Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin

The present study is the first intervention study in a well-established, translational mouse model for hyperlipidaemia and atherosclerosis showing that anacetrapib dose-dependently reduces atherosclerosis development and adds to the anti-atherogenic effects of atorvastatin. This effect is mainly ascribed to the reduction in non-HDL-C despite a remarkable increase in HDL-C and without affecting HDL functionality. In addition, anacetrapib improves lesion stabilit

The Limits of Entrapment: The Negotiations on EU Reduction Targets, 2007-11

In 2007, the EU decided to cut greenhouse gas emissions by 20/30 per cent, something which was considered a proof of the EU's willingness to take on high targets independently of others. In the period 2009-11, the EU was debating but could not reach an agreement on stepping up to a 30 per cent reduction target. This raises the question: why did the EU go from being capable of adopting high targets independently of others to being incapable of agreeing whether it should increase its mitigation effort? It is argued that whereas actors sceptical of a high target could be rhetorically entrapped in 2007, such entrapment was impossible in the 2009-11 period. The lack of entrapment can be explained in terms of changes in the international and socio-economic contexts, which led to changes in the policy processes and the normative environment, which again made effective entrapment impossible

Toward a theory of restraint

Consumption largely remains a black box in the population, environment, and global change debates. The dominant perspective takes insatiability as axiomatic and assumes that reduced consumption will only happen through scarcity or the impositions of external authority. Yet humans often exhibit resource limiting behavior that is not the result of external controls nor is it altruistic or aberrant. This article develops the concept of restraint as an evolutionarily and culturally significant behavior, yet one that in modern times has been relegated to a regressive, if not trivial, status. The article defines restraint, hypothesizes its historical and evolutionary roots, lays out the conditions under which it can occur, and develops a theoretical parallel to cooperation in international relations theory.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43491/1/11111_2005_Article_BF02208422.pd

CCR5 Haplotypes and Mother-to-Child HIV Transmission in Malawi

CCR5 and CCR2 gene polymorphisms (SNPs) have been associated with protection against HIV transmission in adults and with delayed progression to AIDS. The CCR5 Delta32 deletion and SNP -2459G are associated with reduced expression of the CCR5 protein.We investigated the association between infant CCR2/CCR5 diplotype and HIV mother to child transmission (MTCT) in Malawi. Blood samples from infants (n = 552) of HIV positive women who received nevirapine were genotyped using a post-PCR multiplex ligase detection reaction and haplotypes were identified based on 8 CCR2/CCR5 SNPs and the open reading frame 32 base pair deletion. Following verification of Hardy-Weinberg equilibrium, log linear regression was performed to examine the association between mutations and MTCT. Overall, protection against MTCT was weakly associated with two CCR5 SNPs, -2459G (Risk ratio [RR], 0.78; confidence interval [CI], 0.54-1.12), and the linked CCR5 -2135T (RR, 0.78; CI, 0.54-1.13). No child carried the CCR5 Delta32 SNP. Maternal Viral Load (MVL) was found to be an effect measure modifier. Among mothers with low MVL, statistically significant protection against MTCT was observed for -2459G (RR, 0.50; CI, 0.27-0.91), and -2135T (RR, 0.51; CI, 0.28-0.92). Statistically significant protection was not found at high MVL.Results from this study suggest that CCR5 SNPs -2459G and -2135T associated with reduced receptor expression protect against MTCT of HIV at low MVLs, whereas high MVLs may over-ride differences in coreceptor availability

Principles for Sustainability: From Cooperation and Efficiency to Sufficiency

If analysts of political and ecological economy take seriously critical trends in environmental degradation and accept social responsibility for contributing to the reversal of such trends, they must go beyond the descriptive and predictive to the prescriptive, beyond marginal environmental improvement to sustainability, beyond cooperation and efficiency to sufficiency.Cooperation and efficiency principles are useful when biophysical underpinnings remain intact. Otherwise, sufficiency principles-restraint, precaution, polluter pays, zero, reverse onus-address the defining characteristics of current trends, namely environmental criticality, risk export, and responsibility evasion. They engage overconsumption. They compel decision-makers to ask when too much resource use or too little regeneration risks important values such as ecological integrity and social cohesion, when material gains now preclude material gains in the future, when consumer gratification or investor reward threatens economic security, when benefits internalized depend on costs externalized. Under sufficiency, one necessarily asks what are the risks, not just in the short term and for immediate beneficiaries, but in the longterm and for the under-represented. Copyright (c) 2003 Massachusetts Institute of Technology.