Scapular fractures associated with acromioclavicular and sternoclavicular luxation

Fractures of the scapula used to be among rare injuries, but in the last two decades their number has increased. Fractures of the scapula can be isolated, but in 67-92% they are combined with injuries to other structures of the shoulder girdle. The dissertation was divided into two parts: experimental and clinical. In the experimental part, the aim was to describe the occurrence and variants of sulcus coracoglenoidalis (CGN) and sulcus arteriae circumflexae scapulae (SCF). These two little-known structures play an important role in the occurrence of some types of scapula fractures and in their surgical treatment. Combined scapular injuries with AC and SC dislocation are rare. Therefore, in the clinical part, we decided to identify and describe in detail combined injuries of the scapula with AC and SC dislocation, including a detailed description of fractures of coracoid process. Anatomical studies were performed on 330 dry bone specimens of adult scapulas. Clinical studies were conducted on a set of 519 scapula fractures in adult patients occurring in the period 2002-2020. In the anatomical part of the dissertation, two anatomical structures were described for the first time: CGN and SCF. Our studies pointed to considerable variability in the occurrence and degree of formation of both of these...Zlomeniny lopatky patřily dříve mezi vzácná poranění, v posledních dvou desetiletích však jejich počet vzrostl. Zlomeniny lopatky mohou být izolované, ale v 67-92 % jsou kombinované s poraněním dalších struktur ramenního pletence. Disertační práce byla rozdělena do dvou částí: experimentální a klinické. V experimentální části bylo cílem popsat výskyt a varianty sulcus coracoglenoidalis (CGN) a sulcus arteriae circumflexae scapulae (SCF). Tyto dvě málo známé struktury hrají významnou roli při vzniku některých typů zlomenin lopatky i při jejich operační léčbě. Kombinovaná poranění lopatky s AC a SC luxací jsou vzácná. Proto jsme se v klinické části rozhodli identifkovat a podrobně popsat kombinovaná poranění lopatky s AC a SC luxací, a to včetně podrobného popisu zlomenin proc. coracoideus. Anatomické studie byly provedeny na 330 suchých kostěných preparátech dospělých lopatek. Klinické studie byly provedeny na souboru 519 zlomenin lopatky u dospělých pacientů vzniklém v období 2002-2020. V anatomické části disertační práce byly poprvé popsány dvě anatomické struktury, které v literatuře byly dosud zmíněny pouze okrajově, a to sulcus coracoglenoidalis a sulcus arteriae circumflexae scapulae. Naše studie poukázaly na značnou variabilitu ve výskytu i míře vytvoření obou těchto žlábků a upozornily na...Ústřední vojenská nemocnice - Vojenská fakultní nemocnice PrahaMilitary University Hospital PragueFirst Faculty of Medicine1. lékařská fakult

The influence of some factors of competitiveness on business risks

The impact of significant competition factors on the riskiness of business risk in the SMEs sector in the Czech Republic and Slovak Republic. The empirical research was constructed on the basis a questionnaire. The attitudes from 641 entrepreneurs from two countries were collected during the year 2018. The statistical hypotheses were evaluated using quantitative methods. The multiple linear regression models were used to evaluate the impact of the competitive environment and of the narrow business environment on the perception of the riskiness of business risk according to entrepreneurs. The conclusions ofthe research showed an interesting finding. The authors found that the competitive environment, as well as the narrower business environment, affects the perception of the riskiness of business risk. It has also been shown that my customers accept the prices of my products and services. This is the most important indicator of a competitive environment. The most important indicator of a narrower business environment is that my customers support me in doing business. The authors believe that the article has brought several interesting findings and new incentives for the further research and discussion regarding to the perception of enterprise risk not only in the selected countries this research. © 2020 The Author(s)

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors.

Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR. We have recently identified cyclin-dependent kinase 5 (Cdk5) as novel alternative and pharmacologically accessible target in the context of angiogenesis. In the present work we demonstrate that trisubstituted pyrazolo[4,3-d]pyrimidines constitute a novel class of compounds which potently inhibit angiogenesis. All seven tested compounds inhibited endothelial cell proliferation with IC(50) values between 1 and 18 µM. Interestingly, this seems not to be due to cytotoxicity, since none of them showed acute cytotoxic effects on endothelial cells at a concentration of 10 µM,. The three most potent compounds (LGR1404, LGR1406 and LGR1407) also inhibited cell migration (by 27, 51 and 31%, resp.), chemotaxis (by 50, 70 and 60% in accumulative distance, resp.), and tube formation (by 25, 60 and 30% of total tube length, resp.) at the non-toxic concentration of 10 µM. Furthermore, angiogenesis was reduced in vivo in the CAM assay by these three compounds. A kinase selectivity profiling revealed that the compounds prevalently inhibit Cdk2, Cdk5 and Cdk9. The phenotype of the migrating cells (reduced formation of lamellipodia, loss of Rac-1 translocation to the membrane) resembles the previously described effects of silencing of Cdk5 in endothelial cells. We conclude that especially LGR1406 and LGR1407 are highly attractive anti-angiogenic compounds, whose effects seem to largely depend on their Cdk5 inhibiting properties

The Cytokinin Status of the Epidermis Regulates Aspects of Vegetative and Reproductive Development in Arabidopsis thaliana

The epidermal cell layer of plants has important functions in regulating plant growth and development. We have studied the impact of an altered epidermal cytokinin metabolism on Arabidopsis shoot development. Increased epidermal cytokinin synthesis or breakdown was achieved through expression of the cytokinin synthesis gene LOG4 and the cytokinin-degrading CKX1 gene, respectively, under the control of the epidermis-specific AtML1 promoter. During vegetative growth, increased epidermal cytokinin production caused an increased size of the shoot apical meristem and promoted earlier flowering. Leaves became larger and the shoots showed an earlier juvenile-to-adult transition. An increased cytokinin breakdown had the opposite effect on these phenotypic traits indicating that epidermal cytokinin metabolism can be a factor regulating these aspects of shoot development. The phenotypic consequences of abbreviated cytokinin signaling in the epidermis achieved through expression of the ARR1-SRDX repressor were generally milder or even absent indicating that the epidermal cytokinin acts, at least in part, cell non-autonomously. Enhanced epidermal cytokinin synthesis delayed cell differentiation during leaf development leading to an increased cell proliferation and leaf growth. Genetic analysis showed that this cytokinin activity was mediated mainly by the AHK3 receptor and the transcription factor ARR1. We also demonstrate that epidermal cytokinin promotes leaf growth in a largely cell-autonomous fashion. Increased cytokinin synthesis in the outer layer of reproductive tissues and in the placenta enhanced ovule formation by the placenta and caused the formation of larger siliques. This led to a higher number of seeds in larger pods resulting in an increased seed yield per plant. Collectively, the results provide evidence that the cytokinin metabolism in the epidermis is a relevant parameter determining vegetative and reproductive plant growth and development

Proposal and realization of physical activities convenient into a busy part of a PE lesson

Práce je zaměřena na návrhy rušných částí do hodin tělesné výchovy pro střední školy. První tři kapitoly diplomové práce tvoří teoretickou část a stávají se východiskem pro znalosti k části praktické. Ta se zabývá jednotlivými návrhy rušných částí. Návrhy mají název podle náčiní nebo nářadí v ní použité. Realizace byla uskutečněna a vyhodnocena na základní škole praktické v Chebu. Součástí jednotlivých návrhů je videozáznam. Práce slouží jedincům zabývající se pohybovou aktivitou, jako sborník nápadů, jak vést vhodně začátek pohybové činnosti.ObhájenoThe thesis is focused on drafts of dynamic parts of the physical education lessons for high school. The first three chapters of the thesis are a theoretical parts crucial for understanding the practical part. The practical part deals with individual drafts of dynamic parts of the physical education lessons. These drafts are called by equipment or tools used in it. Realization was carried out and evaluated in basic practical school in Cheb. Component of each individual draft is video. The thesis should help people interested in physical activity, such as a collection of ideas how to run correctly beginning of physical activity

Physical handicap and recreational physical activities in the Pilsen region

Téma mé bakalářské práce je Rekreační a pohybová aktivita tělesně postižených v Plzeňském kraji. Cílem bakalářské práce bylo seznámit veřejnost se situací rekreačních pohybových aktivit tělesně postižených v Plzeňském kraji. Shromážděním teoretických informací a sestavením dotazníků pro centra jsem získal důležitá data pro vyhodnocení mého šetření. Výsledkem bylo zjištění možností pohybových aktivit pro tělesně postižené v Plzeňském kraji.Katedra tělesné a sportovní výchovyObhájenoThe topic of my thesis is Recreational physical activities for the disabled in the Pilsen region. The aim of this study was to publicize the situation of recreational physical activity disabled in the Pilsen Region. I got the important data for the evaluation of my investigation by a gathering of theoretical information and constructing questionnaires for centers. The result was the identification of options of physical activities for disabled people in the Pilsen region

The process of Setting Up the Local Government in the Municipality of Kutná Hora

This thesis deals with local politics in a specific municipality in the Czech Republic. First part of this thesis is focused on theoretical basics of this topic. This part contains summarization of definitions of basic terms and mechanisms that local politics is based on. Second part of this thesis is focused on the municipality of Kutná Hora. It contains characteristics of the municipality and application of theoretical findings to the specific municipality. The aim is to identify factors influencing function of the local government. The qualitative method of research was used in this thesis, especially half-structuralized interviews with eight local politicians

Zpracování základního plánu části obce Písečná tachymetrickým měřením v měřítku 1:500 (příp. 1:1000)

Import 21/04/2006Prezenční výpůjčkaVysoká škola báňská. Fakulta hornicko-geologická. Katedra (528) důlního měřictví a geodézi

Scapular fractures associated with acromioclavicular and sternoclavicular luxation

Fractures of the scapula used to be among rare injuries, but in the last two decades their number has increased. Fractures of the scapula can be isolated, but in 67-92% they are combined with injuries to other structures of the shoulder girdle. The dissertation was divided into two parts: experimental and clinical. In the experimental part, the aim was to describe the occurrence and variants of sulcus coracoglenoidalis (CGN) and sulcus arteriae circumflexae scapulae (SCF). These two little-known structures play an important role in the occurrence of some types of scapula fractures and in their surgical treatment. Combined scapular injuries with AC and SC dislocation are rare. Therefore, in the clinical part, we decided to identify and describe in detail combined injuries of the scapula with AC and SC dislocation, including a detailed description of fractures of coracoid process. Anatomical studies were performed on 330 dry bone specimens of adult scapulas. Clinical studies were conducted on a set of 519 scapula fractures in adult patients occurring in the period 2002-2020. In the anatomical part of the dissertation, two anatomical structures were described for the first time: CGN and SCF. Our studies pointed to considerable variability in the occurrence and degree of formation of both of these..