125 research outputs found
Influence of state of health and personality factors of resilience and coping in healthy subjects and those with diabetes
Genome-Wide Expression in Visceral Adipose Tissue from Obese Prepubertal Children
Characterization of the genes expressed in adipose tissue (AT) is key to understanding the pathogenesis of obesity and to developing treatments for this condition. Our objective was to compare the gene expression in visceral AT (VAT) between obese and normal-weight prepubertal children. A total of fifteen obese and sixteen normal-weight children undergoing abdominal elective surgery were selected. RNA was extracted from VAT biopsies. Microarray experiments were independently performed for each sample (six obese and five normal-weight samples). Validation by quantitative PCR (qPCR) was performed on an additional 10 obese and 10 normal-weight VAT samples. Of 1276 differentially expressed genes (p < 0.05), 245 were more than two-fold higher in obese children than in normal-weight children. As validated by qPCR, expression was upregulated in genes involved in lipid and amino acid metabolism (CES1, NPRR3 and BHMT2), oxidative stress and extracellular matrix regulation (TNMD and NQO1), adipogenesis (CRYAB and AFF1) and inflammation (ANXA1); by contrast, only CALCRL gene expression was confirmed to be downregulated. In conclusion, this study in prepubertal children demonstrates the up- and down-regulation of genes that encode molecules that were previously proposed to influence the pathogenesis of adulthood obesity, as well as previously unreported dysregulated genes that may be candidate genes in the aetiology of obesity.This work was supported by Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (FONDOS FEDER) Projects no PI 020826 and PI051968 and Redes temáticas de investigación cooperativa RETIC (Red SAMID RD12/0026/0015). CG-L is a recipient of a fellowship from Plan Propio UGR
Clinical Care Guidelines for Cystic Fibrosis–Related Diabetes: A position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society
Cystic fibrosis related diabetes—a new perspective on the optimal management of postprandial glycemia
The Utilization of 99mTc-Sn·EHDP Bone Scanning Agent for Detection and Clinical Progress of Abnormal Bone Metabolism: A Case Report1
La Tuberculosis como Infeccion Asociada al VIH
La infección oportunista más comúnmente asociada al Virus de la Inmunodeficiencia Humana (VIH) es la Tuberculosis (TB), formando estas dos patologías una co-infección. La asociación de ambas enfermedades es conocida como “coepidemia” o “epidemia dual”. Provoca grandes problemáticas ya que ambas infecciones se intensifican y es más mortal que cada una de ellas por separado.
Para el tratamiento de esta co-infección es importante que sea considerada como una sola enfermedad y no como dos separadas a fin de poder abordarla de manera eficaz. Para el tratamiento se desarrolla una combinación de medicamentos Antirretrovirales (ART) y antituberculosos. Esta interacción tiene el riesgo de producir efectos adversos siendo el más común el Síndrome de Reconstrucción Inmune (SRI).
Para evitar la coepidemia, las estrategias de prevención juegan un papel importante a fin de que no se produzca el desarrollo y propagación de la misma. Se conocen posibles estrategias a nivel de diagnóstico y tratamiento preventivo encontrándose todas ellas todavía en fase de investigación.
Un papel base en el tratamiento y la prevención es la información que se realiza no sólo al paciente sino a sus allegados. En este aspecto es muy importante el papel de la Enfermería
An investigation of the effect of the quantity of stannous ion on the quality of technetium-99m labelled albumin
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