Let’s Talk – Interoperability between University CRIS/IR and Researchfish : a case study from the UK

Research funders and research organisations both require feedback on the progress, productivity and quality of the research they support. This information originates with researchers, but may be captured in a variety of systems including University CRIS/IR and funder systems. In 2014 all 7 national Research Councils (collectively referred to as RCUK) implemented a harmonised approach to the collection of research output data, currently supported by Researchfish Ltd (referred to as the Researchfish® system). In 2016 this process is gathering feedback from over 60,000 researchers in all UK Universities, and for funders in the USA, Canada, Denmark and the Netherlands, tracking more than £40billion of public and charity research investment and is adding to a dataset of more than 1.5 million outputs. Researchers, research managers and funders want to find ways to capture this data once and achieve wide re-use of the information. Working together University and Research Council officers, Researchfish Ltd. and Jisc have highlighted that it is important for the “interoperability” between research information systems to be improved. These organisations have started a programme of work to improve the bi-directional flow of information between University and funder systems

A regional nuclear conflict would compromise global food security

A limited nuclear war between India and Pakistan could ignite fires large enough to emit more than 5 Tg of soot into the stratosphere. Climate model simulations have shown severe resulting climate perturbations with declines in global mean temperature by 1.8 °C and precipitation by 8%, for at least 5 y. Here we evaluate impacts for the global food system. Six harmonized state-of-the-art crop models show that global caloric production from maize, wheat, rice, and soybean falls by 13 (±1)%, 11 (±8)%, 3 (±5)%, and 17 (±2)% over 5 y. Total single-year losses of 12 (±4)% quadruple the largest observed historical anomaly and exceed impacts caused by historic droughts and volcanic eruptions. Colder temperatures drive losses more than changes in precipitation and solar radiation, leading to strongest impacts in temperate regions poleward of 30°N, including the United States, Europe, and China for 10 to 15 y. Integrated food trade network analyses show that domestic reserves and global trade can largely buffer the production anomaly in the first year. Persistent multiyear losses, however, would constrain domestic food availability and propagate to the Global South, especially to food-insecure countries. By year 5, maize and wheat availability would decrease by 13% globally and by more than 20% in 71 countries with a cumulative population of 1.3 billion people. In view of increasing instability in South Asia, this study shows that a regional conflict using <1% of the worldwide nuclear arsenal could have adverse consequences for global food security unmatched in modern history

A Regional Nuclear Conflict Would Compromise Global Food Security

A limited nuclear war between India and Pakistan could ignite fires large enough to emit more than 5 Tg of soot into the stratosphere. Climate model simulations have shown severe resulting climate perturbations with declines in global mean temperature by 1.8 C and precipitation by 8%, for at least 5 y. Here we evaluate impacts for the global food system. Six harmonized state-of-the-art crop models show that global caloric production from maize, wheat, rice, and soybean falls by 13 (1)%, 11 (8)%, 3 (5)%, and 17 (2)% over 5 y. Total single-year losses of 12 (4)% quadruple the largest observed historical anomaly and exceed impacts caused by historic droughts and volcanic eruptions. Colder temperatures drive losses more than changes in precipitation and solar radiation, leading to strongest impacts in temperate regions poleward of 30N, including the United States, Europe, and China for 10 to 15 y. Integrated food trade network analyses show that domestic reserves and global trade can largely buffer the production anomaly in the first year. Persistent multiyear losses, however, would constrain domestic food availability and propagate to the Global South, especially to food-insecure countries. By year 5, maize and wheat availability would decrease by 13% globally and by more than 20% in 71 countries with a cumulative population of 1.3 billion people. In view of increasing instability in South Asia, this study shows that a regional conflict using <1% of the worldwide nuclear arsenal could have adverse consequences for global food security unmatched in modern history

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

A Vandal Proof Telephone Kiosk

A recent competition, 'The GEC Schools Design Prize', organised by the DesignCouncil and sponsored by GEC, made its presentation of prizes on November 17th, in this the first year of what is to become an annual event. In this competition our school was fortunate enough to be selected as one of the prizewinners, within the junior section (13-16 years), for a project undertaken by a team of six (four boys and two girls). The competition did not specify or suggest any particular subject, leaving any such decision to the schools themselves. The organisers did stipulate, however, that the project should be aimed at designing a functional three-dimensional product capable of being manufactured