15 research outputs found

    G0_POLS_indData

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    Basal blood glucose concentration and body mass data from wild (free-living) passerine birds (songbirds) collected in the field. Life-history traits related to reproduction rate/fecundity (clutch size, egg mass, clutch frequency), migration distance, diet and basal metabolic rate data collected from the literature. Maximum lifespan data taken from EURING databank

    Data from: Fuel for the pace of life: baseline blood glucose concentration coevolves with life history traits in songbirds

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    1. It has been proposed that life histories have coevolved with a suite of physiological and behavioural adaptations, termed pace-of-life syndromes (POLS). Here, we hypothesise that basal concentration of blood glucose (G0), a major source of energy circulating in vertebrate blood, may constitute a key component of POLS. 2. To test this hypothesis, we measured G0 in 30 passerine species and tested its covariation with body mass and other life history traits. Importantly, body mass is a major life history determinant and, when its effect is controlled for, there may be no single fast-slow life history continuum in birds comprising both fecundity and lifespan. Hence, we used individual life history traits, rather than principal component analysis, to characterise life history variation in our analysis. 3. In support of G0 life history coevolution, we found G0 to be negatively correlated with body mass and positively with reproductive investment in a single clutch across 30 passerine species. Higher G0 in females suggests that the energy demands of clutch production and incubation may be an important selection force driving coevolution of G0 with reproductive output. 4. In contrast, G0 was not associated with maximum lifespan, suggesting that high G0 may not constrain evolution of longevity. This implies that long-lived species can evolve physiological adaptations preventing harmful effects of high glucose concentrations, known to cause pathologies and accelerate ageing. 5. In addition, G0, but not basal metabolic rate (BMR), was negatively correlated with migration distance, attesting to evolutionary changes in energy metabolism in long distance migrants. Our results further suggest that the links between body mass, reproduction and G0 are not mediated by BMR and that G0 is associated with fast-slow life history variation more closely than available BMR data. 6. A species life history is determined to a great extent by body mass. When this effect is controlled for, only those traits related to reproduction (but not lifespan) constitute the principal axis of life history variation in birds. Hence, the coevolution of G0 with body mass and reproductive output evidenced in our study indicates that G0 constitutes an important physiological component of POLS

    Rho/Rho-associated kinase pathway in glaucoma

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    Development of a Large Pixel Chip Demonstrator in RD53 for ATLAS and CMS Upgrades

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    RD53A is a large scale 65 nm CMOS pixel demonstrator chip that has been developed by the RD53 collaboration for very high rate (3 GHz/cm2) and very high radiation levels (500 Mrad, possibly 1 Grad) for ATLAS and CMS phase 2 upgrades. It features serial powering operation and design variations in the analog and digital pixel matrix for different testing purposes. The design and verification of RD53A are described together with an outline of the plans to develop final pixel chips for the two experiments

    Hyperon signatures in the PANDA experiment at FAIR

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    We present a detailed simulation study of the signatures from the sequential decays of the triple-strange pbar p -> Ω+Ω- -> K+ΛbarK- Λ -> K+pbarπ+K-pπ- process in the PANDA central tracking system with focus on hit patterns and precise time measurement. We present a systematic approach for studying physics channels at the detector level and develop input criteria for tracking algorithms and trigger lines. Finally, we study the beam momentum dependence on the reconstruction efficiency for the PANDA detector

    ILC Reference Design Report Volume 4 - Detectors

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    This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics.This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics

    ILC Reference Design Report Volume 3 - Accelerator

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    The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2 s^-1. The complex includes a polarized electron source, an undulator-based positron source, two 6.7 km circumference damping rings, two-stage bunch compressors, two 11 km long main linacs and a 4.5 km long beam delivery system. This report is Volume III (Accelerator) of the four volume Reference Design Report, which describes the design and cost of the ILC.The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2 s^-1. The complex includes a polarized electron source, an undulator-based positron source, two 6.7 km circumference damping rings, two-stage bunch compressors, two 11 km long main linacs and a 4.5 km long beam delivery system. This report is Volume III (Accelerator) of the four volume Reference Design Report, which describes the design and cost of the ILC
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