187 research outputs found
Some remarks on the isoperimetric problem for the higher eigenvalues of the Robin and Wentzell Laplacians
We consider the problem of minimising the th eigenvalue, , of
the (-)Laplacian with Robin boundary conditions with respect to all domains
in of given volume . When , we prove that the second
eigenvalue of the -Laplacian is minimised by the domain consisting of the
disjoint union of two balls of equal volume, and that this is the unique domain
with this property. For and , we prove that in many cases a
minimiser cannot be independent of the value of the constant in the
boundary condition, or equivalently of the volume . We obtain similar
results for the Laplacian with generalised Wentzell boundary conditions .Comment: 16 page
The heart of a convex body
We investigate some basic properties of the {\it heart}
of a convex set It is a subset of
whose definition is based on mirror reflections of euclidean
space, and is a non-local object. The main motivation of our interest for
is that this gives an estimate of the location of the
hot spot in a convex heat conductor with boundary temperature grounded at zero.
Here, we investigate on the relation between and the
mirror symmetries of we show that
contains many (geometrically and phisically) relevant points of
we prove a simple geometrical lower estimate for the diameter of
we also prove an upper estimate for the area of
when is a triangle.Comment: 15 pages, 3 figures. appears as "Geometric Properties for Parabolic
and Elliptic PDE's", Springer INdAM Series Volume 2, 2013, pp 49-6
Second-order -regularity in nonlinear elliptic problems
A second-order regularity theory is developed for solutions to a class of
quasilinear elliptic equations in divergence form, including the -Laplace
equation, with merely square-integrable right-hand side. Our results amount to
the existence and square integrability of the weak derivatives of the nonlinear
expression of the gradient under the divergence operator. This provides a
nonlinear counterpart of the classical -coercivity theory for linear
problems, which is missing in the existing literature. Both local and global
estimates are established. The latter apply to solutions to either Dirichlet or
Neumann boundary value problems. Minimal regularity on the boundary of the
domain is required. If the domain is convex, no regularity of its boundary is
needed at all
On the regularity up to the boundary for certain nonlinear elliptic systems
We consider a class of nonlinear elliptic systems and we prove regularity up to the boundary for second order derivatives. In the proof we trace carefully the dependence on the various parameters of the problem, in order to establish, in a further work, results for more general systems
The Spherically Symmetric Standard Model with Gravity
Spherical reduction of generic four-dimensional theories is revisited. Three
different notions of "spherical symmetry" are defined. The following sectors
are investigated: Einstein-Cartan theory, spinors, (non-)abelian gauge fields
and scalar fields. In each sector a different formalism seems to be most
convenient: the Cartan formulation of gravity works best in the purely
gravitational sector, the Einstein formulation is convenient for the Yang-Mills
sector and for reducing scalar fields, and the Newman-Penrose formalism seems
to be the most transparent one in the fermionic sector. Combining them the
spherically reduced Standard Model of particle physics together with the
usually omitted gravity part can be presented as a two-dimensional (dilaton
gravity) theory.Comment: 58 pages, 2 eps figure
Pathological consequences of VCP mutations on human striated muscle
*These authors have contributed equally to this work. Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (IBMPFD). We report on the pathological consequences of three heterozygous VCP (R93C, R155H, R155C) mutations on human striated muscle. IBMPFD skeletal muscle pathology is characterized by degenerative changes and filamentous VCP-and ubiquitin-positive cytoplasmic and nuclear protein aggregates. Furthermore, this is the first report demonstrating that mutant VCP leads to a novel form of dilatative cardiomyopathy with inclusion bodies. In contrast to post-mitotic striated muscle cells and neurons of IBMPFD patients, evidence of protein aggregate pathology was not detected in primary IBMPFD myoblasts or in transient and stable transfected cells using wild-type-VCP and R93C-, R155H-, R155C-VCP mutants. Glutathione S-transferase pull-down experiments showed that all three VCP mutations do not affect the binding to Ufd1, Npl4 and ataxin-3. Structural analysis demonstrated that R93 and R155 are both surface-accessible residues located in the centre of cavities that may enable ligand-binding. Mutations at R93 and R155 are predicted to induce changes in the tertiary structure of the VCP protein. The search for putative ligands to the R93 and R155 cavities resulted in the identification of cyclic sugar compounds with high binding scores. The latter findings provide a novel link to VCP carbohydrate interactions in the complex pathology of IBMPFD. Keywords: VCP; p97; myopathy; cardiomyopathy; IBMPFD Abbreviations: GST = glutathione S-transferase; IBMPFD = inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia; PBS = phosphate-buffered saline; SDS = sodium dodecyl sulphate; VCP = valosin-containing protei
Twenty years of coordination technologies: State-of-the-art and perspectives
Since complexity of inter- and intra-systems interactions is steadily increasing in modern application scenarios (e.g., the IoT), coordination technologies are required to take a crucial step towards maturity. In this paper we look back at the history of the COORDINATION conference in order to shed light on the current status of the coordination technologies there proposed throughout the years, in an attempt to understand success stories, limitations, and possibly reveal the gap between actual technologies, theoretical models, and novel application needs
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