Контрастивний аспекту вивченні фразеологічних одиниць із компонентом вогонь (на матеріалі української та англійської мов)

(uk) У статті проведено контрастивный аналіз фразеологізмів із компонентом «вогонь» в українській та англійській мовах, а також визначено, що він відіграє першочергову роль у формуванні фразеологічного значення, оскільки виступає у ролі мотивуючого компонента семантики аналізованих фразеологізмів. У всіх досліджуваних одиницях української та англійської мов компонент «вогонь» сигналізує сему «смерть», іноді — «очищення», «витримка».(en) The article deals with the contrastive analysis of phraseological units with the component ‘fire’ in Ukrainian and English. It is found out that it plays a primary role in shaping the idiomatic meaning as a motivating component of semantics of the analyzed idioms. In all Ukrainian and English units with the component ‘fire’ it implies the seme ‘death’, or sometimes ‘cleaning’, ‘endurance’

The dynamic interest in topics within the biomedical scientific community

Peer reviewe

Spectral analysis of boundary layers in Rayleigh-Benard convection

A combined experimental and numerical study of the boundary layer in a 4:1 aspect-ratio Rayleigh-B\'{e}nard cell over a four-decade range of Rayleigh numbers has been undertaken aimed at gaining a better insight into the character of the boundary layers. The experiments involved the simultaneous Laser Doppler Anemometry (LDA) measurements of fluid velocity at two locations, i.e. in the boundary layer and far away from it in the bulk, for Rayleigh numbers varying between $1.6 \times 10^7$ and $2.4 \times 10^9$. In parallel, direct numerical simulations (DNS) have been performed for the same configuration for Rayleigh numbers between $7.0 \times 10^4$ and $7.7 \times 10^7$. The temperature and velocity probability density functions and the power spectra of the horizontal velocity fluctuations measured in the boundary layer and in the bulk flow are found to be practically identical. Except for the smallest Rayleigh numbers, the spectra in the boundary layer and in the bulk central region are continuous and have a wide range of active scales. This indicates that both the bulk and the boundary layers are turbulent in the $\textrm{Ra}$ number range considered. However, molecular effects can still be observed and the boundary layer does not behave like a classical shear-driven turbulent boundary layer.Comment: 10 pages, 6 figures, Accepted for publication in Phys. Rev.

BCL11B Regulates Epithelial Proliferation and Asymmetric Development of the Mouse Mandibular Incisor

Mouse incisors grow continuously throughout life with enamel deposition uniquely on the outer, or labial, side of the tooth. Asymmetric enamel deposition is due to the presence of enamel-secreting ameloblasts exclusively within the labial epithelium of the incisor. We have previously shown that mice lacking the transcription factor BCL11B/CTIP2 (BCL11B hereafter) exhibit severely disrupted ameloblast formation in the developing incisor. We now report that BCL11B is a key factor controlling epithelial proliferation and overall developmental asymmetry of the mouse incisor: BCL11B is necessary for proliferation of the labial epithelium and development of the epithelial stem cell niche, which gives rise to ameloblasts; conversely, BCL11B suppresses epithelial proliferation, and development of stem cells and ameloblasts on the inner, or lingual, side of the incisor. This bidirectional action of BCL11B in the incisor epithelia appears responsible for the asymmetry of ameloblast localization in developing incisor. Underlying these spatio-specific functions of BCL11B in incisor development is the regulation of a large gene network comprised of genes encoding several members of the FGF and TGFβ superfamilies, Sprouty proteins, and Sonic hedgehog. Our data integrate BCL11B into these pathways during incisor development and reveal the molecular mechanisms that underlie phenotypes of both Bcl11b−/− and Sprouty mutant mice

Body Composition Is a Predictor for Postoperative Complications After Gastrectomy for Gastric Cancer:a Prospective Side Study of the LOGICA Trial

PURPOSE: There is a lack of prospective studies evaluating the effects of body composition on postoperative complications after gastrectomy in a Western population with predominantly advanced gastric cancer. METHODS: This is a prospective side study of the LOGICA trial, a multicenter randomized trial on laparoscopic versus open gastrectomy for gastric cancer. Trial patients who received preoperative chemotherapy followed by gastrectomy with an available preoperative restaging abdominal computed tomography (CT) scan were included. The CT scan was used to calculate the mass (M) and radiation attenuation (RA) of skeletal muscle (SM), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). These variables were expressed as Z-scores, depicting how many standard deviations each patient’s CT value differs from the sex-specific study sample mean. Primary outcome was the association of each Z-score with the occurrence of a major postoperative complication (Clavien-Dindo grade ≥ 3b). RESULTS: From 2015 to 2018, a total of 112 patients were included. A major postoperative complication occurred in 9 patients (8%). A high SM-M Z-score was associated with a lower risk of major postoperative complications (RR 0.47, 95% CI 0.28–0.78, p = 0.004). Furthermore, high VAT-RA Z-scores and SAT-RA Z-scores were associated with a higher risk of major postoperative complications (RR 2.82, 95% CI 1.52–5.23, p = 0.001 and RR 1.95, 95% CI 1.14–3.34, p = 0.015, respectively). VAT-M, SAT-M, and SM-RA Z-scores showed no significant associations. CONCLUSION: Preoperative low skeletal muscle mass and high visceral and subcutaneous adipose tissue radiation attenuation (indicating fat depleted of triglycerides) were associated with a higher risk of developing a major postoperative complication in patients treated with preoperative chemotherapy followed by gastrectomy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11605-022-05321-0

Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.

Advances in precision molecular imaging promise to transform our ability to detect, diagnose and treat disease. Here, we describe the engineering and validation of a new cystine knot peptide (knottin) that selectively recognizes human integrin αvβ6 with single-digit nanomolar affinity. We solve its 3D structure by NMR and x-ray crystallography and validate leads with 3 different radiolabels in pre-clinical models of cancer. We evaluate the lead tracer's safety, biodistribution and pharmacokinetics in healthy human volunteers, and show its ability to detect multiple cancers (pancreatic, cervical and lung) in patients at two study locations. Additionally, we demonstrate that the knottin PET tracers can also detect fibrotic lung disease in idiopathic pulmonary fibrosis patients. Our results indicate that these cystine knot PET tracers may have potential utility in multiple disease states that are associated with upregulation of integrin αvβ6