El yacimiento arqueológico de El Saucedo (Talavera La Nueva, Toledo): balance y perspectivas

En este artículo presentamos una síntesis de los trabajos de investigación, conservación y difusión reali-zados en el yacimiento de b'l Saucedo hasta el presente, así como un esbozo de los planes de actuación para el futuro

Service-learning by PhD students to aid socially neglected people

In recent years, there have been calls for change in higher education to meet the needs of today's society. A higher education that enables our students to offer solutions to struggling areas of our society. Innovative and differentiating solutions from what we have been used to until now. In view of these needs, it is necessary to unite the society, which reveals its main needs, and the university community, which offers solutions on the knowledge acquired. One of the ways to carry out this integration is based on developing a methodology called "Service-Learning" (SL). This learning method is based on a strategy of collaboration between educational centers and society itself. At present, this methodology is spreading within higher education institutions worldwide. This learning strategy emerged as a learning methodology in America, to be later extended to Europe, from the United Kingdom to the rest of the continent, and from there, reaching a global impact. Throughout this long road, this methodology has been improving, encouraging the creation of increasingly strong links between educational institutions and universities, and society, by promoting the improvement of student training as well as the development of certain areas of society. This paper presents a SL project where two apparently disparate areas are related, such as doctoral students in the area of chemical engineering and sectors of society at risk of exclusion. Specifically, the objective is for the students to present some of the technological developments they have achieved to a neglected sector of society, which should participate not only in the developments, but also learning about the technical base of such technologies.This work has been carried out with the financial support of the SL UCM 2018/19_16 project and the Madrid City Council.Torrecilla, J.; Buitrón Ruiz, S.; Sánchez, M.; Cancilla, JC.; Pradana López, S.; Perez Calabuig, AM. (2020). Service-learning by PhD students to aid socially neglected people. En 6th International Conference on Higher Education Advances (HEAd'20). Editorial Universitat Politècnica de València. (30-05-2020):831-837. https://doi.org/10.4995/HEAd20.2020.11153OCS83183730-05-202

Phosphorylation and regulation of a G protein–coupled receptor by protein kinase CK2

We demonstrate a role for protein kinase casein kinase 2 (CK2) in the phosphorylation and regulation of the M3-muscarinic receptor in transfected cells and cerebellar granule neurons. On agonist occupation, specific subsets of receptor phosphoacceptor sites (which include the SASSDEED motif in the third intracellular loop) are phosphorylated by CK2. Receptor phosphorylation mediated by CK2 specifically regulates receptor coupling to the Jun-kinase pathway. Importantly, other phosphorylation-dependent receptor processes are regulated by kinases distinct from CK2. We conclude that G protein–coupled receptors (GPCRs) can be phosphorylated in an agonist-dependent fashion by protein kinases from a diverse range of kinase families, not just the GPCR kinases, and that receptor phosphorylation by a defined kinase determines a specific signalling outcome. Furthermore, we demonstrate that the M3-muscarinic receptor can be differentially phosphorylated in different cell types, indicating that phosphorylation is a flexible regulatory process where the sites that are phosphorylated, and hence the signalling outcome, are dependent on the cell type in which the receptor is expressed

Fossil Groups Origins III. Characterization of the sample and observational properties of fossil systems

(Abridged) Fossil systems are group- or cluster-sized objects whose luminosity is dominated by a very massive central galaxy. In the current cold dark matter scenario, these objects formed hierarchically at an early epoch of the Universe and then slowly evolved until present day. That is the reason why they are called {\it fossils}. We started an extensive observational program to characterize a sample of 34 fossil group candidates spanning a broad range of physical properties. Deep $r-$band images were taken for each candidate and optical spectroscopic observations were obtained for $\sim$ 1200 galaxies. This new dataset was completed with SDSS DR7 archival data to obtain robust cluster membership and global properties of each fossil group candidate. For each system, we recomputed the magnitude gaps between the two brightest galaxies ($\Delta m_{12}$) and the first and fourth ranked galaxies ($\Delta m_{14}$) within 0.5 $R_{{\rm 200}}$. We consider fossil systems those with $\Delta m_{12} \ge 2$ mag or $\Delta m_{14} \ge 2.5$ mag within the errors. We find that 15 candidates turned out to be fossil systems. Their observational properties agree with those of non-fossil systems. Both follow the same correlations, but fossils are always extreme cases. In particular, they host the brightest central galaxies and the fraction of total galaxy light enclosed in the central galaxy is larger in fossil than in non-fossil systems. Finally, we confirm the existence of genuine fossil clusters. Combining our results with others in the literature, we favor the merging scenario in which fossil systems formed due to mergers of $L^\ast$ galaxies. The large magnitude gap is a consequence of the extreme merger ratio within fossil systems and therefore it is an evolutionary effect. Moreover, we suggest that at least one candidate in our sample could represent a transitional fossil stage.Comment: 14 pages, 11 figures, accepted for publication in A&

The space density distribution of galaxies in the absolute magnitude - rotation velocity plane: a volume-complete Tully-Fisher relation from CALIFA stellar kinematics

The space density distribution of galaxies in the absolute magnitude - rotation velocity plane: a volume-complete Tully-Fisher relation from CALIFA stellar kinematicsComment: Accepted to A&

Diferencias de género en perfiles de objetivos de vida de estudiantes universitarios y su relación con bienestar psicológico

Diversos estudios evidencian que el bienestar psicológico está ampliamente relacionado con los planes personales, concluyendo que el cumplimiento o no de los objetivos planteados resultará ser uno de los mejores predictores del bienestar. La presente investigación tiene por objetivo profundizar en el estudio de la relación que existe entre los Objetivos de Vida (OV) y el Bienestar Psicológico (BP) en estudiantes universitarios pertenecientes a la Facultad de Psicología. Se enfatizarán las diferencias de género en relación a la descripción de los objetivos personales

N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.

Changes in synaptic strength mediated by ionotropic glutamate N-methyl-D-asparate (NMDA) receptors is generally considered to be the molecular mechanism underlying memory and learning. NMDA receptors themselves are subject to regulation through signaling pathways that are activated by G-protein-coupled receptors (GPCRs). In this study we investigate the ability of NMDA receptors to regulate the signaling of GPCRs by focusing on the G(q/11)-coupled M(3)-muscarinic receptor expressed endogenously in mouse cerebellar granule neurons. We show that NMDA receptor activation results in the phosphorylation and desensitization of M(3)-muscarinic receptors through a mechanism dependent on NMDA-mediated calcium influx and the activity of calcium-calmodulin-dependent protein kinase II. Our study reveals a complex pattern of regulation where GPCRs (M(3)-muscarinic) and NMDA receptors can feedback on each other in a process that is likely to influence the threshold value of signaling networks involved in synaptic plasticity

Anxiety, depression and stress in nurses working in intensive therapy units with COVID-19 patients, Mendoza, 2021

En contextos de pandemia, los trabajadores de la salud son especialmente vulnerables a los problemas de salud mental y a patologías graves. Los objetivos de este estudio fueron explorar y describir los niveles de ansiedad y depresión en el personal de enfermería que atiende pacientes con COVID-19 en unidades de terapia intensiva, y describir los indicadores de estrés en relación con su actividad laboral. MÉTODO: Estudio descriptivo y transversal. Muestra intencional de 52 enfermeros y enfermeras que trabajan en unidades de terapia intensiva para pacientes con COVID-19 en la Ciudad de Mendoza. Se aplicaron cuestionarios validados para evaluar la ansiedad, la depresión y el estrés percibido. RESULTADOS: Se observaron niveles elevados de ansiedad en el 72,1% de la muestra, y depresión en el 13,5%. Los indicadores más elevados de estrés fueron: sentirse desanimado y cansado (80,8%), agotado mentalmente (76,9%), no sentir energía (73,1%) y sentir muchas preocupaciones (75%). Los indicadores favorables fueron: 76,9% no se siente obligado a hacer sus tareas; y 55,8% siente que realmente disfruta de su quehacer. DISCUSIÓN: Se observaron niveles elevados de ansiedad y depresión, y se identificaron indicadores de estrés relacionados con la tensión, el agotamiento físico-emocional y la sobrecarga laboral; se encontraron indicadores relacionados a factores protectores dentro del ámbito laboral. Se analizan los datos preliminares sobre el malestar emocional del personal de enfermería en el contexto de la pandemia por COVID-19.In pandemic contexts, health workers are especially vulnerable to mental health problems and risky pathologies. Objectives of the study: 1) to explore and describe levels of anxiety and depression in intensive care unit nurses who work with COVID-19 patients and 2) to describe indicators of stress in relation to their work activity. METHOD: Descriptive, cross-sectional study. Intentional sample of 52 nurses, of both sexes, who work in intensive care units COVID-19, Mendoza. Validated questionnaires were applied to assess anxiety, depression and perceived stress. RESULTS: high levels of anxiety in 72.1% of the sample and 13.5% of depression; Higher indicators of stress: feeling discouraged and tired (80.8%), mentally exhausted (76.9%), not feeling energy (73.1%), feeling very worried (75%); as favorable indicators: 76.9% do not feel that they do things out of obligation, 55.8% feel that they are doing things that they really like. DISCUSSION: High levels of anxiety and depression were observed and indicators of stress related to tension and physical-emotional exhaustion and work overload were identified; Indicators related to protective factors were found within the workplace. Preliminary data is discussed on the emotional distress of male and female nurses in times of pandemic by COVID-19.Fil: Torrecilla, Norma Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Janet, Victoria M.. Universidad del Aconcagua. Facultad de Psicología; ArgentinaFil: Richaud de Minzi, C.. Universidad Austral; Argentin

Observational hints of radial migration in disc galaxies from CALIFA

Context. According to numerical simulations, stars are not always kept at their birth galactocentric distances but they have a tendency to migrate. The importance of this radial migration in shaping galactic light distributions is still unclear. However, if radial migration is indeed important, galaxies with different surface brightness (SB) profiles must display differences in their stellar population properties. Aims: We investigate the role of radial migration in the light distribution and radial stellar content by comparing the inner colour, age, and metallicity gradients for galaxies with different SB profiles. We define these inner parts, avoiding the bulge and bar regions and up to around three disc scale lengths (type I, pure exponential) or the break radius (type II, downbending; type III, upbending). Methods: We analysed 214 spiral galaxies from the CALIFA survey covering different SB profiles. We made use of GASP2D and SDSS data to characterise the light distribution and obtain colour profiles of these spiral galaxies. The stellar age and metallicity profiles were computed using a methodology based on full-spectrum fitting techniques (pPXF, GANDALF, and STECKMAP) to the Integral Field Spectroscopic CALIFA data. Results: The distributions of the colour, stellar age, and stellar metallicity gradients in the inner parts for galaxies displaying different SB profiles are unalike as suggested by Kolmogorov-Smirnov and Anderson-Darling tests. We find a trend in which type II galaxies show the steepest profiles of all, type III show the shallowest, and type I display an intermediate behaviour. Conclusions: These results are consistent with a scenario in which radial migration is more efficient for type III galaxies than for type I systems, where type II galaxies present the lowest radial migration efficiency. In such a scenario, radial migration mixes the stellar content, thereby flattening the radial stellar properties and shaping different SB profiles. However, in light of these results we cannot further quantify the importance of radial migration in shaping spiral galaxies, and other processes, such as recent star formation or satellite accretion, might play a role