143 research outputs found
Marcadores tumorales (p53 y Ki67) en la secuencia metaplasia, displasia, adenocarcinoma en el esĂłfago de Barrett
La Enfermedad de Reflujo Gastroesofágico (ERGE) constituye en gastroenterologĂa, junto con el sĂndrome de intestino irritable y la dispepsia, la patologĂa de más alta prevalencia. El reflujo gastroesofágico (RGE) crĂłnico y severo puede conducir a lesiones de la mucosa del esĂłfago distal, objetivables endoscĂłpicamente, como Erosiones, Estenosis, Ulceras y Metaplasia Columnar. La Metaplasia Columnar (reemplazo del epitelio esofágico por epitelio columnar) puede ser del tipo Cardial (transicional), Gástrico FĂşndico o Intestinal. La Metaplasia Intestinal (MI) se denomina EsĂłfago de Barrett, y es una condiciĂłn precancerosa con alta prevalencia (del 5 al 20%). En nuestra casuĂstica de los Ăşltimos años gira siempre alrededor del 20%. La historia natural de la Enfermedad por Reflujo Gastroesofágico es la siguiente: RGE – metaplasia cardial del epitelio esofágico – carditis por reflujo - metaplasia intestinal – displasia – adenocarcinoma. ÂżCĂłmo se podrĂa modificar esta historia natural?. A travĂ©s de la prevenciĂłn, la detecciĂłn precoz y el desarrollo de terapĂ©uticas efectivas. La lesiĂłn histolĂłgica que aparece precediendo, y/o acompañando al adenocarcinoma (ACa) , es la displasia (D), definida como una alteraciĂłn citoarquitectural de los tejidos y de las cĂ©lulas, muchas veces imprecisa y subjetiva, y que puede ser de bajo (DBG) y de alto grado (DAG). Como acercamiento al diagnĂłstico temprano del ACa, además de la bĂşsqueda de displasia, es posible detectar alteraciones moleculares o genĂ©ticas en los tejidos, mediante tĂ©cnicas inmunohistoquĂmicas, utilizando ciertos tipos de Marcadores Tumorales (MT). El objetivo principal de este trabajo es la detecciĂłn precoz (diagnĂłstico temprano del cáncer) en el esĂłfago de Barrett en nuestro medio, mediante la utilizaciĂłn de los mencionados MT.Fil: Trakal, Juan JosĂ©. Universidad CatĂłlica de CĂłrdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Sambuelli, RubĂ©n Horacio. Universidad CatĂłlica de CĂłrdoba. Facultad de Ciencias de la Salud; Argentin
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Mitigation of greenhouse gas emissions with Biochar application in compacted and uncompacted soil
Biochar may offer a substantial potential as a climate change mitigation and soil improvement agent, however little is known about its effects in fertile soils subjected to standard agricultural practices. The aim of this short–term (60 days) lab experiment, under controlled temperature and soil moisture regimes, was to investigate the interaction between soil compaction and fertiliser and biochar addition in relatively fertile Luvisol. Three different biochar types and two soil compaction levels were investigated to describe their interactive effect on soil greenhouse gas emission (GHG). A very strong effect of soil compaction on N2O emission (+280%) and an inter-action with biochar were found. The cumulative N2O emissions from the compacted soil were higher (+70–371%, depending on the biochar type) than the uncompacted soil. Soil compaction resulted in a faster onset and a faster decrease of N2O production. Biochar did not affect the temporal dynamics of N2O evolution from either soil. The addition of digestate/crop biomass biochar has resulted in a significant increase in CO2 evolution both in compacted and uncompacted soils, compared to hardwood and wood pallet biochar. In the compacted soil, NH4+ availability was positively related to N2O efflux, and CO2 emission was positively correlated to both NH4+ and SOC content. An increase in GHGs as a result of an increase in NH4+ availability was seen both in compacted and uncompacted soils, while the rates of N2O emission were modified by biochar type. Our results show a strong interaction between biochar and soil conditions and a strong effect of biochar type on GHG emissions from agricultural soils
Lead and copper-induced hormetic effect and toxicity mechanisms in lettuce (Lactuca sativa L.) grown in a contaminated soil
Lead (Pb) and copper (Cu) contamination seriously threatens agricultural production and food safety. This study aims to investigate Pb and Cu induced hormetic effect and toxicity mechanisms in lettuce (Lactuca sativa L.) and establish reliable empirical models of potentially toxic elements (PTEs) transfer in the soil–plant system. The content and distribution of Pb and Cu at subcellular levels in lettuce plants were examined using inductively coupled plasma-mass spectrometry, differential centrifugation and micro-X-ray fluorescence spectroscopy. The PTE-loaded capacity of Pb that ensures food safety was lower than that of Cu in the studied soil, but the PTE-loaded capacity of Pb that limits yield was higher than that of Cu. Lead in lettuce roots mainly accumulated in the cell wall (41%), while Cu mainly accumulated in the vacuoles (46%). The Pb and Cu were primarily distributed in the radicle of lettuce seeds under severe PTE stress, resulting in no seed development. Iron plaque formed on the root surface of lettuce seedlings and sequestered Pb and Cu via chelation. At the same concentration, lettuce was less tolerant to Cu in contaminated soil than Pb due to the higher activity of Cu ions in the soil. Lead was more phytotoxic to lettuce than Cu, however, since the radicle emerged from the seed under severe Cu levels, while it did not protrude under severe Pb levels. The potentially damaging effect of Pb in the visually healthy lettuce appeared to be higher than that of Cu under the same soil contamination level
Application for profiling access control lists
Tato práce je zaměřena na otázku zabezpeÄŤenĂ uÄŤeben pĹ™ed neoprávnÄ›nĂ˝m pouĹľĂvánĂm zdrojĹŻ sĂtÄ› v urÄŤitĂ© dobÄ›. Dále popisuje jednotlivĂ© moĹľnosti nastavenĂ smÄ›rovaÄŤe, abychom tohoto nastavenĂ dosáhli. VĂ˝sledkem práce je aplikaÄŤnà část pro ovládánĂ smÄ›rovaÄŤe pomocĂ pĹ™edpĹ™ipravenĂ˝ch pĹ™ĂstupovĂ˝ch seznamĹŻ, kterĂ© mÄ›nĂ jeho chovánĂ.This work is aimed to question of classroom security. It handle question of using sources of network in specified time. Work described ways to set a router. Result of the work of application part, which control router with predefined access lists. This lists change behaviour of router.Katedra informaÄŤnĂch technologiĂObhajoba probÄ›hla ĂşspěšnÄ› s pĹ™ĂslušnĂ˝mi demonstrativnĂmi ukázkami. PoloĹľenĂ© otázky byly zodpovÄ›zeny ke spokojenosti komise.DokonÄŤená práce s Ăşspěšnou obhajobo
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