4,220 research outputs found
Nature and origin of fine laminated sediments from the western Nile Delta: high resolution elemental content and lithology
Gender Differences in Response to a School-Based Mindfulness Training Intervention for Early Adolescents
Mindfulness training has been used to improve emotional wellbeing in early adolescents. However, little is known about treatment outcome moderators, or individual differences that may differentially impact responses to treatment. The current study focused on gender as a potential moderator for affective outcomes in response to school-based mindfulness training. Sixth grade students (NâŻ=âŻ100) were randomly assigned to either the six weeks of mindfulness meditation or the active control group as part of a history class curriculum. Participants in the mindfulness meditation group completed short mindfulness meditation sessions four to five times per week, in addition to didactic instruction (Asian history). The control group received matched experiential activity in addition to didactic instruction (African history) from the same teacher with no meditation component. Self-reported measures of emotional wellbeing/affect, mindfulness, and self-compassion were obtained at pre and post intervention. Meditators reported greater improvement in emotional wellbeing compared to those in the control group. Importantly, gender differences were detected, such that female meditators reported greater increases in positive affect compared to females in the control group, whereas male meditators and control males displayed equivalent gains. Uniquely among females but not males, increases in self-reported self-compassion were associated with improvements in affect. These findings support the efficacy of school-based mindfulness interventions, and interventions tailored to accommodate distinct developmental needs of female and male adolescents
The decay of turbulence in rotating flows
We present a parametric space study of the decay of turbulence in rotating
flows combining direct numerical simulations, large eddy simulations, and
phenomenological theory. Several cases are considered: (1) the effect of
varying the characteristic scale of the initial conditions when compared with
the size of the box, to mimic "bounded" and "unbounded" flows; (2) the effect
of helicity (correlation between the velocity and vorticity); (3) the effect of
Rossby and Reynolds numbers; and (4) the effect of anisotropy in the initial
conditions. Initial conditions include the Taylor-Green vortex, the
Arn'old-Beltrami-Childress flow, and random flows with large-scale energy
spectrum proportional to . The decay laws obtained in the simulations for
the energy, helicity, and enstrophy in each case can be explained with
phenomenological arguments that separate the decay of two-dimensional from
three-dimensional modes, and that take into account the role of helicity and
rotation in slowing down the energy decay. The time evolution of the energy
spectrum and development of anisotropies in the simulations are also discussed.
Finally, the effect of rotation and helicity in the skewness and kurtosis of
the flow is considered.Comment: Sections reordered to address comments by referee
Plans and progress towards tuning the ATF2 final focus system to obtain a 35 nm IP waist
FR5PFP021International audienceUsing a new extraction line currently being commissioned, the ATF2 experiment plans to test a novel compact ïŹnal focus optics design using a local chromaticity correction scheme, such as could be used in future linear colliders*. Using a 1.3 GeV beam of âŒ30nm normalised vertical emittance extracted from the ATF damping ring, the primary goal is to achieve a vertical IP waist of 35nm. We discuss our planned strategy, implementation details and early experimental results for tuning the ATF2 beam to meet the primary goal. These optics require uniquely tight tolerances on some magnet strengths and positions, we discuss eïŹorts to re-match the optics to meet these requirements using high-precision measurements of key magnet elements. We simulated in detail the tuning procedure using several algorithms and diïŹerent code implementations for comparison from initial orbit establishment to ïŹnal IP spot-size tuning. Through a Monte Carlo study of 100's of simulation seeds we ïŹnd we can achieve a spot-size within 10% of the design optics value in at least 90% of cases. We also ran a simulation to study the long-term performance with the use of beam-based feedbacks
Decreasing trend and changing indications of hysterectomy in Finland
Introduction Hysterectomy has been one of the most common surgical procedures in women in Finland. We studied the population-based trends of hysterectomy and its indications from 1986 to 2017. Material and methods A retrospective population-based cohort was created from the Care Register for Health Care by identifying women who had a hysterectomy from 1986 to 2017 and calculating the number of women from the Digital and Population Data Services Agency. We estimated the number and incidence of hysterectomy by period and age as well as by indication. We considered the primary diagnosis at the time of surgery as the indication of hysterectomy. Results The number of hysterectomies increased from 7492 procedures in 1986 to 12 404 procedures in 1998, and reduced substantially after that to 5971 procedures in 2017, the turning point being in 1999. The incidence rate of hysterectomy has decreased on average by 2.5% annually from 432.6 per 100 000 women in 1998-2001 to 224.5 per 100 000 women in 2014-2017. The median age at the time of hysterectomy has increased from 51 years in 1998-2001 to 55 years in 2014-2017. The cumulative burden of hysterectomy by age of 60 years has nearly halved from the first 4-year period (23%) to the last (12%). After 2010, the most common indication has been genital prolapse and incontinence, whereas earlier it was uterine fibroids. Conclusions The number and incidence of hysterectomies have fluctuated during the observation period 1986-2017 and decreased considerably during the past 17 years in Finland. This is probably a result of the availability of hormonal and other conservative treatment options for bleeding disorders and uterine fibroids. As hysterectomy practically removes the risk for endometrial cancer, the change in hysterectomy incidence over time emphasizes the importance of correcting endometrial cancer incidence according to hysterectomy incidence.Peer reviewe
Dopamine D 4 Receptor-Deficient Mice Display Cortical Hyperexcitability
The dopamine D(4) receptor (D(4)R) is predominantly expressed in the frontal cortex (FC), a brain region that receives dense input from midbrain dopamine (DA) neurons and is associated with cognitive and emotional processes. However, the physiological significance of this dopamine receptor subtype has been difficult to explore because of the slow development of D(4)R agonists and antagonists the selectivity and efficacy of which have been rigorously demonstrated in vivo. We have attempted to overcome this limitation by taking a multidimensional approach to the characterization of mice completely deficient in this receptor subtype. Electrophysiological current and voltage-clamp recordings were performed in cortical pyramidal neurons from wild-type and D(4)R-deficient mice. The frequency of spontaneous synaptic activity and the frequency and duration of paroxysmal discharges induced by epileptogenic agents were increased in mutant mice. Enhanced synaptic activity was also observed in brain slices of wild-type mice incubated in the presence of the selective D(4)R antagonist PNU-101387G. Consistent with greater electrophysiological activity, nerve terminal glutamate density associated with asymmetrical synaptic contacts within layer VI of the motor cortex was reduced in mutant neurons. Taken together, these results suggest that the D(4)R can function as an inhibitory modulator of glutamate activity in the FC.Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de Investigaciones en IngenierĂa GenĂ©tica y BiologĂa Molecular "Dr. HĂ©ctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Cepeda, Carlos. University of California at Los Angeles; Estados UnidosFil: Hurst, Raymond S.. University of California at Los Angeles; Estados UnidosFil: Flores Hernandez, Jorge. University of California at Los Angeles; Estados UnidosFil: Ariano, Marjorie A.. The Chicago Medical School; Estados UnidosFil: Falzone, Tomas Luis. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de Investigaciones en IngenierĂa GenĂ©tica y BiologĂa Molecular "Dr. HĂ©ctor N. Torres"; ArgentinaFil: Kozell, Laura B.. Oregon Health Sciences University; Estados UnidosFil: Meshul, Charles K.. Oregon Health Sciences University; Estados UnidosFil: Bunzow, James R.. Oregon Health Sciences University; Estados UnidosFil: Low, Malcolm J.. Oregon Health Sciences University; Estados UnidosFil: Levine, Michael S.. University of California at Los Angeles; Estados UnidosFil: Grandy, David K.. Oregon Health Sciences University; Estados Unido
The decay of Batchelor and Saffman rotating turbulence
The decay rate of isotropic and homogeneous turbulence is known to be
affected by the large-scale spectrum of the initial perturbations, associated
with at least two cannonical self-preserving solutions of the von
K\'arm\'an-Howarth equation: the so-called Batchelor and Saffman spectra. The
effect of long-range correlations in the decay of anisotropic flows is less
clear, and recently it has been proposed that the decay rate of rotating
turbulence may be independent of the large-scale spectrum of the initial
perturbations. We analyze numerical simulations of freely decaying rotating
turbulence with initial energy spectra (Batchelor turbulence) and
(Saffman turbulence) and show that, while a self-similar decay
cannot be identified for the total energy, the decay is indeed affected by
long-range correlations. The decay of two-dimensional and three-dimensional
modes follows distinct power laws in each case, which are consistent with
predictions derived from the anisotropic von K\'arm\'an-Howarth equation, and
with conservation of anisotropic integral quantities by the flow evolution
Cancer Incidence and Mortality in the Oldest Old: a Nationwide Study in Finland
The world's population is aging rapidly. This study reports the burden of cancer in the oldest old (â„85 years) in Finland in 1953-2017 and estimates age-specific cancer rates in the old population (65-99 years) in 1988-2017. The Finnish Cancer Registry provided data on all cancer diagnoses, cancer deaths and other deaths in cancer patients in Finland in 1953-2017. Between 1953-1957 and 2013-2017, the proportion of incident cancers in those aged â„85 years increased from 1.5% to 9.6% (597 to 15,360 new cases), and in 2013-2017, more new cancers were diagnosed at age â„85 years than age <50 years. Cancer incidence and excess mortality attributable to cancer peaked at age 85-94 years and declined subsequently, whereas cancer-specific mortality continued to increase or plateaued. Due to demographic changes, the number of new cancers in the oldest old has increased substantially in Finland, and currently, nearly one in 10 cancers are diagnosed in this age group. The increasing cancer burden in the oldest old poses a major challenge for healthcare and needs to be addressed in designing clinical research and reporting of cancer registries. In old populations with competing risks of death, we propose excess cancer mortality as a measure of cancer-related mortality.Peer reviewe
Indirect Detection of Kaluza-Klein Dark Matter from Latticized Universal Dimensions
We consider Kaluza-Klein dark matter from latticized universal dimensions. We
motivate and investigate two different lattice models, where the models differ
in the choice of boundary conditions. The models reproduce relevant features of
the continuum model for Kaluza-Klein dark matter. For the model with simple
boundary conditions, this is the case even for a model with only a few lattice
sites. We study the effects of the latticization on the differential flux of
positrons from Kaluza-Klein dark matter annihilation in the galactic halo. We
find that for different choices of the compactification radius, the
differential positron flux rapidly converges to the continuum model results as
a function of the number of lattice sites. In addition, we consider the
prospects for upcoming space-based experiments such as PAMELA and AMS-02 to
probe the latticization effect.Comment: 25 pages, 9 figures, LaTeX. Final version published in JCA
Towards a new generation axion helioscope
We study the feasibility of a new generation axion helioscope, the most
ambitious and promising detector of solar axions to date. We show that large
improvements in magnetic field volume, x-ray focusing optics and detector
backgrounds are possible beyond those achieved in the CERN Axion Solar
Telescope (CAST). For hadronic models, a sensitivity to the axion-photon
coupling of \gagamma\gtrsim {\rm few} \times 10^{-12} GeV is
conceivable, 1--1.5 orders of magnitude beyond the CAST sensitivity. If axions
also couple to electrons, the Sun produces a larger flux for the same value of
the Peccei-Quinn scale, allowing one to probe a broader class of models. Except
for the axion dark matter searches, this experiment will be the most sensitive
axion search ever, reaching or surpassing the stringent bounds from SN1987A and
possibly testing the axion interpretation of anomalous white-dwarf cooling that
predicts of a few meV. Beyond axions, this new instrument will probe
entirely unexplored ranges of parameters for a large variety of axion-like
particles (ALPs) and other novel excitations at the low-energy frontier of
elementary particle physics.Comment: 37 pages, 11 figures, accepted for publication in JCA
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