Digital Music Sampling and Copyright Law

Copyright law governing digital music sampling is faced with two competing interests: first, the owners of recording and composition copyrights need to be reasonably compensated when their creative works are reused by sampling artists, but secondly, sampling artists should have a reasonable degree of freedom to rework fragments of existing recordings at a reasonable cost. A system needs to balance these interests and reduce the degree of uncertainty that arises when the use of a sample infringes a copyright. This Article will discuss the current state of the law as it relates to digital sampling and will then articulate five goals that should be taken into account by any proposed solution to the sampling problem. It will also discuss the various proposals, evaluating each of their strengths and weaknesses with respect to the five goals. Ultimately, it will conclude that compulsory license schemes are best suited to solving, or at least minimizing, the problem

HispaVeg: a new online vegetation plot database for Spain

We describe a new online database, named HispaVeg, which currently holds data from 2663 vegetation plots of Spanish woodlands, scrublands and grasslands. Unlike other similar databases, a detailed description of the structure is stored with the floristic data of each plot (i.e., number and physiognomy of the vertical layers, cover values for each layer).Most of the vegetation plots are large rectangles (400 to 2000 square meters) with an average of 34 species per plot. The survey dates range from 1956 to present, with most of the records between 1964 and 1994. The elevation of the plots ranges from 0 to 2880, with most of the plots between 300 and 1500 m. HispaVeg is freely available to the scientific community. Users can query the online database, view printable reports for each plot and download spreadsheet-like raw data for subsets of vegetation plots

Active methodologies and teaching performance: a necessary relationship in the field of education

[EN] In the present communication, we present the project developed within the Teaching Innovation Group (APAC) of the Faculty of Education at the University of Burgos: “Active Methodologies and Teacher Performance: a road towards inclusion in the classroom”. The principal objective of this project is to contribute empirical evidence on the impact that the use of active methodologies has on teaching performance in the classroom. Its results are the basis for the transformation of initial teacher training, because Universities are responsible for training the teachers who will be at the forefront of schools in the 21st c. They have therefore to be offered access to the resources in their initial and lifelong education that permit change, allowing them to construct the paradigm of inclusive, sustainable, and quality education.[ES] En la presente comunicación, presentamos el proyecto desarrollado dentro del Grupo de Innovación Docente (APAC) de la Facultad de Educación de la Universidad de Burgos: "Metodologías Activas y Desempeño Docente: un camino hacia la inclusión en el aula". El objetivo principal de este proyecto es aportar evidencia empírica sobre el impacto que tiene el uso de metodologías activas en el rendimiento docente en el aula. Sus resultados son la base para la transformación de la formación inicial del profesorado, porque las universidades son responsables de la formación de los profesores que estarán a la vanguardia de las escuelas en el 21 stdo. Por lo tanto, se les debe ofrecer acceso a los recursos en su educación inicial y de por vida que permitan el cambio, permitiéndoles construir el paradigma de la educación inclusiva, sostenible y de calidad.http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Luis, MI.; De La Torre Cruz, T.; Huelmo, J.; Llamazares, MC.; Ruiz, E.; Prieto, C.; Palmero, C.... (2018). Active methodologies and teaching performance: a necessary relationship in the field of education. Editorial Universitat Politècnica de València. 995-1001. https://doi.org/10.4995/HEAD18.2018.8134OCS995100

La situación en otros países amazónicos: Perú y Colombia

[ES]Seminario internacional “Reflexiones políticas y jurídicas sobre la protección del medio ambiente y las políticas de desarrollo en la Amazonia”, organizado por el Centro de Estudios Brasileños de la Universidad de Salamanca. Vídeo de la mesa de debate “La situación en otros países amazónicos: Perú y Colombia”, celebrada el 4 de mayo de 2021, conformada por la Prof.ª Myriam Ruiz (Tecnológico de Antioquia, Medellín, Colombia); el Prof. Dino Carlos Coria (Universidad de Lima, Perú), moderada por la Prof.ª Nieves Sanz Mulas (Universidad de Salamanca, USAL, España). [PO]Seminário internacional “Reflexões políticas e jurídicas sobre a proteção do meio ambiente e as políticas de desenvolvimento na Amazônia”, organizado pelo Centro de Estudos Brasileiros da Universidade de Salamanca. Vídeo da mesa de debate “A situação em outros países amazônicos: Peru e Colômbia”, celebrada em 4 de maio de 2021, formada pela Prof.ª Myriam Ruiz (Tecnológico de Antioquia, Medellín, Colômbia); o Prof. Dino Carlos Coria (Universidade de Lima, Peru), moderada pela Prof.ª Nieves Sanz Mulas (Universidade de Salamanca, USAL, Espanha)

Joint Effect of MCP-1 Genotype GG and MMP-1 Genotype 2G/2G Increases the Likelihood of Developing Pulmonary Tuberculosis in BCG-Vaccinated Individuals

We previously reported that the – 2518 MCP-1 genotype GG increases the likelihood of developing tuberculosis (TB) in non-BCG-vaccinated Mexicans and Koreans. Here, we tested the hypothesis that this genotype, alone or together with the – 1607 MMP-1 functional polymorphism, increases the likelihood of developing TB in BCG-vaccinated individuals. We conducted population-based case-control studies of BCG-vaccinated individuals in Mexico and Peru that included 193 TB cases and 243 healthy tuberculin-positive controls from Mexico and 701 TB cases and 796 controls from Peru. We also performed immunohistochemistry (IHC) analysis of lymph nodes from carriers of relevant two-locus genotypes and in vitro studies to determine how these variants may operate to increase the risk of developing active disease. We report that a joint effect between the – 2518 MCP-1 genotype GG and the – 1607 MMP-1 genotype 2G/2G consistently increases the odds of developing TB 3.59-fold in Mexicans and 3.9-fold in Peruvians. IHC analysis of lymph nodes indicated that carriers of the two-locus genotype MCP-1 GG MMP-1 2G/2G express the highest levels of both MCP-1 and MMP-1. Carriers of these susceptibility genotypes might be at increased risk of developing TB because they produce high levels of MCP-1, which enhances the induction of MMP-1 production by M. tuberculosis-sonicate antigens to higher levels than in carriers of the other two-locus MCP-1 MMP-1 genotypes studied. This notion was supported by in vitro experiments and luciferase based promoter activity assay. MMP-1 may destabilize granuloma formation and promote tissue damage and disease progression early in the infection. Our findings may foster the development of new and personalized therapeutic approaches targeting MCP-1 and/or MMP-1

Cómo se compra en Valladolid

Producción CientíficaEstudio de los hábitos de consumo en el comercio minorista de la ciudad de ValladolidGeografíaInforme encargado por AVADECO con la colaboración de la Consejería de Industria, Comercio y Turismo de la Junta de Castilla y Leó

Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy

Aberrant endocannabinoid signaling accompanies several neurodegenerative disorders, including multiple sclerosis. Here, we report altered endocannabinoid signaling in X-linked adrenoleukodystrophy (X-ALD), a rare neurometabolic demyelinating syndrome caused by malfunction of the peroxisomal ABCD1 transporter, resulting in the accumulation of very long-chain fatty acids (VLCFAs). We found abnormal levels of cannabinoid receptor 2 (CB2r) and related endocannabinoid enzymes in the brain and peripheral blood mononuclear cells (PBMCs) of X-ALD patients and in the spinal cord of a murine model of X-ALD. Preclinical treatment with a selective agonist of CB2r (JWH133) halted axonal degeneration and associated locomotor deficits, along with normalization of microgliosis. Moreover, the drug improved the main metabolic disturbances underlying this model, particularly in redox and lipid homeostatic pathways, including increased lipid droplets in motor neurons, through the modulation of the GSK-3β/NRF2 axis. JWH133 inhibited Reactive Oxygen Species elicited by excess VLCFAs in primary microglial cultures of Abcd1-null mice. Furthermore, we uncovered intertwined redox and CB2r signaling in the murine spinal cords and in patient PBMC samples obtained from a phase II clinical trial with antioxidants (NCT01495260). These findings highlight CB2r signaling as a potential therapeutic target for X-ALD and perhaps other neurodegenerative disorders that present with dysregulated redox and lipid homeostasis.This study was funded by the Institute of Health Carlos III through projects [PI19/01008] to SF and [PI20/00759] to AP (co-funded by the European Regional Development Fund, ERDF, a way to build Europe), Miguel Servet program [CPII16/00016] to SF and [PFIS, FI18/00141] to LPS (co-funded by the European Social Fund, ESF investing in your future). This study was also funded by grants from the Spanish Ministry of Health, Social Services and Equality (EC10-137), the Autonomous Government of Catalonia [2017SGR1206], the Hesperia Foundation, CERTIS Obres i Serveis, and the Crowd funding Campaign Arnau’97 to AP. JP was a predoctoral fellow of IDIBELL. The Center for Biomedical Research on Rare Diseases (CIBERER), an initiative of the Institute of Health Carlos III, funded the position of MR. Locomotor experiments were performed by the SEFALer unit F5 led by AP, which belongs to the CIBERER structure. We thank the CERCA Program/Generalitat de Catalunya for institutional support

Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity

Sphingolipids function as membrane constituents and signaling molecules, with crucial roles in human diseases, from neurodevelopmental disorders to cancer, best exemplified in the inborn errors of sphingolipid metabolism in lysosomes. The dihydroceramide desaturase Delta 4-dihydroceramide desaturase 1 (DEGS1) acts in the last step of a sector of the sphingolipid pathway, de novo ceramide biosynthesis. Defects in DEGS1 cause the recently described hypomyelinating leukodystrophy-18 (HLD18) (OMIM #618404). Here, we reveal that DEGS1 is a mitochondria-associated endoplasmic reticulum membrane-resident (MAM-resident) enzyme, refining previous reports locating DEGS1 at the endoplasmic reticulum only. Using patient fibroblasts, multiomics, and enzymatic assays, we show that DEGS1 deficiency disrupts the main core functions of the MAM: (a) mitochondrial dynamics, with a hyperfused mitochondrial network associated with decreased activation of dynamin-related protein 1; (b) cholesterol metabolism, with impaired sterol O-acyltransferase activity and decreased cholesteryl esters; (c) phospholipid metabolism, with increased phosphatidic acid and phosphatidylserine and decreased phosphatidylethanolamine; and (d) biogenesis of lipid droplets, with increased size and numbers. Moreover, we detected increased mitochondrial superoxide species production in fibroblasts and mitochondrial respiration impairment in patient muscle biopsy tissues. Our findings shed light on the pathophysiology of HLD18 and broaden our understanding of the role of sphingolipid metabolism in MAM function

Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis

Background: Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to determine the prevalence of S. tigurinus among VGS endocarditis in Spain, and to compare the clinical characteristics and outcomes of endocarditis caused by S. tigurinus and other VGS. Methods: Retrospective nationwide study, performed between 2008 and 2016 in 9 Spanish hospitals from 7 different provinces comprising 237 cases of infective endocarditis. Streptococcal isolates were identified by sequencing fragments of their 16S rRNA, sodA and groEL genes. Clinical data of patients with streptococcal endocarditis were prospectively collected according to a pre-established protocol. Results: Patients with endocarditis represented 7/9 (77.8%) and 26/86 (30.2%) of the bacteraemias caused by S. tigurinus and other VGS, respectively (p < 0.001), in two of the hospital participants. Among patients with streptococcal endocarditis, 12 different Streptococcus species were recognized being S. oralis, S. tigurinus and S. mitis the three more common. No relevant statistical differences were observed in the clinical characteristics and outcomes of endocarditis caused by the different VGS species. Conclusions: In this multicenter study performed in Spain, S. tigurinus showed a higher predilection for the endocardial endothelium as compared to other VGS. However, clinical characteristics and outcomes of endocarditis caused by S. tigurinus did not significantly differ from endocarditis caused by other oral streptococci.JMM received a personal 80:20 research grant from the Institut d’InvestigacionsBiomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain during 2017–19. Nofunding entity played any role in the design of the study and data collection,analysis, and interpretation of data and in writing the manuscript