Present Limits to Heat-Adaptability in Corals and Population-Level Responses to Climate Extremes

Climate change scenarios suggest an increase in tropical ocean temperature by 1–3°C by 2099, potentially killing many coral reefs. But Arabian/Persian Gulf corals already exist in this future thermal environment predicted for most tropical reefs and survived severe bleaching in 2010, one of the hottest years on record. Exposure to 33–35°C was on average twice as long as in non-bleaching years. Gulf corals bleached after exposure to temperatures above 34°C for a total of 8 weeks of which 3 weeks were above 35°C. This is more heat than any other corals can survive, providing an insight into the present limits of holobiont adaptation. We show that average temperatures as well as heat-waves in the Gulf have been increasing, that coral population levels will fluctuate strongly, and reef-building capability will be compromised. This, in combination with ocean acidification and significant local threats posed by rampant coastal development puts even these most heat-adapted corals at risk. WWF considers the Gulf ecoregion as “critically endangered”. We argue here that Gulf corals should be considered for assisted migration to the tropical Indo-Pacific. This would have the double benefit of avoiding local extinction of the world's most heat-adapted holobionts while at the same time introducing their genetic information to populations naïve to such extremes, potentially assisting their survival. Thus, the heat-adaptation acquired by Gulf corals over 6 k, could benefit tropical Indo-Pacific corals who have <100 y until they will experience a similarly harsh climate. Population models suggest that the heat-adapted corals could become dominant on tropical reefs within ∼20 years

International longitudinal registry of patients with atrial fibrillation and treated with rivaroxaban: RIVaroxaban Evaluation in Real life setting (RIVER)

Background Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in everyday practice. RIVER (RIVaroxaban Evaluation in Real life setting) is an ongoing international, prospective registry of patients with newly diagnosed non-valvular atrial fibrillation (NVAF) and at least one investigator-determined risk factor for stroke who received rivaroxaban as an initial treatment for the prevention of thromboembolic stroke. The aim of this paper is to describe the design of the RIVER registry and baseline characteristics of patients with newly diagnosed NVAF who received rivaroxaban as an initial treatment. Methods and results Between January 2014 and June 2017, RIVER investigators recruited 5072 patients at 309 centres in 17 countries. The aim was to enroll consecutive patients at sites where rivaroxaban was already routinely prescribed for stroke prevention. Each patient is being followed up prospectively for a minimum of 2-years. The registry will capture data on the rate and nature of all thromboembolic events (stroke / systemic embolism), bleeding complications, all-cause mortality and other major cardiovascular events as they occur. Data quality is assured through a combination of remote electronic monitoring and onsite monitoring (including source data verification in 10% of cases). Patients were mostly enrolled by cardiologists (n = 3776, 74.6%), by internal medicine specialists 14.2% (n = 718) and by primary care/general practice physicians 8.2% (n = 417). The mean (SD) age of the population was 69.5 (11.0) years, 44.3% were women. Mean (SD) CHADS2 score was 1.9 (1.2) and CHA2DS2-VASc scores was 3.2 (1.6). Almost all patients (98.5%) were prescribed with once daily dose of rivaroxaban, most commonly 20 mg (76.5%) and 15 mg (20.0%) as their initial treatment; 17.9% of patients received concomitant antiplatelet therapy. Most patients enrolled in RIVER met the recommended threshold for AC therapy (86.6% for 2012 ESC Guidelines, and 79.8% of patients according to 2016 ESC Guidelines). Conclusions The RIVER prospective registry will expand our knowledge of how rivaroxaban is prescribed in everyday practice and whether evidence from clinical trials can be translated to the broader cross-section of patients in the real world

The Navy's Earth System Prediction Capability: A New Global Coupled Atmosphere-Ocean-Sea Ice Prediction System Designed for Daily to Subseasonal Forecasting

This paper describes the new global Navy Earth System Prediction Capability (Navy-ESPC) coupled atmosphere-ocean-sea ice prediction system developed at the Naval Research Laboratory (NRL) for operational forecasting for timescales of days to the subseasonal. Two configurations of the system are validated: (1) a low-resolution 16-member ensemble system and (2) a high-resolution deterministic system. The Navy-ESPC ensemble system became operational in August 2020, and this is the first time the NRL operational partner, Fleet Numerical Meteorology and Oceanography Center, will provide global coupled atmosphere-ocean-sea ice forecasts, with atmospheric forecasts extending past 16 days, and ocean and sea ice ensemble forecasts. A unique aspect of the Navy-ESPC is that the global ocean model is eddy resolving at 1/12° in the ensemble and at 1/25° in the deterministic configurations. The component models are current Navy operational systems: NAVy Global Environmental Model (NAVGEM) for the atmosphere, HYbrid Coordinate Ocean Model (HYCOM) for the ocean, and Community Ice CodE (CICE) for the sea ice. Physics updates to improve the simulation of equatorial phenomena, particularly the Madden-Julian Oscillation (MJO), were introduced into NAVGEM. The low-resolution ensemble configuration and high-resolution deterministic configuration are evaluated based on analyses and forecasts from January 2017 to January 2018. Navy-ESPC ensemble forecast skill for large-scale atmospheric phenomena, such as the MJO, North Atlantic Oscillation (NAO), Antarctic Oscillation (AAO), and other indices, is comparable to that of other numerical weather prediction (NWP) centers. Ensemble forecasts of ocean sea surface temperatures perform better than climatology in the tropics and midlatitudes out to 60 days. In addition, the Navy-ESPC Pan-Arctic and Pan-Antarctic sea ice extent predictions perform better than climatology out to about 45 days, although the skill is dependent on season

The DrugAge database of aging-related drugs

10.1111/acel.12585Aging Cell163594-59

Reduced arousals following obstructive apneas in infants sleeping prone

SCOPUS: ar.jinfo:eu-repo/semantics/publishe