Prognosis off the pre-eclampsia development and it’s severity in pregnant women using mathematic model, based on the blood level of the regulatory auto-antibodies

Modern comprehension of the preeclampsia makes us to consider this complication as the complex problem, in the basis of which lie immune-complex disturbances and endoteliosis in the utero-placentar blood system. The estimation of these disturbances is possible using the blood level of the regulatory auto-antibodies measurement. This study evaluates in the prospective manner the link between the level of those auto-antibodies (at the beginning of the pregnancy period) and the probability of the preeclampsia formation in the pregnant patients, as well as the severity of this complication. The analysis included 202 pregnant women. The analysis let us to create a mathematical prognostic model for the prediction of the preeclampsia and it’s severity with high accuracy. By means of this model it is now possible to identify those patients who are at risk of the preeclampsia, which warrants the necessary therapy in advance to prevent the serious consequences.В современном представлении преэклампсия является сложной акушерской патологией, в основе которой лежат иммуно-комплексные нарушения и эндотелиоз в бассейне маточно-плацентарного кровотока. Оценка степени нарушений в работе иммунной системы возможна за счет определения уровня регуляторных аутоантител в крови у беременных пациенток. В данном исследовании проспективно было оценено влияние уровня регуляторных аутоантител, определяемых в ранние сроки беременности, на вероятность развития преэклампсии и степень ее тяжести. Исследование проведено на 202 беременных пациентках. На основании полученной информации была создана математическая модель прогноза развития преэклампсии и тяжести этого осложнения с высокими общими показателями точности. Использование прогностической модели позволит выявлять пациенток с высокой вероятностью развития преэклампсии на ранних сроках беременности и своевременно принимать лечебные меры

Разреженная декомпозиция скеилограммы вибрации для мониторинга технического состояния роторного оборудования

The article describes an algorithm for the sparse decomposition of vibration signals scalogram for searching of the frequency domains with a significant energy contribution. The developed algorithm is proposed to be used for monitoring the technical condition of rotary equipment. The article presents the testing results of the sparse scalegram decomposition algorithm on the vibration signals of industrial equipment.В статье рассмотрен алгоритм разреженной декомпозиции скейлограммы вибрационных сигналов для поиска частотных областей со значительным энергетическим вкладом. Разработанный алгоритм предложено использовать для мониторинга технического состояния роторного оборудования. В статье приведены результаты тестирования алгоритма разреженной декомпозиции скейлограммы на сигналах вибрации промышленного оборудования

Эхолокация рукокрылых (Chiroptera Blumenbach, 1779) как элемент их экологической пластичности

Aim. The aim of this work was to briefly summarize the current understanding of the phenomenon of echolocation in the order of bats (Chiroptera Blumenbach, 1779). Discussion. The paper discusses: The place of bats among other taxonomic groups of animals that have the ability of echolocation; the history of the discovery of "ear vision" in bats by L. Spallanzani in the 18th century; the first scientifically based assumptions regarding the use of ultrasound by bats and the discovery of this phenomenon in the middle of the last century; methods for emitting and receiving ultrasound by various taxonomic groups of bats; physical patterns underlying the propagation of ultrasonic waves; characteristics of the returned echo and algorithms for echolocation in bats; echolocation interactions between insectivorous bats and nocturnal moths and possibilities for ultrasonic monitoring of bat populations. Conclusion. The inclusion of ultrasound monitoring of bat populations in integrated ecological and virological studies could form a new point of growth in systems to ensure biological security at both national and global levels. © 2020 Kamerton. All rights reserved

Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas

Urachal cancer (UrC) is a rare but aggressive malignancy often diagnosed in advanced stages requiring systemic treatment. Although cytotoxic chemotherapy is of limited effectiveness, prospective clinical studies can hardly be conducted. Targeted therapeutic treatment approaches and potentially immunotherapy based on a biological rationale may provide an alternative strategy. We therefore subjected 70 urachal adenocarcinomas to targeted next-generation sequencing, conducted in situ and immunohistochemical analyses (including PD-L1 and DNA mismatch repair proteins (MMR)) and evaluated the microsatellite instability (MSI) status. The analytical findings were correlated with clinicopathological and outcome data and Kaplan-Meier and univariable/multivariable Cox regression analyses were performed. The patients had a mean age of 50 years, 66% were male and a 5-year overall survival (OS) of 58% and recurrence-free survival (RFS) of 45% was detected. Sequence variations were observed in TP53 (66%), KRAS (21%), BRAF (4%), PIK3CA (4%), FGFR1 (1%), MET (1%), NRAS (1%), and PDGFRA (1%). Gene amplifications were found in EGFR (5%), ERBB2 (2%), and MET (2%). We detected no evidence of MMR-deficiency (MMR-d)/MSI-high (MSI-h), whereas 10 of 63 cases (16%) expressed PD-L1. Therefore, anti-PD-1/PD-L1 immunotherapy approaches might be tested in UrC. Importantly, we found aberrations in intracellular signal transduction pathways (RAS/RAF/PI3K) in 31% of UrCs with potential implications for anti-EGFR therapy. Less frequent potentially actionable genetic alterations were additionally detected in ERBB2 (HER2), MET, FGFR1, and PDGFRA. The molecular profile strengthens the notion that UrC is a distinct entity on the genomic level with closer resemblance to colorectal than to bladder cancer. This article is protected by copyright. All rights reserved

The clinical relevance of oliguria in the critically ill patient : Analysis of a large observational database

Funding Information: Marc Leone reports receiving consulting fees from Amomed and Aguettant; lecture fees from MSD, Pfizer, Octapharma, 3 M, Aspen, Orion; travel support from LFB; and grant support from PHRC IR and his institution. JLV is the Editor-in-Chief of Critical Care. The other authors declare that they have no relevant financial interests. Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.publishersversionPeer reviewe

Drug-induced liver injury-significance of pathology

Many different medical agents, herbal products, and dietary supplements can induce drug-induced liver injury (DILI) as a clinically relevant complication. DILI, which is direct toxic or idiosyncratic, can have a broad spectrum of clinical appearances from elevation of liver enzymes to acute liver failure. DILI is categorized clinically according to the pattern of serum parameters or pathologically according to the pattern of histomorphology. Histopathological patterns can be described as hepatitic, granulomatous, cholestatic, ductopenic, fibrotic, steatotic, steatohepatitic, and vascular. Correlation to the corresponding drug can be carried out with the corresponding databases (US National Library of Medicine, Liver Tox;). Liver biopsy, in contrast to a clinical/serological diagnostic, has the advantage of an exact resolution with evidence of pathophysiology, activity, regeneration, chronification, and prognosis. Co-occurrence of underlying liver disease can be excluded or confirmed. Histological patterns of DILI are described and illustrated. A diagnostic algorithm for the interpretation of liver biopsies is provided