Global well-posedness of a conservative relaxed cross diffusion system

We prove global existence in time of solutions to relaxed conservative cross diffusion systems governed by nonlinear operators of the form $u_i\to \partial_tu_i-\Delta(a_i(\tilde{u})u_i)$ where the $u_i, i=1,...,I$ represent $I$ density-functions, $\tilde{u}$ is a spatially regularized form of $(u_1,...,u_I)$ and the nonlinearities $a_i$ are merely assumed to be continuous and bounded from below. Existence of global weak solutions is obtained in any space dimension. Solutions are proved to be regular and unique when the $a_i$ are locally Lipschitz continuous

A proteome-scale map of the human interactome network

PMCID: PMC4266588.-- et al.Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ∼14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ∼30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a >broader> human interactome network than currently appreciated. The map also uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help >connect the dots> of the genomic revolution.This work was supported primarily by NHGRI grant R01/U01HG001715 awarded to M.V., D.E.H., F.P.R., and J.T. and in part by the following grants and agencies: NHGRI P50HG004233 to M.V., F.P.R., and A.-L.B.; NHLBI U01HL098166 subaward to M.V.; NHLBI U01HL108630 subaward to A.-L.B.; NCI U54CA112962 subaward to M.V.; NCI R33CA132073 to M.V.; NIH RC4HG006066 to M.V., D.E.H., and T.H.; NICHD ARRA R01HD065288, R21MH104766, and R01MH105524 to L.M.I.; NIMH R01MH091350 to L.M.I. and T.H.; NSF CCF-1219007 and NSERC RGPIN-2014-03892 to Y.X.; Canada Excellence Research Chair, Krembil Foundation, Ontario Research Fund–Research Excellence Award, Avon Foundation, grant CSI07A09 from Junta de Castilla y Leon (Valladolid, Spain), grant PI12/00624 from Ministerio de Economia y Competitividad (AES 2012, ISCiii, Madrid, Spain), and grant i-Link0398 from Consejo Superior de Investigaciones Científicas (CSIC, Madrid, Spain) to J.D.L.R.; Spanish Ministerio de Ciencia e Innovación (BIO2010-22073) and the European Commission through the FP7 project SyStemAge grant agreement n: 306240 to P.A.; Group-ID Multidisciplinary Research Partnerships of Ghent University, grant FWO-V G.0864.10 from the Fund for Scientific Research-Flanders and ERC Advanced Grant N° 340941 to J.T.; EMBO long-term fellowship to A.K.; Institute Sponsored Research funds from the Dana-Farber Cancer Institute Strategic Initiative to M.V. I.L. is a postdoctoral fellow with the FWO-V. M.V. is a “Chercheur Qualifié Honoraire” from the Fonds de la Recherche Scientifique (FRS-FNRS, Wallonia-Brussels Federation, Belgium). Since performing the work described, C. Fontanillo has become an employee of Celgene Research SL, part of the Celgene Corporation.Peer Reviewe

Prediction of subplastidial localization of chloroplast proteins from spectral count data - Comparison of machine learning algorithms

To study chloroplast metabolism and functions, subplastidial localization is a prerequisite to achieve protein functional characterization. As the accurate localization of many chloroplast proteins often remains hypothetical, we set up a proteomics strategy in order to assign the accurate subplastidial localization. A comprehensive study of Arabidopsis thaliana chloroplast proteome has been carried out in our group [1], involving high performance mass spectrometry analyses of highly fractionated chloroplasts. In particular, spectral count data were acquired for the three major chloroplast sub-fractions (stroma, thylakoids and envelope) obtained by sucrose gradient purification. As the distribution of spectral counts over compartments is a fair predicator of relative abundance of proteins [2], it was justified to propose a prime statistical model [1] relating spectral counts to subplastidial localization. This predictive model was based on a logistic regression, and demonstrated an accuracy rate of 84% for chloroplast proteins. In the present work, we conducted a comparative study of various machine learning techniques to generate a predictive model of subplastidial localization of chloroplast proteins based on spectral count data

Towards a formal semantics for AADL execution model

International audienceIn this paper, we present a specification in TLA+ of an AADL execution model. This formal specification is used forderiving a prototype verification tool for AADL the TOPCASED development environment

Bat Occupancy Estimates and Species Richness at Cache River National Wildlife Refuge

Six bat species of special concern, threatened or endangered, may occur in one of Arkansas’ largest bottomland hardwood forests, the Cache River National Wildlife Refuge (CRNWR). However, inventory of bat species throughout the refuge has been lacking and management plans may not be adequate in promoting bat conservation. The objectives of this study were to inventory bat species in the CRNWR, and determine bat-habitat associations via occupancy estimates. From May–August 2014 and 2015, we mist-netted from sunset for 5 hours. We also deployed bioacoustic devices throughout 5 habitat types (cypress-tupelo [dominantly Taxodium distichum and Nyssa aquatica], emergent wetland, mature forest, hardwood reforestation, and managed hardwood). Mist-netting yielded 460 bat captures with Rafinesque’s big-eared bats (Corynorhinus rafinesquii; n = 156) being the most common capture, followed by eastern red bats (Lasiurus borealis; n = 104), southeastern myotis (Myotis austroriparius; n = 91), evening bats (Nycticeius humeralis; n = 58), tri-colored bats (Perimyotis subflavus; n = 54), and a big-brown bat (Eptesicus fuscus; n = 1). Based on 3,896 calls identified with 85% certainty, evening bats and rarer big-brown bats tended to occupy managed hardwood forests more than any other habitat (occupancy probabilities ± SE: Ψ = 0.75 ± 0.13 and 0.38 ± 0.19, respectively). Tri-colored bats tended to be more present in mature forest habitats (Ψ = 0.91 ± 0.09), and Myotis species tended to have highest occupancy rates in cypress-tupelo stands (Ψ = 0.59 ± 0.15). Not all species were detected with both methods. Thus, we encourage future studies to combine mist-netting and acoustic surveying methods to minimize bias in species presence estimate. This would ensure management practices that would benefit all present species

Atypical antipsychotic therapy in Parkinson's disease psychosis: A retrospective study.

ObjectiveParkinson's disease psychosis (PDP) is a frequent complication of idiopathic Parkinson's disease (iPD) with significant impact on quality of life and association with poorer outcomes. Atypical antipsychotic drugs (APDs) are often used for the treatment of PDP; however, their use is often complicated by adverse drug reactions (ADRs). In this study, we present patients with PDP who were treated with the most commonly used atypical antipsychotic agents and review their respective ADRs.MethodsA retrospective study was carried out to include a total of 45 patients with iPD who visited a movement disorders clinic between 2006 and 2015. All PDP patients treated with atypical APDs were included in the analysis for their specific ADRs.ResultsForty-five iPD patients (mean age of onset: 62.67 ± 9.86 years) were included, of those 10 patients had psychosis (mean age of onset: 76.80 ± 4.61 years). Of the 45 patients, 22.2% were found to have psychotic symptoms, of whom 70% had hallucinations, 20% had delusions, and 10% illusions. Seventy percent of psychotic symptoms occurred after ten or more years from diagnosis of iPD. PDP patients were treated with quetiapine, olanzapine, and risperidone separately or in combination, all of which were found to have certain ADRs.LimitationsThis study was limited by its retrospective study design and small sample size and with likely selection bias.ConclusionsThe prevalence of PDP is relatively high in older patients with iPD. The uses of the currently available atypical APDs in this patient population are often complicated by ADRs. The selective 5-HT 2A inverse agonist, pimavanserin, could be a better alternative in the treatment of PDP

CubeSat GPS Observation of Traveling Ionospheric Disturbances After the 2022 Hunga-Tonga Hunga-Ha'apai Volcanic Eruption and Its Potential Use for Tsunami Warning

publishedVersio