Analysis of index modulation in microembolic Doppler signals part I: radiation force as a new hypothesis-simulations

International audienceThe purpose of this study was to reveal the cause of frequency modulation (FM) present in microembolic Doppler ultrasound signals. This novel explanation should help the development of sensitive microembolus discrimination techniques. We suggest that the frequency modulation detected is caused by the ultrasonic radiation force (URF) acting directly on microemboli. The frequency modulation and the imposed displacement were calculated using a numerical dynamic model. By setting simulation parameters with practical values, it was possible to reproduce most microembolic frequency modulation signatures. The most interesting findings in this study were that: (1) the ultrasound radiation force acting on a gaseous microembolus and its corresponding cumulative displacement were far higher than those obtained for a solid microembolus, and that is encouraging for discrimination purposes; and 2) the calculated frequency modulation indices (FMIs) (≈20 kHz) were in good agreement with literature results. By taking into account the URF, the flow pulsatility, the beam-to-flow angle and both the velocity and the ultrasound beam profiles, it was possible to explain all erratic FM signatures of a microbubble. Finally, by measuring FMI from simulated Doppler signals and by using a constant threshold of 1 KHz, it was possible to discriminate gaseous from solid microemboli with ease

Quantification de la perfusion hépatique dans les images échographiques de contraste

Cet article présente une nouvelle technique de quantification automatique de la perfusion hépatique dans les images échographiques de contraste. Elle exploite les caractéristiques des séquences pour construire une nouvelle méthode de diffusion anisotrope robuste permettant de s'affranchir des problèmes de seuillage et d'obtenir un traitement qui s'adapte en tout point à l'information contenue dans l'image. Cette approche est ensuite couplée avec une classification floue non exclusive pour segmenter les lésions

Simulation of Frictional Contact Interactions Between Warp Yarns and Heddles Within Jacquard Harness for 3d Weaving

The relative motions between warp yarns and heddles within the Jacquard harness used for 3D weaving induce frictional interactions between these elements which may generate both damage in the yarns and weaving errors. To identify the interaction phenomena taking place within such harnesses, a finite element model, based on an implicit solution scheme [1], is proposed. In this model, all elements involved in the harness (cords, heddles, warp yarns) are represented using finite strain beam elements, and frictional contact elements are automatically created to account for frictional contact interactions. Motions defined by the Jacquard card for the shedding are prescribed as boundary conditions to the upper ends of the heddles. The resultant forces necessary to move the heddles are obtained as results of the simulation. Simulation results for an interlock fabric, with 28 warp yarns, will be presented, showing the forces evolution applied to the heddles over a few dozen consecutive sheddings

Etude de la cyclostationnarité du signal Doppler sanguin pour la détection de micro-emboles : étude préliminaire

Ce papier traite de la détection ultrasonore de micro-emboles par un système Doppler transcrânien. L'originalité de ce travail réside dans le fait que nous utilisons les propriétés cyclostationnaires du signal Doppler ultrasonore sanguin pour détecter des micro-emboles, depuis lors, masqués dans les phases de systoles-diastoles du cycle cardiaque. Dans cette étude nous évaluons théoriquement, à partir d'un modèle réaliste du signal Doppler sanguin, le spectre de corrélation. Nous proposons un paramètre informatif permettant la détection de micro-emboles et nous quantifions les performances du détecteur associé pour le comparer à un détecteur standard

Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients

<p>Abstract</p> <p>Background</p> <p>Human immunodeficiency virus (HIV) infection and antiretroviral treatment are associated with metabolic and cardiovascular complications that potentially increase the risk of atherosclerosis and cardiovascular disease in this population. Measurement of arterial wall thickness has been used as a surrogate of extent, severity and progression of atherosclerosis. A cross-sectional cohort study was performed to compare the validity of two non-invasive arterial measures: carotid intima-media thickness (IMT), a parameter of atherosclerosis, and ophthalmic artery resistance index (OARI), an index of occlusive carotid artery disease.</p> <p>Methods</p> <p>A total of 95 patients receiving highly active antiretroviral therapy (HAART) for more than 12 months were consecutively enrolled. IMT and OARI were measured by 7.5 MHz linear probe.</p> <p>Results</p> <p>There was a significant linear increase in IMT and OARI values as the grade of cardiovascular risk (0.70 and 0.69 for very low risk, 0.86 and 0.72 for low risk and 0.98 and 0.74 for medium/high risk, p < 0.001). A IMT > 0.83 and an OARI > 0.72 were the most discriminatory values for predicting a cardiovascular risk ≥ 10% (sensibility 89.6% and 75.8%; sensitivity 70.5% and 68.4%; p < 0.001).</p> <p>Conclusions</p> <p>Our data indicate that OARI may have a potential as a new precocious marker of subclinical atherosclerosis in HIV-1-infected patients.</p

The Effect of Contrast Medium SonoVue® on the Electric Charge Density of Blood Cells

The effect of contrast medium SonoVue® on the electric charge density of blood cells (erythrocytes and thrombocytes) was measured using a microelectrophoretic method. We examined the effect of adsorbed H+ and OH− ions on the surface charge of erythrocytes or thrombocytes. Surface charge density values were determined from electrophoretic mobility measurements of blood cells performed at various pH levels. The interaction between solution ions and the erythrocyte’s or thrombocyte’s surface was described by a four-component equilibrium model. The agreement between the experimental and theoretical charge variation curves of the erythrocytes and thrombocytes was good at pH 2–9. The deviation observed at a higher pH may be caused by disregarding interactions between the functional groups of blood cells

The Effect of Axial Length on the Thickness of Intraretinal Layers of the Macula.

PURPOSE: The aim of this study was to evaluate the effect of axial length (AL) on the thickness of intraretinal layers in the macula using optical coherence tomography (OCT) image analysis. METHODS: Fifty three randomly selected eyes of 53 healthy subjects were recruited for this study. The median age of the participants was 29 years (range: 6 to 67 years). AL was measured for each eye using a Lenstar LS 900 device. OCT imaging of the macula was also performed by Stratus OCT. OCTRIMA software was used to process the raw OCT scans and to determine the weighted mean thickness of 6 intraretinal layers and the total retina. Partial correlation test was performed to assess the correlation between the AL and the thickness values. RESULTS: Total retinal thickness showed moderate negative correlation with AL (r = -0.378, p = 0.0007), while no correlation was observed between the thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCC), retinal pigment epithelium (RPE) and AL. Moderate negative correlation was observed also between the thickness of the ganglion cell layer and inner plexiform layer complex (GCL+IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL) and AL which were more pronounced in the peripheral ring (r = -0.402, p = 0.004; r = -0.429, p = 0.002; r = -0.360, p = 0.01; r = -0.448, p = 0.001). CONCLUSIONS: Our results have shown that the thickness of the nuclear layers and the total retina is correlated with AL. The reason underlying this could be the lateral stretching capability of these layers; however, further research is warranted to prove this theory. Our results suggest that the effect of AL on retinal layers should be taken into account in future studies

Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging

Therapeutic microbubbles could make an important contribution to the diagnosis and treatment of cancer. Acoustic characterisation was performed on microfluidic generated microbubble populations that either were bare or had liposomes attached. Through the use of broadband attenuation techniques (3–8 MHz), the shell stiffness was measured to be 0.72 ± 0.01 and 0.78 ± 0.05 N/m and shell friction was 0.37 ± 0.05 and 0.74 ± 0.05 × 10−6 kg/s for bare and liposome-loaded microbubbles, respectively. Acoustic scatter revealed that liposome-loaded microbubbles had a lower subharmonic threshold, occurring from a peak negative pressure of 50 kPa, compared with 200 kPa for equivalent bare microbubbles. It was found that liposome loading had a negligible effect on the destruction threshold for this microbubble type, because at a mechanical index >0.4 (570 kPa), 80% of both populations were destroyed