145 research outputs found
FUTURE (Fully aUtonomous feaTUre Recognition planetary Explorer) - Revolutionizing Nanosatellite Autonomy through Visual Navigation
Clinical Study Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients
Objective. Immunoglobulin-G4-(IgG4-) related disease (IgG4 RD) is a fibrosing process characterized by a significant infiltration of IgG4-secreting plasma cells. IgG4 RD can affect almost all organs including salivary glands. Whether IgG4 RD plays a role in the development of sicca syndrome and particularly dry mouth syndrome remains to be investigated. Methods. We conducted a monocentric cohort study for two years to search for IgG4 RD features in patients with dry mouth syndrome using immunostainings of labial salivary gland specimens with anti-IgG4 antibody. Results. Among 60 patients presenting with dry mouth syndrome who underwent labial salivary gland biopsy, 18 showed positive immunostaining with the anti-IgG4 antibody including 4 patients with typical systemic IgG4 RD. Five also fulfilled criteria for Sjögren's syndrome. Conclusion. These findings suggest that clinical forms of IgG4 RD salivary involvement without salivary swelling may occur. This salivary involvement is probably overlooked in everyday practice and could represent a mild form of IgG4 RD
Clinical Study Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients
Objective. Immunoglobulin-G4-(IgG4-) related disease (IgG4 RD) is a fibrosing process characterized by a significant infiltration of IgG4-secreting plasma cells. IgG4 RD can affect almost all organs including salivary glands. Whether IgG4 RD plays a role in the development of sicca syndrome and particularly dry mouth syndrome remains to be investigated. Methods. We conducted a monocentric cohort study for two years to search for IgG4 RD features in patients with dry mouth syndrome using immunostainings of labial salivary gland specimens with anti-IgG4 antibody. Results. Among 60 patients presenting with dry mouth syndrome who underwent labial salivary gland biopsy, 18 showed positive immunostaining with the anti-IgG4 antibody including 4 patients with typical systemic IgG4 RD. Five also fulfilled criteria for Sjögren's syndrome. Conclusion. These findings suggest that clinical forms of IgG4 RD salivary involvement without salivary swelling may occur. This salivary involvement is probably overlooked in everyday practice and could represent a mild form of IgG4 RD
MAGIC Upper Limits for two Milagro-detected, Bright Fermi Sources in the Region of SNR G65.1+0.6
We report on the observation of the region around supernova remnant G65.1+0.6
with the stand-alone MAGIC-I telescope. This region hosts the two bright GeV
gamma-ray sources 1FGL J1954.3+2836 and 1FGL J1958.6+2845. They are identified
as GeV pulsars and both have a possible counterpart detected at about 35 TeV by
the Milagro observatory. MAGIC collected 25.5 hours of good quality data, and
found no significant emission in the range around 1 TeV. We therefore report
differential flux upper limits, assuming the emission to be point-like (<0.1
deg) or within a radius of 0.3 deg. In the point-like scenario, the flux limits
around 1 TeV are at the level of 3 % and 2 % of the Crab Nebula flux, for the
two sources respectively. This implies that the Milagro emission is either
extended over a much larger area than our point spread function, or it must be
peaked at energies beyond 1 TeV, resulting in a photon index harder than 2.2 in
the TeV band.Comment: 8 pages, 3 figures, 1 tabl
Simultaneous multi-frequency observation of the unknown redshift blazar PG 1553+113 in March-April 2008
The blazar PG 1553+113 is a well known TeV gamma-ray emitter. In this paper,
we determine its spectral energy distribution using simultaneous
multi-frequency data in order to study its emission processes. An extensive
campaign was carried out between March and April 2008, where optical, X-ray,
high-energy (HE) gamma-ray, and very-high-energy (VHE) gamma-ray data were
obtained with the KVA, Abastumani, REM, RossiXTE/ASM, AGILE and MAGIC
telescopes, respectively. This is the first simultaneous broad-band (i.e.,
HE+VHE) gamma-ray observation, though AGILE did not detect the source. We
combine data to derive source's spectral energy distribution and interpret its
double peaked shape within the framework of a synchrotron self compton modelComment: 5 pages, 2 figures, publishe
Dose-Dependent Immunomodulation of Human Dendritic Cells by the Probiotic Lactobacillus rhamnosus Lcr35
The response of the immune system to probiotics remains controversial. Some strains modulate the cytokine production of dendritic cells (DCs) in vitro and induce a regulatory response, while others induce conversely a pro-inflammatory response. These strain-dependent effects are thought to be linked to specific interactions between bacteria and pattern recognition receptors. We investigated the effects of a well characterized probiotic strain, Lactobacillus rhamnosus Lcr35, on human monocyte-derived immature DCs, using a wide range of bacterial concentrations (multiplicity of infection, MOI, from 0.01 to 100). DNA microarray and qRT-PCR analysis showed that the probiotic induced a large-scale change in gene expression (nearly 1,700 modulated genes, with 3-fold changes), but only with high doses (MOI, 100). The upregulated genes were mainly involved in immune response and identified a molecular signature of inflammation according to the model of Torri. Flow cytometry analysis also revealed a dose-dependent maturation of the DC membrane phenotype, until DCs reached a semi-mature state, with an upregulation of the membrane expression of CD86, CD83, HLA-DR and TLR4, associated with a down-regulation of DC-SIGN, MR and CD14. Measurement of the DC-secreted cytokines showed that Lcr35 induced a strong dose-dependent increase of the pro-Th1/Th17 cytokine levels (TNFα, IL-1β, IL-12p70, IL-12p40 and IL-23), but only a low increase in IL-10 concentration. The probiotic L. rhamnosus Lcr35 therefore induce a dose-dependent immunomodulation of human DCs leading, at high doses, to the semi-maturation of the cells and to a strong pro-inflammatory effect. These results contribute to a fuller understanding of the mechanism of action of this probiotic, and thus of its potential clinical indications in the treatment of either infectious or IgE-dependent allergic diseases
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