Project management e amministrazione digitale. Criteri di gestione e misurazione di progetti e archivi digitali

Every organization and every innovation, including digital transformation, are based on projects; one third of the world’s economy is based on projects. Digital-based innovations consist of “multidisciplinary” prospects based on juridical, organizational, archival and technological dimensions. Moreover the project has to use management methodologies: project management has become an important discipline in this context. The project and its management methodologies use a systemic approach for the management areas. Similarly digital archive innovations require a multidisciplinary approach: it identifies a transformation from the pure analytical approach towards a complex, multidisciplinary and interdependent systems. The project and digital archive initiatives have to strategically use the approach and project oriented organization, based on a multidisciplinary and systemic approach: the “digital project”. This approach requires to measure results of the used digital strategies and to evaluate the relative projects. The strategic perspectives management consists of balanced indicators for the related disciplines, through using Digital Scorecard (DSC), digital archive performance named Overall digital Archive Effectiveness (OAE) and the Digital Manager based on an equilibrium of competences emerging from the application of games theory

Design of the EnVisS instrument optical head

The EnVisS (Entire Visible Sky) instrument is one of the payloads of the European Space Agency Comet Interceptor mission. The aim of the mission is the study of a dynamically new comet, i.e. a comet that never travelled through the solar system, or an interstellar object, entering the inner solar system. As the mission three-spacecraft system passes through the comet coma, the EnVisS instrument maps the sky, as viewed from the interior of the comet tail, providing information on the dust properties and distribution. EnVisS is mounted on a spinning spacecraft and the full sky (i.e. 360°x180°) is entirely mapped thanks to a very wide field of view (180°x45°) optical design selected for the EnVisS camera. The paper presents the design of the EnVisS optical head. A fisheye optical layout has been selected because of the required wide field of view (180°x45°). This kind of layout has recently found several applications in Earth remote sensing (3MI instrument on MetOp SG) and in space exploration (SMEI instrument on Coriolis, MARCI on Mars reconnaissance orbiter). The EnVisS optical head provides a high resolved image to be coupled with a COTS detector featuring 2kx2k pixels with pitch 5.5µm. Chromatic aberration is corrected in the waveband 550-800nm, while the distortion has been controlled over the whole field of view to remain below 8% with respect to an Fθ mapping law. Since the camera will be switched on 24 hours before the comet closest encounter, the operative temperature will change during the approaching phase and crossing of the comet’s coma. In the paper, we discuss the solution adopted for reaching these challenging performances for a space-grade design, while at the same time respecting the demanding small allocated volume and mass for the optical and mechanical design. The view expressed herein can in no way be taken to reflect the official opinion of the European Space Agency

The pre-launch characterization of SIMBIO-SYS/VIHI imaging spectrometer for the BepiColombo mission to Mercury. I. Linearity, radiometry, and geometry calibrations

Before integration aboard European Space Agency BepiColombo mission to Mercury, the visible and near infrared hyperspectral imager underwent an intensive calibration campaign. We report in Paper I about the radiometric and linearity responses of the instrument including the optical setups used to perform them. Paper II [F. Altieri et al., Rev. Sci. Instrum. 88, 094503 (2017)] will describe complementary spectral response calibration. The responsivity is used to calculate the expected instrumental signal-to-noise ratio for typical observation scenarios of the BepiColombo mission around Mercury. A description is provided of the internal calibration unit that will be used to verify the relative response during the instrument's lifetime. The instrumental spatial response functions as measured along and across the spectrometer's slit direction were determined by means of spatial scans performed with illuminated test slits placed at the focus of a collimator. The dedicated optical setup used for these measurements is described together with the methods used to derive the instrumental spatial responses at different positions within the 3 . 5 ° field of view and at different wavelengths in the 0.4-2.0 μm spectral range. Finally, instrument imaging capabilities and Modulated Transfer Function are tested by using a standard mask as a target

LUMIO: achieving autonomous operations for Lunar exploration with a CubeSat

The Lunar Meteoroid Impacts Observer (LUMIO) is one of the four projects selected within ESA’s SysNova competition to develop a small satellite for scientific and technology demonstration purposes to be deployed by a mother ship around the Moon. The mission utilizes a 12U form-factor CubeSat which carries the LUMIO-Cam, an optical instrument capable of detecting light flashes in the visible spectrum to continuously monitor and process the meteoroids impacts. In this paper, we will describe the mission concept and focus on the performance of a novel navigation concept using Moon images taken as byproduct of the LUMIO-Cam operations. This new approach will considerably limit the operations burden on ground, aiming at autonomous orbit-attitude navigation and control. Furthermore, an efficient and autonomous strategy for collection, processing, categorization, and storage of payload data is also described to cope with the limited contact time and downlink bandwidth. Since all communications have to go via a Lunar Orbiter (mothership), all commands and telemetry/data will have to be forwarded to/from the mother ship. This will prevent quasi-real time operations and will be the first time for CubeSats as they have never flown so far from Earth

SIMBIO-SYS Near Earth Commissioning Phase: a step forward toward Mercury

On December 2018, the Near Earth Commissioning Phase (NECP) has been place forSIMBIO-SYS (Spectrometers and Imagers for MPO BepiColombo Integrated Observatory - SYStem), the suite part of the scientific payload of the BepiColombo ESA-JAXA mission. SIMBIO-SYS is composed of three channels: the high resolution camera (HRIC), the stereo camera (STC) and the Vis/NIR spectrometer (VIHI) . During the NECP the three channels have been operated properly. For the three channels were checked the operativity and the performance. The commanded operations allowed to verify all the instrument functionalities demonstrating that all SIMBIO-SYS channels and subsystems work nominally. During this phase we also validated the Ground Segment Equipment (GSE) and the data analysis tools developed by the team

An explainable model of host genetic interactions linked to COVID-19 severity

We employed a multifaceted computational strategy to identify the genetic factors contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing (WES) dataset of a cohort of 2000 Italian patients. We coupled a stratified k-fold screening, to rank variants more associated with severity, with the training of multiple supervised classifiers, to predict severity based on screened features. Feature importance analysis from tree-based models allowed us to identify 16 variants with the highest support which, together with age and gender covariates, were found to be most predictive of COVID-19 severity. When tested on a follow-up cohort, our ensemble of models predicted severity with high accuracy (ACC = 81.88%; AUCROC = 96%; MCC = 61.55%). Our model recapitulated a vast literature of emerging molecular mechanisms and genetic factors linked to COVID-19 response and extends previous landmark Genome-Wide Association Studies (GWAS). It revealed a network of interplaying genetic signatures converging on established immune system and inflammatory processes linked to viral infection response. It also identified additional processes cross-talking with immune pathways, such as GPCR signaling, which might offer additional opportunities for therapeutic intervention and patient stratification. Publicly available PheWAS datasets revealed that several variants were significantly associated with phenotypic traits such as "Respiratory or thoracic disease", supporting their link with COVID-19 severity outcome.A multifaceted computational strategy identifies 16 genetic variants contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing dataset of a cohort of Italian patients

Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19

Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections. Carriers are reported to be asymptomatic. Exome analysis of about 3000 SARS-CoV-2 infected subjects of different severities, belonging to the GEN-COVID cohort, revealed the specific role of vWF cleaving enzyme ADAMTS13 (A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13). We report here that ultra-rare variants in a heterozygous state lead to a rare form of COVID-19 characterized by hyper-inflammation signs, which segregates in families as an autosomal dominant disorder conditioned by SARS-CoV-2 infection, sex, and age. This has clinical relevance due to the availability of drugs such as Caplacizumab, which inhibits vWF-platelet interaction, and Crizanlizumab, which, by inhibiting P-selectin binding to its ligands, prevents leukocyte recruitment and platelet aggregation at the site of vascular damage

The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males

The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated in HEK293 cells transfected with TLR3L412F-encoding plasmid and stimulated with specific agonist poly(I:C). A statistically significant reduced survival at 28 days was shown in L412F COVID-19 patients treated with the autophagy-inhibitor hydroxychloroquine (p = 0.038). An increased frequency of autoimmune disorders such as co-morbidity was found in L412F COVID-19 males with specific class II HLA haplotypes prone to autoantigen presentation. Our analyses indicate that L412F polymorphism makes males at risk of severe COVID-19 and provides a rationale for reinterpreting clinical trials considering autophagy pathways. Abbreviations: AP: autophagosome; AUC: area under the curve; BafA1: bafilomycin A1; COVID-19: coronavirus disease-2019; HCQ: hydroxychloroquine; RAP: rapamycin; ROC: receiver operating characteristic; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TLR: toll like receptor; TNF/TNF-α: tumor necrosis factor