Implementation of Basic Principles of Econometric Analysis in Petroleum Technology: A Review of the Econometric Evidence

In the present study we give the opportunity to understand the physicochemical parameters of distilling petroleum products applying the basic principles of econometric analysis. The quality of the different fuels is expressed by a series of physical, chemical or other characteristics. The connection between production process and quality of fuel is crucial in the field of petroleum technology. It is remarkable that the used method of the regression analysis perfectly illustrates the relationships between the variables in all applied models. Econometrics is one the best methods to study the variation of the physicochemical properties of the oil. The use of econometrics methods in petroleum chemistry turned out to be useful tool in order to prove that there is indeed strong rates volatility and correlation between physicochemical properties of oils with their mixes. In Petroleum Industry the most common types of Diesel fuels are the biodiesel, biomass to liquid or gas to liquid Diesel. The results of our research can be an important tool for the development of software that can anticipate changes of physicochemical properties of petroleum distillate products, taking into account specific parameters

The role of polycyclic frameworks in modulating P2X<inf>7</inf> receptor function

Herein we describe our recent attempts to target the P2X7 receptor for potential treatment of neurological disorders. This work focusses on different polycycles including carborane, adamantane or cubane, joined by either a cyanoguanidine or an amide linker to phenyl or isoquinoline moieties. We have demonstrated the superiority of the adamantyl moiety over other polycycles in terms of synthetic accessibility and biological (cellular) activity. We have also shown that an amide or cyanoguanidine linker can greatly alter the biological activity of compounds. This SAR study provides important insights into the types of functionality required to target the P2X7 receptor

Heparin mimetics with anticoagulant activity

Heparin, a sulfated polysaccharide belonging to the glycosaminoglycan family, has been widely used as an anticoagulant drug for decades and remains the most commonly used parenteral anticoagulant in adults and children. However, heparin has important clinical limitations and is derived from animal sources which pose significant safety and supply problems. The ever growing shortage of the raw material for heparin manufacturing may become a very significant issue in the future. These global limitations have prompted much research, especially following the recent well-publicized contamination scandal, into the development of alternative anticoagulants derived from non-animal and/or totally synthetic sources that mimic the structural features and properties of heparin. Such compounds, termed heparin mimetics, are also needed as anticoagulant materials for use in biomedical applications (e.g., stents, grafts, implants etc.). This review encompasses the development of heparin mimetics of various structural classes, including synthetic polymers and non-carbohydrate small molecules as well as sulfated oligo- and polysaccharides, and fondaparinux derivatives and conjugates, with a focus on developments in the past 10 years

Open is not enough

The solutions adopted by the high-energy physics community to foster reproducible research are examples of best practices that could be embraced more widely. This first experience suggests that reproducibility requires going beyond openness

Open is not enough

The solutions adopted by the high-energy physics community to foster reproducible research are examples of best practices that could be embraced more widely. This first experience suggests that reproducibility requires going beyond openness.Peer reviewe

OPERA tau neutrino charged current interactions

The OPERA experiment was designed to discover the v(tau) appearance in a v(mu) beam, due to neutrino oscillations. The detector, located in the underground Gran Sasso Laboratory, consisted of a nuclear photographic emulsion/lead target with a mass of about 1.25 kt, complemented by electronic detectors. It was exposed from 2008 to 2012 to the CNGS beam: an almost pure v(mu) beam with a baseline of 730 km, collecting a total of 1.8 center dot 10(20) protons on target. The OPERA Collaboration eventually assessed the discovery of v(mu)-> v(tau) oscillations with a statistical significance of 6.1 sigma by observing ten v(tau) CC interaction candidates. These events have been published on the Open Data Portal at CERN. This paper provides a ydetailed description of the v(tau) data sample to make it usable by the whole community