352 research outputs found
TRIS III: the diffuse galactic radio emission at
We present values of temperature and spectral index of the galactic diffuse
radiation measured at 600 and 820 MHz along a 24 hours right ascension circle
at declination . They have been obtained from a subset of
absolute measurements of the sky temperature made with TRIS, an experiment
devoted to the measurement of the Cosmic Microwave Background temperature at
decimetric-wavelengths with an angular resolution of about .
Our analysis confirms the preexisting picture of the galactic diffuse
emission at decimetric wavelength and improves the accuracy of the measurable
quantities. In particular, the signal coming from the halo has a spectral index
in the range above 600 MHz, depending on the sky position. In the
disk, at TRIS angular resolution, the free-free emission accounts for the 11%
of the overall signal at 600 MHz and 21% at 1420 MHz. The polarized component
of the galactic emission, evaluated from the survey by Brouw and Spoelstra,
affects the observations at TRIS angular resolution by less than 3% at 820 MHz
and less than 2% at 600 MHz. Within the uncertainties, our determination of the
galactic spectral index is practically unaffected by the correction for
polarization.
Since the overall error budget of the sky temperatures measured by TRIS at
600 MHz, that is 66 mK(systematic)18 mK (statistical), is definitely smaller
than those reported in previous measurements at the same frequency, our data
have been used to discuss the zero levels of the sky maps at 150, 408, 820 and
1420 MHz in literature. Concerning the 408 MHz survey, limiting our attention
to the patch of sky corresponding to the region observed by TRIS, we suggest a
correction of the base-level of K.Comment: Accepted for publication in the Astrophysical Journa
A high-resolution radio survey of the Vela supernova remnant
This paper presents a high-resolution radio continuum (843 MHz) survey of the
Vela supernova remnant. The contrast between the structures in the central
pulsar-powered nebula of the remnant and the synchrotron radiation shell allows
the remnant to be identified morphologically as a member of the composite
class. The data are the first of a composite remnant at spatial scales
comparable with those available for the Cygnus Loop and the Crab Nebula, and
make possible a comparison of radio, optical and soft X-ray emission from the
resolved shell filaments. The survey, made with the Molonglo Observatory
Synthesis Telescope, covers an area of 50 square degrees at a resolution of
43'' x 60'', while imaging structures on scales up to 30'.Comment: 18 pages, 7 jpg figures (version with ps figures at
http://astro.berkeley.edu/~dbock/papers/); AJ, in pres
New 6cm and 11cm observations of the supernova remnant CTA 1
(Abridged) We conducted new 6cm and 11cm observations of CTA 1 using the
Urumqi 25-m and Effelsberg 100-m telescopes. Data at other wavelengths were
included to investigate the spectrum and polarisation properties. We obtained
new total intensity and polarisation maps at 6cm and 11cm with angular
resolutions of 9.5 arcmin and 4.4 arcmin, respectively. We derived a spectral
index of alpha=-0.63+/-0.05 based on the integrated flux densities at 408 MHz,
1420 MHz, 2639 MHz, and 4800 MHz. The spectral index map calculated from data
at the four frequencies shows a clear steepening of the spectrum from the
strong shell emission towards the north-western breakout region with weak
diffuse emission. The decrease of the spectral index is up to about 0.3. The RM
map derived from polarisation data at 6cm and 11cm shows a sharp transition
between positive RMs in the north-eastern and negative RMs in the south-western
part of the SNR. We note a corresponding RM pattern of extragalactic sources
and propose the existence of a large-diameter Faraday screen in front of CTA 1,
which covers the north-eastern part of the SNR. The RM of the Faraday screen is
estimated to be about +45 rad/m2. A RM structure function of CTA 1 indicates a
very regular magnetic field within the Faraday screen, which is larger than
about 2.7 microG in case of 500 pc distance.Comment: 9 pages, 12 figures, minor changes, accepted for publication in A&
XMMU J0541.8-6659, a new supernova remnant in the Large Magellanic Cloud
The high sensitivity of the XMM-Newton instrumentation offers the opportunity
to study faint and extended sources in the Milky Way and nearby galaxies such
as the Large Magellanic Cloud (LMC) in detail. The ROSAT PSPC survey of the LMC
has revealed more than 700 X-ray sources, among which there are 46 supernova
remnants (SNRs) and candidates. We have observed the field around one of the
most promising SNR candidates in the ROSAT PSPC catalogue, labelled [HP99] 456
with XMM-Newton, to determine its nature. We investigated the XMM-Newton data
along with new radio-continuum, near infrared and optical data. In particular,
spectral and morphological studies of the X-ray and radio data were performed.
The X-ray images obtained in different energy bands reveal two different
structures. Below 1.0 keV the X-ray emission shows the shell-like morphology of
an SNR with a diameter of ~73 pc, one of the largest known in the LMC. For its
thermal spectrum we estimate an electron temperature of (0.49 +/- 0.12)keV
assuming non-equilibrium ionisation. The X-ray images above 1.0 keV reveal a
less extended source within the SNR emission, located ~1' west of the centre of
the SNR and coincident with bright point sources detected in radio-continuum.
This hard component has an extent of 0.9' (i.e. ~13 pc at a distance of ~50
kpc) and a non-thermal spectrum. The hard source coincides in position with the
ROSAT source [HP99] 456 and shows an indication for substructure. We firmly
identify a new SNR in the LMC with a shell-like morphology and a thermal
spectrum. Assuming the SNR to be in the Sedov phase yields an age of ~23 kyr.
We explore possible associations of the hard non-thermal emitting component
with a pulsar wind nebula (PWN) or background active galactic nuclei (AGN).Comment: 8 pages, 7 figures, accepted for publication in Astronomy and
Astrophysic
Reversible Induction of Phantom Auditory Sensations through Simulated Unilateral Hearing Loss
Tinnitus, a phantom auditory sensation, is associated with hearing loss in most cases, but it is unclear if hearing loss causes tinnitus. Phantom auditory sensations can be induced in normal hearing listeners when they experience severe auditory deprivation such as confinement in an anechoic chamber, which can be regarded as somewhat analogous to a profound bilateral hearing loss. As this condition is relatively uncommon among tinnitus patients, induction of phantom sounds by a lesser degree of auditory deprivation could advance our understanding of the mechanisms of tinnitus. In this study, we therefore investigated the reporting of phantom sounds after continuous use of an earplug. 18 healthy volunteers with normal hearing wore a silicone earplug continuously in one ear for 7 days. The attenuation provided by the earplugs simulated a mild high-frequency hearing loss, mean attenuation increased from <10 dB at 0.25 kHz to >30 dB at 3 and 4 kHz. 14 out of 18 participants reported phantom sounds during earplug use. 11 participants presented with stable phantom sounds on day 7 and underwent tinnitus spectrum characterization with the earplug still in place. The spectra showed that the phantom sounds were perceived predominantly as high-pitched, corresponding to the frequency range most affected by the earplug. In all cases, the auditory phantom disappeared when the earplug was removed, indicating a causal relation between auditory deprivation and phantom sounds. This relation matches the predictions of our computational model of tinnitus development, which proposes a possible mechanism by which a stabilization of neuronal activity through homeostatic plasticity in the central auditory system could lead to the development of a neuronal correlate of tinnitus when auditory nerve activity is reduced due to the earplug
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Background: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. Methods: We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. Findings: Between June 17, 2020, and April 14, 2021, 47 795 (75·2%) of 63 525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11 185 [86·6%] of 12 909 vs 36 415 [72·4%] of 50 278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70–0·89], p=0·0001, for 70–79 years; 0·52 [0·46–0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75–80% in January, 2021. Interpretation: Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. Funding: UK National Institute for Health Research and UK Medical Research Council
Radio emission from Supernova Remnants
The explosion of a supernova releases almost instantaneously about 10^51 ergs
of mechanic energy, changing irreversibly the physical and chemical properties
of large regions in the galaxies. The stellar ejecta, the nebula resulting from
the powerful shock waves, and sometimes a compact stellar remnant, constitute a
supernova remnant (SNR). They can radiate their energy across the whole
electromagnetic spectrum, but the great majority are radio sources. Almost 70
years after the first detection of radio emission coming from a SNR, great
progress has been achieved in the comprehension of their physical
characteristics and evolution. We review the present knowledge of different
aspects of radio remnants, focusing on sources of the Milky Way and the
Magellanic Clouds, where the SNRs can be spatially resolved. We present a brief
overview of theoretical background, analyze morphology and polarization
properties, and review and critical discuss different methods applied to
determine the radio spectrum and distances. The consequences of the interaction
between the SNR shocks and the surrounding medium are examined, including the
question of whether SNRs can trigger the formation of new stars. Cases of
multispectral comparison are presented. A section is devoted to reviewing
recent results of radio SNRs in the Magellanic Clouds, with particular emphasis
on the radio properties of SN 1987A, an ideal laboratory to investigate
dynamical evolution of an SNR in near real time. The review concludes with a
summary of issues on radio SNRs that deserve further study, and analyzing the
prospects for future research with the latest generation radio telescopes.Comment: Revised version. 48 pages, 15 figure
Novel Serial Positive Enrichment Technology Enables Clinical Multiparameter Cell Sorting
A general obstacle for clinical cell preparations is limited purity, which causes variability in the quality and potency of cell products and might be responsible for negative side effects due to unwanted contaminants. Highly pure populations can be obtained best using positive selection techniques. However, in many cases target cell populations need to be segregated from other cells by combinations of multiple markers, which is still difficult to achieve – especially for clinical cell products. Therefore, we have generated low-affinity antibody-derived Fab-fragments, which stain like parental antibodies when multimerized via Strep-tag and Strep-Tactin, but can subsequently be removed entirely from the target cell population. Such reagents can be generated for virtually any antigen and can be used for sequential positive enrichment steps via paramagnetic beads. First protocols for multiparameter enrichment of two clinically relevant cell populations, CD4high/CD25high/CD45RAhigh ‘regulatory T cells’ and CD8high/CD62Lhigh/CD45RAneg ‘central memory T cells’, have been established to determine quality and efficacy parameters of this novel technology, which should have broad applicability for clinical cell sorting as well as basic research
SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus [version 2; peer review: 2 approved]
Background: Laboratory diagnosis of SARS-CoV-2 infection (the cause of COVID-19) uses PCR to detect viral RNA (vRNA) in respiratory samples. SARS-CoV-2 RNA has also been detected in other sample types, but there is limited understanding of the clinical or laboratory significance of its detection in blood. Methods: We undertook a systematic literature review to assimilate the evidence for the frequency of vRNA in blood, and to identify associated clinical characteristics. We performed RT-PCR in serum samples from a UK clinical cohort of acute and convalescent COVID-19 cases (n=212), together with convalescent plasma samples collected by NHS Blood and Transplant (NHSBT) (n=462 additional samples). To determine whether PCR-positive blood samples could pose an infection risk, we attempted virus isolation from a subset of RNA-positive samples. Results: We identified 28 relevant studies, reporting SARS-CoV-2 RNA in 0-76% of blood samples; pooled estimate 10% (95%CI 5-18%). Among serum samples from our clinical cohort, 27/212 (12.7%) had SARS-CoV-2 RNA detected by RT-PCR. RNA detection occurred in samples up to day 20 post symptom onset, and was associated with more severe disease (multivariable odds ratio 7.5). Across all samples collected ≥28 days post symptom onset, 0/494 (0%, 95%CI 0-0.7%) had vRNA detected. Among our PCR-positive samples, cycle threshold (ct) values were high (range 33.5-44.8), suggesting low vRNA copy numbers. PCR-positive sera inoculated into cell culture did not produce any cytopathic effect or yield an increase in detectable SARS-CoV-2 RNA. There was a relationship between RT-PCR negativity and the presence of total SARS-CoV-2 antibody (p=0.02). Conclusions: vRNA was detectable at low viral loads in a minority of serum samples collected in acute infection, but was not associated with infectious SARS-CoV-2 (within the limitations of the assays used). This work helps to inform biosafety precautions for handling blood products from patients with current or previous COVID-19
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