Pain and Function in the Runner a Ten (din) uous Link

A male runner (30 years old; 10-km time: 33 min, 46 sec) had been running with suspected insertional Achilles tendinopathy (AT) for ~2 years when the pain reached a threshold that prevented running. Diagnostic ultrasound (US), prior to a high-volume stripping injection, confirmed right-sided medial insertional AT. The athlete failed to respond to injection therapy and ceased running for a period of 5 weeks. At the beginning of this period, the runner completed the Victoria institute of sports assessment-Achilles questionnaire (VISA-A), the foot and ankle disability index (FADI), and FADI sport prior to undergoing an assessment of bi-lateral gastrocnemius medialis (GM) muscle architecture (muscle thickness (MT) and pennation angle (PA); US), muscle contractile properties (maximal muscle displacement (Dm) and contraction time (Tc); Tensiomyography (TMG)) and calf endurance (40 raises/min). VISA-A and FADI scores were 59%/100% and 102/136 respectively. Compared to the left leg, the right GM had a lower MT (1.60 cm vs. 1.74 cm), a similar PA (22.0° vs. 21.0°), a lower Dm (1.2 mm vs. 2.0 mm) and Tc (16.5 ms vs. 17.7 ms). Calf endurance was higher in the right leg compared to the left (48 vs. 43 raises). The athlete began a metronome-guided (15 BPM), 12-week progressive eccentric training protocol using a weighted vest (1.5 kg increments per week), while receiving six sessions of shockwave therapy concurrently (within 5 weeks). On returning to running, the athlete kept daily pain (Numeric Rating Scale; NRS) and running scores (miles*rate of perceived exertion (RPE)). Foot and ankle function improved according to scores recorded on the VISA-A (59% vs. 97%) and FADI (102 vs. 127/136). Improvements in MT (1.60 cm vs. 1.76 cm) and PA (22.0° vs. 24.8°) were recorded via US. Improvements in Dm (1.15 mm vs. 1.69 mm) and Tc (16.5 ms vs. 15.4 ms) were recorded via TMG. Calf endurance was lower in both legs and the asymmetry between legs remained (L: 31, R: 34). Pain intensity (mean weekly NRS scores) decreased between week 1 and week 12 (6.6 vs. 2.9), while running scores increased (20 vs. 38) during the same period. The program was maintained up to week 16 at which point mean weekly NRS was 2.2 and running score was 47

Measuring subdiffusion parameters

We propose a method to extract from experimental data the subdiffusion parameter $\alpha$ and subdiffusion coefficient $D_\alpha$ which are defined by means of the relation $=2D_\alpha/\Gamma(1+\alpha) t^\alpha$ where $$ denotes a mean square displacement of a random walker starting from $x=0$ at the initial time $t=0$. The method exploits a membrane system where a substance of interest is transported in a solvent from one vessel to another across a thin membrane which plays here only an auxiliary role. Using such a system, we experimentally study a diffusion of glucose and sucrose in a gel solvent. We find a fully analytic solution of the fractional subdiffusion equation with the initial and boundary conditions representing the system under study. Confronting the experimental data with the derived formulas, we show a subdiffusive character of the sugar transport in gel solvent. We precisely determine the parameter $\alpha$, which is smaller than 1, and the subdiffusion coefficient $D_\alpha$.Comment: 17 pages, 9 figures, revised, to appear in Phys. Rev.

Bayesian inference for within-herd prevalence of Leptospira interrogans serovar Hardjo using bulk milk antibody testing

Leptospirosis is the most widespread zoonosis throughout the world and human mortality from severe disease forms is high even when optimal treatment is provided. Leptospirosis is also one of the most common causes of reproductive losses in cattle worldwide and is associated with significant economic costs to the dairy farming industry. Herds are tested for exposure to the causal organism either through serum testing of individual animals or through testing bulk milk samples. Using serum results from a commonly used enzyme-linked immunosorbent assay (ELISA) test for Leptospira interrogans serovar Hardjo (L. hardjo) on samples from 979 animals across 12 Scottish dairy herds and the corresponding bulk milk results, we develop a model that predicts the mean proportion of exposed animals in a herd conditional on the bulk milk test result. The data are analyzed through use of a Bayesian latent variable generalized linear mixed model to provide estimates of the true (but unobserved) level of exposure to the causal organism in each herd in addition to estimates of the accuracy of the serum ELISA. We estimate 95% confidence intervals for the accuracy of the serum ELISA of (0.688, 0.987) and (0.975, 0.998) for test sensitivity and specificity, respectively. Using a percentage positivity cutoff in bulk milk of at most 41% ensures that there is at least a 97.5% probability of less than 5% of the herd being exposed to L. hardjo. Our analyses provide strong statistical evidence in support of the validity of interpreting bulk milk samples as a proxy for individual animal serum testing. The combination of validity and cost-effectiveness of bulk milk testing has the potential to reduce the risk of human exposure to leptospirosis in addition to offering significant economic benefits to the dairy industry

Dust enshrouded star-forming activity in Arp 299

We present mid-infrared spectro-imaging (5 - 16 microns) observations of the infrared luminous interacting system Arp 299 (=Mrk171 =IC694+NGC3690) obtained with the ISOCAM instrument aboard ISO. Our observations show that nearly 40% of the total emission at 7 and 15 microns is diffuse, originating from the interacting disks of the galaxies. Moreover, they indicate the presence of large amounts of hot dust in the main infrared sources of the system and large extinctions toward the nuclei. While the observed spectra have an overall similar shape, mainly composed of Unidentified Infrared Bands (UIB) in the short wavelength domain, a strong continuum at ~ 13 microns and a deep silicate absorption band at 10 microns, their differences reveal the varying physical conditions of each component. For each source, the spectral energy distribution (SED) can be reproduced by a linear combination of a UIB "canonical" spectral template and a hot dust continuum due to a 230-300 K black body, after independently applying an extinction correction to both of them. We find that the UIB extinction does not vary much throughout the system (A_V ~ 5 mag) suggesting that most UIBs originate from less enshrouded regions. IC694 appears to dominate the infrared emission of the system and our observations support the interpretation of a deeply embedded nuclear starburst located behind an absorption of about 40 mag. The central region of NGC3690 displays a hard radiation field characterized by a [NeIII]/[NeII] ratio > 1.8. It also hosts a strong continuum from 5 to 16 microns which can be explained as thermal emission from a deeply embedded (A_V ~ 60 mag) compact source, consistent with the mid-infrared signature of an active galactic nucleus (AGN), and in agreement with recent X-ray findings.Comment: to be published in Astronomy and Astrophysics - 12 page

The Spitzer View of Low-Metallicity Star Formation: III. Fine Structure Lines, Aromatic Features, and Molecules

We present low- and high-resolution Spitzer/IRS spectra, supplemented by IRAC and MIPS measurements, of 22 blue compact dwarf (BCD) galaxies. The BCD sample spans a wide range in oxygen abundance [12+Log(O/H) between 7.4 and 8.3], and hardness of the interstellar radiation field (ISRF). The IRS spectra provide us with a rich set of diagnostics to probe the physics of star and dust formation in very low-metallicity environments. We find that metal-poor BCDs have harder ionizing radiation than metal-rich galaxies: [OIV] emission is roughly 4 times as common as [FeII] emission. They also have a more intense ISRF, as indicated by the 71 to 160micron luminosity ratio. Two-thirds of the sample (15 BCDs) show PAH features, although the fraction of PAH emission normalized to the total infrared (IR) luminosity is considerably smaller in metal-poor BCDs (~0.5%) than in metal-rich star-forming galaxies (~10%). We find several lines of evidence for a deficit of small PAH carriers at low metallicity, and attribute this to destruction by a hard, intense ISRF, only indirectly linked to metal abundance. Our IRS spectra reveal a variety of H2 rotational lines, and more than a third of the objects in our sample (8 BCDs) have >=3sigma detections in one or more of the four lowest-order transitions. The warm gas masses in the BCDs range from 10^3 to 10^8 Msun, and can be comparable to the neutral hydrogen gas mass; relative to their total IR luminosities, some BCDs contain more H2 than SINGS galaxies.Comment: Accepted by ApJ: 70 pages in draft form, 6 tables, 22 figure

The Fine-Scale Structure of the neutral Interstellar Medium in nearby Galaxies

We present an analysis of the properties of HI holes detected in 20 galaxies that are part of "The HI Nearby Galaxy Survey" (THINGS). We detected more than 1000 holes in total in the sampled galaxies. Where they can be measured, their sizes range from about 100 pc (our resolution limit) to about 2 kpc, their expansion velocities range from 4 to 36 km/s, and their ages are estimated to range between 3 and 150 Myr. The holes are found throughout the disks of the galaxies, out to the edge of the HI; 23% of the holes fall outside R25. We find that shear limits the age of holes in spirals (shear is less important in dwarf galaxies) which explains why HI holes in dwarfs are rounder, on average than in spirals. Shear, which is particularly strong in the inner part of spiral galaxies, also explains why we find that holes outside R25 are larger and older. We derive the scale height of the HI disk as a function of galactocentric radius and find that the disk flares up in all galaxies. We proceed to derive the surface and volume porosity (Q2D and Q3D) and find that this correlates with the type of the host galaxy: later Hubble types tend to be more porous. The size distribution of the holes in our sample follows a power law with a slope of a ~ -2.9. Assuming that the holes are the result of massive star formation, we derive values for the supernova rate (SNR) and star formation rate (SFR) which scales with the SFR derived based on other tracers. If we extrapolate the observed number of holes to include those that fall below our resolution limit, down to holes created by a single supernova, we find that our results are compatible with the hypothesis that HI holes result from star formation.Comment: 142 pages, 55 figures, accepted for publication in the Astronomical Journa

MOA-2011-BLG-293Lb: A test of pure survey microlensing planet detections

Because of the development of large-format, wide-field cameras, microlensing surveys are now able to monitor millions of stars with sufficient cadence to detect planets. These new discoveries will span the full range of significance levels including planetary signals too small to be distinguished from the noise. At present, we do not understand where the threshold is for detecting planets. MOA-2011-BLG-293Lb is the first planet to be published from the new surveys, and it also has substantial followup observations. This planet is robustly detected in survey+followup data (Delta chi^2 ~ 5400). The planet/host mass ratio is q=5.3+/- 0.2*10^{-3}. The best fit projected separation is s=0.548+/- 0.005 Einstein radii. However, due to the s-->s^{-1} degeneracy, projected separations of s^{-1} are only marginally disfavored at Delta chi^2=3. A Bayesian estimate of the host mass gives M_L = 0.43^{+0.27}_{-0.17} M_Sun, with a sharp upper limit of M_L < 1.2 M_Sun from upper limits on the lens flux. Hence, the planet mass is m_p=2.4^{+1.5}_{-0.9} M_Jup, and the physical projected separation is either r_perp = ~1.0 AU or r_perp = ~3.4 AU. We show that survey data alone predict this solution and are able to characterize the planet, but the Delta chi^2 is much smaller (Delta chi^2~500) than with the followup data. The Delta chi^2 for the survey data alone is smaller than for any other securely detected planet. This event suggests a means to probe the detection threshold, by analyzing a large sample of events like MOA-2011-BLG-293, which have both followup data and high cadence survey data, to provide a guide for the interpretation of pure survey microlensing data.Comment: 29 pages, 6 figures, Replaced 7/3/12 with the version accepted to Ap