstrating that treatment reduces the decline in lung function and improves progression-free survival. Although generally well tolerated, a minority of patients discontinue therapy due to gastrointestinal and skin-related adverse events (AEs). This review summarizes recommendations based on existing guidelines, research evidence, and consensus opinions of expert authors, with the aim of providing practicing physicians with the specific clinical information needed to educate the patient and better manage pirfenidone-related AEs with continued pirfenidone treatment. The main recommendations to help prevent and/or mitigate gastrointestinal and skin-related AEs include taking pirfenidone during (or after) a meal, avoiding sun exposure, wearing protective clothing, and applying a broad-spectrum sunscreen with high ultraviolet (UV) A and UVB protection. These measures can help optimize AE management, which is key to maintaining patients on an optimal treatment dose.Correction in: Advances in Therapy, Volume 31, Issue 5, pp 575-576 , doi: 10.1007/s12325-014-0118-8</p
Isospin dependent multifragmentation of relativistic projectiles
The N/Z dependence of projectile fragmentation at relativistic energies has
been studied with the ALADIN forward spectrometer at the GSI Schwerionen
Synchrotron (SIS). Stable and radioactive Sn and La beams with an incident
energy of 600 MeV per nucleon have been used in order to explore a wide range
of isotopic compositions. For the interpretation of the data, calculations with
the statistical multifragmentation model for a properly chosen ensemble of
excited sources were performed. The parameters of the ensemble, representing
the variety of excited spectator nuclei expected in a participant-spectator
scenario, are determined empirically by searching for an optimum reproduction
of the measured fragment-charge distributions and correlations. An overall very
good agreement is obtained. The possible modification of the liquid-drop
parameters of the fragment description in the hot freeze-out environment is
studied, and a significant reduction of the symmetry-term coefficient is found
necessary to reproduce the mean neutron-to-proton ratios /Z and the
isoscaling parameters of Z<=10 fragments. The calculations are, furthermore,
used to address open questions regarding the modification of the surface-term
coefficient at freeze-out, the N/Z dependence of the nuclear caloric curve, and
the isotopic evolution of the spectator system between its formation during the
initial cascade stage of the reaction and its subsequent breakup.Comment: 23 pages, 29 figures, published in Physical Review
Gross Properties and Isotopic Phenomena in Spectator Fragmentation
A systematic study of isotopic effects in the break-up of projectile
spectators at relativistic energies has been performed with the ALADiN
spectrometer at the GSI laboratory. Searching for signals of criticality in the
fragment production we have applied the model independent universal
fluctuations theory already proposed to track criticality signals in
multifragmentation to our data. The fluctuation of the largest fragment charge
and of the asymmetry of the two and three largest fragments and their bimodal
distribution have also been analysed.Comment: 6 pages, 4 figures, IX International Conference on Nucleus-Nucleus
Collisions, Rio de Janeiro, Brazil, August 28 - September 1, 200
Discriminant Analysis and Secondary-Beam Charge Recognition
The discriminant-analysis method has been applied to optimize the exotic-beam
charge recognition in a projectile fragmentation experiment. The experiment was
carried out at the GSI using the fragment separator (FRS) to produce and select
the relativistic secondary beams, and the ALADIN setup to measure their
fragmentation products following collisions with Sn target nuclei. The beams of
neutron poor isotopes around 124La and 107Sn were selected to study the isospin
dependence of the limiting temperature of heavy nuclei by comparing with
results for stable 124Sn projectiles. A dedicated detector to measure the
projectile charge upstream of the reaction target was not used, and alternative
methods had to be developed. The presented method, based on the multivariate
discriminant analysis, allowed to increase the efficacy of charge recognition
up to about 90%, which was about 20% more than achieved with the simple scalar
methods.Comment: 6 pages, 7 eps figures, elsart, submitted to Nucl. Instr. and Meth.
Mass and Isospin Effects in Multifragmentation
A systematic study of isospin effects in the breakup of projectile spectators
at relativistic energies has been performed with the ALADiN spectrometer at the
GSI laboratory (Darmstadt). Four different projectiles 197Au, 124La, 124Sn and
107Sn, all with an incident energy of 600 AMeV, have been used, thus allowing a
study of various combinations of masses and N/Z ratios in the entrance channel.
The measurement of the momentum vector and of the charge of all projectile
fragments with Z>1 entering the acceptance of the ALADiN magnet has been
performed with the high efficiency and resolution achieved with the TP-MUSIC IV
detector. The Rise and Fall behavior of the mean multiplicity of IMFs as a
function of Zbound and its dependence on the isotopic composition has been
determined for the studied systems. Other observables investigated so far
include mean N/Z values of the emitted light fragments and neutron
multiplicities. Qualitative agreement has been obtained between the observed
gross properties and the predictions of the Statistical Multifragmentation
Model.Comment: 10 pages,7 figure, 18th Nuclear Physics Division Conference of the
EPS, Prague, submitted to Nucl. Phys.
Neutron recognition in the LAND detector for large neutron multiplicity
The performance of the LAND neutron detector is studied. Using an
event-mixing technique based on one-neutron data obtained in the S107
experiment at the GSI laboratory, we test the efficiency of various analytic
tools used to determine the multiplicity and kinematic properties of detected
neutrons. A new algorithm developed recently for recognizing neutron showers
from spectator decays in the ALADIN experiment S254 is described in detail. Its
performance is assessed in comparison with other methods. The properties of the
observed neutron events are used to estimate the detection efficiency of LAND
in this experiment.Comment: 16 pages, 8 figure
Visual onset expands subjective time
We report a distortion of subjective time perception in which the duration of a first interval is perceived to be longer than the succeeding interval of the same duration. The amount of time expansion depends on the onset type defining the first interval. When a stimulus appears abruptly, its duration is perceived to be longer than when it appears following a stationary array. The difference in the processing time for the stimulus onset and motion onset, measured as reaction times, agrees with the difference in time expansion. Our results suggest that initial transient responses for a visual onset serve as a temporal marker for time estimation, and a systematic change in the processing time for onsets affects perceived time
Seniors' experiences of living in special housing accommodation
This article presents a hermeneutic phenomenological analysis of interview material in which 12 seniors living in Special Housing Accommodation (SHA) facilities reflect on the experience of living in such facilities. Of particular interest in the analysis is living in a SHA as a phenomenon. The finding shows that the phenomenon of lived experience in a SHA seems to be a state of ambiguity regarding one's existence, which is made up of several constituents (elements of meaning). The analysis contributes to the understanding of how the phenomenon of SHA living is coming into existence as a need, due to an individual's failing health; however, the SHA is not considered to be a true home. Accordingly, this has consequences to the subject position for the seniors in that they have to navigate between existing and not existing. The seniors learn to cope with living in the SHA by lowering their expectations of life and existence while the SHA provides the prerequisites for their existence. An implication for promoting care is to support the seniors to enable a full existence of life within SHA living
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