Fast Reconstruction of Cracks Using Boundary Measurements

This paper develops a fast algorithm for locating one or more perfectly insulating, pair-wise disjoint, linear cracks in a homogeneous two-dimensional electrical conductor, using boundary measurements

The design, implementation, and assessment of software for use in the teaching of history

(1) In recent years nine arts-related departments at Glasgow University have been successful in winning funds for the creation of large databases. Although these data are being extensively exploited for research, the great potential they offer for undergraduate teaching remains largely untapped due to the lack of suitably tailored software and hardware provision. (2) Our objective is to give arts-based students access to these complex highly structured data in the classroom without requiring them to master difficult operating systems. In this way they would gain valuable transferable skills in information technology. These will enhance the historians' traditional skills of evaluating, interpreting and presenting evidence, long recognized as useful by employers. (3) The scheme will require the establishment of a centrally sited teaching laboratory comprising sixteen micro-computers and fileserver linked to the mainframe through a communications PAD. Chosen to ensure a maximum degree of compatability, the micro-computers (with the appropriate operating system) will be capable of acting as terminals, as a local area network or as single workstations. A facility technician will be employed to supervise the lab's day-to-day running, leaving a programmer/analyst to concentrate exclusively on applying and developing software for the three designated courses. (4) The software will enable students to access and scan files with ease and submit complex search, correlative, and quantitative requests by means of a friendly user interface. It will be possible to generate output in alphanumeric and graphic format either online or in hard copy. Throughout, priority will be given to transferability and portability, particularly in relation to the complementary project at the University of Edinburgh. (5) The project will be directed by Dr. R.H. Trainor consulting with a committee representing the participants - the departments of Modern History, Scottish History and Economic History, the University Archives, the Wellcome Unit for the History of Medicine - and the Computing Service. The latter will provide overall technical supervision. The department of Computing Science will co-operate in formulating an academic staff development programme. With the help of the University adviser on teaching methods the designated courses will be closely monitored in order to assess the value of the particular software, hardware and teaching methods in the project

Non-Volatile Control of Valley Polarized Emission in 2D WSe2-AlScN Heterostructures

Achieving robust and electrically controlled valley polarization in monolayer transition metal dichalcogenides (ML-TMDs) is a frontier challenge for realistic valleytronic applications. Theoretical investigations show that integration of 2D materials with ferroelectrics is a promising strategy; however, its experimental demonstration has remained elusive. Here, we fabricate ferroelectric field-effect transistors using a ML-WSe2 channel and a AlScN ferroelectric dielectric, and experimentally demonstrate efficient tuning as well as non-volatile control of valley polarization. We measured a large array of transistors and obtained a maximum valley polarization of ~27% at 80 K with stable retention up to 5400 secs. The enhancement in the valley polarization was ascribed to the efficient exciton-to-trion (X-T) conversion and its coupling with an out-of-plane electric field, viz. the quantum-confined Stark effect. This changes the valley depolarization pathway from strong exchange interactions to slow spin-flip intervalley scattering. Our research demonstrates a promising approach for achieving non-volatile control over valley polarization and suggests new design principles for practical valleytronic devices.Comment: Manuscript (22 pages and 5 figures), supporting informatio

High Density, Localized Quantum Emitters in Strained 2D Semiconductors

Two-dimensional chalcogenide semiconductors have recently emerged as a host material for quantum emitters of single photons. While several reports on defect and strain-induced single photon emission from 2D chalcogenides exist, a bottom-up, lithography-free approach to producing a high density of emitters remains elusive. Further, the physical properties of quantum emission in the case of strained 2D semiconductors are far from being understood. Here, we demonstrate a bottom-up, scalable, and lithography-free approach to creating large areas of localized emitters with high density (~150 emitters/um2) in a WSe2 monolayer. We induce strain inside the WSe2 monolayer with high spatial density by conformally placing the WSe2 monolayer over a uniform array of Pt nanoparticles with a size of 10 nm. Cryogenic, time-resolved, and gate-tunable luminescence measurements combined with near-field luminescence spectroscopy suggest the formation of localized states in strained regions that emit single photons with a high spatial density. Our approach of using a metal nanoparticle array to generate a high density of strained quantum emitters opens a new path towards scalable, tunable, and versatile quantum light sources.Comment: 45 pages, 20 figures (5 main figures, 15 supporting figures

Sex Differences in Social Interaction Behavior Following Social Defeat Stress in the Monogamous California Mouse (Peromyscus californicus)

Stressful life experiences are known to be a precipitating factor for many mental disorders. The social defeat model induces behavioral responses in rodents (e.g. reduced social interaction) that are similar to behavioral patterns associated with mood disorders. The model has contributed to the discovery of novel mechanisms regulating behavioral responses to stress, but its utility has been largely limited to males. This is disadvantageous because most mood disorders have a higher incidence in women versus men. Male and female California mice (Peromyscus californicus) aggressively defend territories, which allowed us to observe the effects of social defeat in both sexes. In two experiments, mice were exposed to three social defeat or control episodes. Mice were then behaviorally phenotyped, and indirect markers of brain activity and corticosterone responses to a novel social stimulus were assessed. Sex differences in behavioral responses to social stress were long lasting (4 wks). Social defeat reduced social interaction responses in females but not males. In females, social defeat induced an increase in the number of phosphorylated CREB positive cells in the nucleus accumbens shell after exposure to a novel social stimulus. This effect of defeat was not observed in males. The effects of defeat in females were limited to social contexts, as there were no differences in exploratory behavior in the open field or light-dark box test. These data suggest that California mice could be a useful model for studying sex differences in behavioral responses to stress, particularly in neurobiological mechanisms that are involved with the regulation of social behavior

The Mass-Metallicity Relation of a z ~ 2 Protocluster with MOSFIRE

We present Keck/MOSFIRE observations of the role of environment in the formation of galaxies at z ~ 2. Using K-band spectroscopy of Hα and [N ii] emission lines, we have analyzed the metallicities of galaxies within and around a z = 2.3 protocluster discovered in the HS1700+643 field. Our main sample consists of 23 protocluster and 20 field galaxies with estimates of stellar masses and gas-phase metallicities based on the N2 strong-line metallicity indicator. With these data we have examined the mass–metallicity relation with respect to environment at z ~ 2. We find that field galaxies follow the well-established trend between stellar mass and metallicity, such that more massive galaxies have larger metallicities. The protocluster galaxies, however, do not exhibit a dependence of metallicity on mass, with the low-mass protocluster galaxies showing an enhancement in metallicity compared to field galaxies spanning the same mass range. A comparison with galaxy formation models suggests that the mass-dependent environmental trend we observed can be qualitatively explained in the context of the recycling of "momentum-driven" galaxy wind material. Accordingly, winds are recycled on a shorter timescale in denser environments, leading to an enhancement in metallicity at fixed mass for all but the most massive galaxies. Future hydrodynamical simulations of z ~ 2 overdensities matching the one in the HS1700 field will be crucial for understanding the origin of the observed environmental trend in detail

The Lyα Properties of Faint Galaxies at z ~ 2-3 with Systemic Redshifts and Velocity Dispersions from Keck-MOSFIRE

We study the Lyα profiles of 36 spectroscopically detected Lyα-emitters (LAEs) at z ~ 2-3, using Keck MOSFIRE to measure systemic redshifts and velocity dispersions from rest-frame optical nebular emission lines. The sample has a median optical magnitude R = 26.0, and ranges from R ≃ 23 to R > 27, corresponding to rest-frame UV absolute magnitudes M _(UV) ≃ –22 to M ^(UV) > –18.2. Dynamical masses range from M_(dyn) 3σ significance: brighter galaxies with larger velocity dispersions tend to have larger values of Δv Lyα. We also make use of a comparison sample of 122 UV-color-selected R < 25.5 galaxies at z ~ 2, all with Lyα emission and systemic redshifts measured from nebular emission lines. Using the combined LAE and comparison samples for a total of 158 individual galaxies, we find that Δv_(Lyα) is anti-correlated with the Lyα equivalent width with 7σ significance. Our results are consistent with a scenario in which the Lyα profile is determined primarily by the properties of the gas near the systemic redshift; in such a scenario, the opacity to Lyα photons in lower mass galaxies may be reduced if large gaseous disks have not yet developed and if the gas is ionized by the harder spectrum of young, low metallicity stars

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Background Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects. Methods FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762. Findings Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839–1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26–6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38–2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months. Interpretation Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function. Funding UK Stroke Association and NIHR Health Technology Assessment Programme