Standardization in the European Information and Technology Sector: Official Procedures on the Verge of Being Overhauled

As the European Commission pushes for a reform of traditional procedures in the Information and Communications Technology (“ICT”) sector, the standardization process is intensely debated on the European Union level. This Article provides a concise overview of the past and future European Union policies on ICT standardization and the issues such policies raise

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection

The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase. Natural killer (NK) and NKT cells play an important role in the immune control of T. cruzi infection, mainly by releasing the cytokine IFN-gamma that activates the microbicidal action of macrophages and other cells and shapes a protective type 1 immune response. The mechanisms by which immune cells are regulated to produce IFN-gamma during T. cruzi infection are still incompletely understood. Here, we show that urokinase plasminogen activator (uPA) is induced early upon T. cruzi infection and remains elevated until day 20 post-infection. We previously demonstrated that the inhibitory receptor Ly49E, which is expressed, among others, on NK and NKT cells, is triggered by uPA. Therefore, we compared wild type (WT) to Ly49E knockout (KO) mice for their control of experimental T. cruzi infection. Our results show that young, i.e., 4- and 6-week-old, Ly49E KO mice control the infection better than WT mice, indicated by a lower parasite load and less cachexia. The beneficial effect of Ly49E depletion is more obvious in 4- week-old male than in female mice and weakens in 8-week-old mice. In young mice, the lower T. cruzi parasitemia in Ly49E KO mice is paralleled by higher IFN-gamma production compared to their WT controls. Our data indicate that Ly49E receptor expression inhibits the immune control of T. cruzi infection. This is the first demonstration that the inhibitory Ly49E receptor can interfere with the immune response to a pathogen in vivo

NUSIMEP-7: Uranium isotope amount ratios in uranium particles

The Additional Protocol (AP) authorizes safeguards authorities to verify the absence of undeclared nuclear activities in all parts of a state’s nuclear fuel cycle as well as any other location where nuclear material is or may be present. As part of the Additional Protocol, environmental sampling has become an important tool for the detection of non-declared nuclear activities. In environmental sampling micrometer-sized uranium particles with an isotopic composition characteristic for the processes at the inspected facility need to be collected, identified and analysed. Considering the potential consequences of the analyses, these measurements need to be subjected to a rigorous quality management system. NUSIMEP-7 focused on measurements of uranium isotope amount ratios in uranium particles aiming to support laboratories involved in uranium particle analysis. It was the second NUSIMEP on particle analysis coordinated by IRMM. NUSIMEP-7 was open for participation to all laboratories in the field of particle analysis, particularly also to the IAEA network of analytical laboratories for environmental sampling (NWAL). The NUSIMEP test samples were prepared by controlled hydrolysis of well certified uranium hexafluoride. Participating laboratories in NUSIMEP-7 received the test samples of uranium particles on two graphite disks with undisclosed isotope amount ratio values n(234U)/n(238U), n(235U)/n(238U) and n(236U)/n(238U). The uranium isotope amount ratios had to be measured using their routine analytical procedures. Measurement of the major ratio n(235U)/n(238U) was obligatory; measurement of the minor ratios n(234U)/n(238U) and n(236U)/n(238U) were optional. 24 institutes registered for NUSIMEP-7, whereof 17 have reported measurement results using different analytical methods, among those were 7 NWAL laboratories. The participants’ measurement results have been evaluated against the certified reference values in compliance with ISO 13528:2005. The results of NUSIMEP-7 confirm the capability of laboratories in measuring n(234U)/n(238U), n(235U)/n(238U) and n(236U)/n(238U) in uranium particles of <1 µm. Furthermore they underpin the recent advances in instrumental techniques in the field of particle analysis. In addition feedback from the measurement communities from nuclear safeguards, nuclear security and earth sciences was collected in view of identifying future needs for NUSIMEP interlaboratory comparisons.JRC.D.2-Reference material

Automatically detect diagnostic patterns based on clinical notes through Text Mining

The importance of standardized treatment for patients is huge because it can reduce waiting times, costs in hospitals and make treatment more effective for patients. According to these patterns, the creation of a tool that can make the admission and interpretation of free text will become an important step in the medical field. For the analysis of the unstructured text, the "RapidMiner" tool was used. Following the text analysis, the word frequency technique will be used in the reports and the respective word counts, as well as the cluster analysis that allows the creation of combinations of words. For the modeling we used several Text Mining techniques focused on the main algorithms, since these are properly scientifically proven and that, normally, they are able to obtain better results. (C) 2019 The Authors. Published by Elsevier B.V.This work has been supported by national funds through FCT -Fundacao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2019 and Deus ex Machina (DEM): Symbiotic technology for societal efficiency gains -NORTE-01-0145-FEDER-000026

Text Analytics for Android Project

Most advanced text analytics and text mining tasks include text classification, text clustering, building ontology, concept/entity extraction, summarization, deriving patterns within the structured data, production of granular taxonomies, sentiment and emotion analysis, document summarization, entity relation modelling, interpretation of the output. Already existing text analytics and text mining cannot develop text material alternatives (perform a multivariant design), perform multiple criteria analysis, automatically select the most effective variant according to different aspects (citation index of papers (Scopus, ScienceDirect, Google Scholar) and authors (Scopus, ScienceDirect, Google Scholar), Top 25 papers, impact factor of journals, supporting phrases, document name and contents, density of keywords), calculate utility degree and market value. However, the Text Analytics for Android Project can perform the aforementioned functions. To the best of the knowledge herein, these functions have not been previously implemented; thus this is the first attempt to do so. The Text Analytics for Android Project is briefly described in this article

Can medio-lateral baseplate position and load sharing induce asymptomatic local bone resorption of the proximal tibia? A finite element study

info:eu-repo/semantics/publishe

Certification of the uranium hexafluoride (UF6) isotopic composition: The IRMM-019 to IRMM-029 series

This report describes the re-determination and certification of the IRMM-019 to IRMM-029 series of uranium hexafluoride (UF6) reference materials certified for the uranium isotopic composition. The values were assigned following ISO Guide 34:2009. The IRMM-019 to IRMM-029 series was originally produced and certified in the 1980's-1990's. Since, the materials are stored in monel ampoules. Upon customer request, UF6 gas is distilled from a mother ampoule into a daughter ampoule, the isotopic composition is verified by Gas Source Mass Spectrometry (GSMS) and the daughter ampoule is sent to the customer. For the purpose of this project, the UF6 materials were converted into uranium nitrate solutions to perform the homogeneity and characterisation studies. Between-unit homogeneity was quantified and stability during dispatch and storage were assessed in accordance with ISO Guide 35:2006. The materials were characterised by Thermal Ionisation Mass Spectrometry (TIMS) using newly established measurement procedures such as the Modified Total Evaporation (MTE) and Double Spike (DS) methods, and with a new set of certified uranium isotope reference materials, which were prepared by gravimetrical mixing of highly enriched 233U, 235U, 236U and 238U oxides or solutions. The results of the characterisation measurements were also confirmed by GSMS measurements using the original UF6 gases. Uncertainties of the certified values were estimated in compliance with the Guide to the Expression of Uncertainty in Measurement (GUM) and include uncertainties related to the characterisation measurements and the homogeneity study. The materials are intended for the calibration of methods, quality control purposes, and the assessment of method performance for isotope mass spectrometry. As with any certified reference material, they can also be used for validation studies. The CRMs are available in monel ampoules. Based on physical reasons, there is no minimum sample intake to be taken into account.JRC.D.2-Standards for Innovation and sustainable Developmen

Menstrual management in communal sanitation facilities: recommendations to eThekwini municipality

A growing body of research has shown that menstrual hygiene products (MHPs) are critical to gender equity, and South Africa has committed to providing free sanitary napkins to all indigent women. To address interim water and sanitation needs of its citizens living in informal settlements, South Africa’s eThekwini Water and Sanitation Unit (EWS) constructed community ablution blocks (CABs) that consist of gender-separated toilets, showers, and washbasins. The interactions between women, unfamiliar sanitation systems, and MHPs are likely to impact women and the sanitation systems they utilize. A larger case study led by PATH is evaluating these interactions, within which this sub-study aims to characterize the relationship between CABs and menstrual hygiene management in Durban’s informal settlements. Based on analysis of information gathered through interviews, photo documentation, and observations, we provide recommendations to EWS that we believe will improve women’s experiences at CABs and reduce negative impacts on the sanitation systems