Latency and accuracy optimized mobile face detection

Abstract. Face detection is a preprocessing step in many computer vision applications. Important factors are accuracy, inference duration, and energy efficiency of the detection framework. Computationally light detectors that execute in real-time are a requirement for many application areas, such as face tracking and recognition. Typical operating platforms in everyday use are smartphones and embedded devices, which have limited computation capacity. The capability of face detectors is comparable to the ability of a human in easy detection tasks. When the conditions change, the challenges become different. Current challenges in face detection include atypically posed and tiny faces. Partially occluded faces and dim or bright environments pose challenges for detection systems. State-of-the-art performance in face detection research employs deep learning methods called neural networks, which loosely imitate the mammalian brain system. The most relevant technologies are convolutional neural networks, which are designed for local feature description. In this thesis, the main computational optimization approach is neural network quantization. The network models were delegated to digital signal processors and graphics processing units. Quantization was shown to reduce the latency of computation substantially. The most energy-efficient inference was achieved through digital signal processor delegation. Multithreading was used for inference acceleration. It reduced the amount of energy consumption per algorithm run.Latenssi- ja tarkkuusoptimoitu kasvontunnistus mobiililaitteilla. Tiivistelmä. Kasvojen ilmaisu on esikäsittelyvaihe monelle konenäön sovellukselle. Tärkeitä kasvoilmaisimen ominaisuuksia ovat tarkkuus, energiatehokkuus ja suoritusnopeus. Monet sovellukset vaativat laskennallisesti kevyitä ilmaisimia, jotka toimivat reaaliajassa. Esimerkkejä sovelluksista ovat kasvojen seuranta- ja tunnistusjärjestelmät. Yleisiä käyttöalustoja ovat älypuhelimet ja sulautetut järjestelmät, joiden laskentakapasiteetti on rajallinen. Kasvonilmaisimien tarkkuus vastaa ihmisen kykyä helpoissa ilmaisuissa. Nykyiset ongelmat kasvojen ilmaisussa liittyvät epätyypillisiin asentoihin ja erityisen pieniin kasvokokoihin. Myös kasvojen osittainen peittyminen, ja pimeät ja kirkkaat ympäristöt, vaikeuttavat ilmaisua. Neuroverkkoja käytetään tekoälyjärjestelmissä, joiden lähtökohtana on ollut mallintaa nisäkkäiden aivojen toimintaa. Konvoluutiopohjaiset neuroverkot ovat erikoistuneet paikallisten piirteiden analysointiin. Tässä opinnäytetyössä käytetty laskennallisen optimoinnin menetelmä on neuroverkkojen kvantisointi. Neuroverkkojen ajo delegoitiin digitaalisille signaalinkäsittely- ja grafiikkasuorittimille. Kvantisoinnin osoitettiin vähentävän laskenta-aikaa huomattavasti ja suurin energiatehokkuus saavutettiin digitaalisen signaaliprosessorin avulla. Suoritusnopeutta lisättiin monisäikeistyksellä, jonka havaittiin vähentävän energiankulutusta

Cognitive Effects of White Matter Pathology in Normal and Pathological Aging

We examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer's disease (total n = 149), controlling for age and education. Trend-level effects of white matter pathology on cognition were only observed in patients with Alzheimer's disease (p = 0.062, eta(2) = 0.052), patients with severe frontal white matter pathology performed notably worse than those with milder pathology. This indicates that frontal cerebrovascular pathology may have an additive negative effect on cognition in Alzheimer's disease

Prospective study on the effect of short-term androgen deprivation therapy on PSMA uptake evaluated with 68Ga-PSMA-11 PET/MRI in men with treatment-naïve prostate cancer

PURPOSE: Based on in vitro studies, it is known that androgen deprivation therapy (ADT) increases prostate-specific membrane antigen (PSMA) expression. Therefore, we hypothesised that ADT improves the performance of PSMA-PET imaging in primary staging of prostate cancer. The purpose of the study was to demonstrate the time course effect of ADT on PSMA uptake in different types of metastatic lesions evaluated with 68Ga-PSMA-11 PET/MRI.METHODS: Nine men with treatment-naïve prostate cancer were enrolled to a prospective, registered (NCT03313726) clinical trial. A 68Ga-PSMA-11 PET/MRI was performed once before and 3 times post-ADT (degarelix, Firmagon). Change of maximum standardised uptake values (SUVmax) in prostate, lymph nodes, bone metastases, and physiologically PSMA-avid organs were evaluated in a time frame of 1-8 weeks.RESULTS: All patients reached castration levels within 10 days, and 50% decrease in prostate-specific antigen (PSA) concentration was observed 14 days post-ADT. A heterogeneous increase in PSMA uptake was observed 3 to 4 weeks post-ADT. This phenomenon was definitively more evident in bone metastases: 13 (57%) of the metastasis, with a mean (range) SUVmax increase of 77% (8-238%). In one patient, already having bone metastases at baseline, three new bone metastases were observed post-ADT. Of lesions with reduced SUVmax, none disappeared.CONCLUSIONS: Both in patient and region level, increase in PSMA uptake post-ADT is heterogenous and is seen most evidently in bone metastases. Preliminary results on a small cohort of patients suggest the clinical impact of ADT on improving the performance of 68Ga-PSMA PET in staging seems to be minor. However, the optimal imaging time point might be 3 to 4 weeks post-ADT. Since none of the metastases with decreasing SUVmax disappeared, it seems that short-term usage of ADT does not interfere with the interpretation of 68Ga-PSMA PET.TRIAL REGISTRATION: NCT03313726, registered 18 October 2017; EUDRA-CT, 2017-002345-29.</p

Weaning practices in phenylketonuria vary between health professionals in Europe

Background: In phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage L-amino acid supplement is usually recommended from around 6 months to replace Phe-free infant formula. Our aim was to assess different weaning approaches used by health professionals across Europe. Methods: A cross sectional questionnaire (survey monkey (R)) composed of 31 multiple and single choice questions was sent to European colleagues caring for inherited metabolic disorders (IMD). Centres were grouped into geographical regions for analysis. Results: Weaning started at 17-26 weeks in 85% (n=81/95) of centres, > 26 weeks in 12% (n=11/95) and 26 weeks. First solids were mainly low Phe vegetables (59%, n=56/95) and fruit (34%, n=32/95). A Phe exchange system to allocate dietary Phe was used by 52% (n=49/95) of centres predominantly from Northern and Southern Europe and 48% (n=46/95) calculated most Phe containing food sources (all centres in Eastern Europe and the majority from Germany and Austria). Some centres used a combination of both methods. A second stage Phe-free L-amino acid supplement containing a higher protein equivalent was introduced by 41% (n=39/95) of centres at infant age 26-36 weeks (mainly from Germany, Austria, Northern and Eastern Europe) and 37% (n=35/95) at infant age > 1y mainly from Southern Europe. 53% (n=50/95) of centres recommended a second stage Phe-free L-amino acid supplement in a spoonable or semi-solid form. Conclusions: Weaning strategies vary throughout European PKU centres. There is evidence to suggest that different infant weaning strategies may influence longer term adherence to the PKU diet or acceptance of Phe-free L-amino acid supplements; rendering prospective long-term studies important. It is essential to identify an effective weaning strategy that reduces caregiver burden but is associated with acceptable dietary adherence and optimal infant feeding development.Peer reviewe

Early feeding practices in infants with phenylketonuria across Europe

Background: In infants with phenylketonuria (PKU), dietary management is based on lowering and titrating phenylalanine (Phe) intake from breast milk or standard infant formula in combination with a Phe-free infant formula in order to maintain blood Phe levels within target range. Professionals use different methods to feed infants with PKU and our survey aimed to document practices across Europe. Methods: We sent a cross sectional, survey monkey (R) questionnaire to European health professionals working in IMD. It contained 31 open and multiple-choice questions. The results were analysed according to different geographical regions. Results: Ninety-five centres from 21 countries responded. Over 60% of centres commenced diet in infants by age 10 days, with 58% of centres implementing newborn screening by day 3 post birth. At diagnosis, infant hospital admission occurred in 61% of metabolic centres, mainly in Eastern, Western and Southern Europe. Breastfeeding fell sharply following diagnosis with only 30% of women still breast feeding at 6 months. 53% of centres gave pre-measured Phe-free infant formula before each breast feed and 23% alternated breast feeds with Phe-free infant formula. With standard infant formula feeds, measured amounts were followed by Phe-free infant formula to satiety in 37% of centres (n = 35/95), whereas 44% (n = 42/95) advised mixing both formulas together. Weaning commenced between 17 and 26 weeks in 85% centres, >= 26 weeks in 12% and <17 weeks in 3%. Discussion: This is the largest European survey completed on PKU infant feeding practices. It is evident that practices varied widely across Europe, and the practicalities of infant feeding in PKU received little focus in the PKU European Guidelines (2017). There are few reports comparing different feeding techniques with blood Phe control, Phe fluctuations and growth. Controlled prospective studies are necessary to assess how different infant feeding practices may influence longer term feeding development.Peer reviewe