708 research outputs found
Patient Selection for Downstaging of Hepatocellular Carcinoma Prior to Liver Transplantation Adjusting the Odds?: Adjusting the Odds?
Background and Aims: Morphometric features such as the Milan criteria serve as
standard criteria for liver transplantation (LT) in patients with hepatocellular carcinoma
(HCC). Since it has been recognized that these criteria are too restrictive and do not
adequately display the tumor biology, additional selection parameters are emerging.
Methods: Concise review of the current literature on patient selection for downstaging and
LT for HCC outside the Milan criteria.
Results: The major task in patients outside the Milan criteria is the need for higher granularity
with patient selection, since the benefit through LT is not uniform. The recent literature clearly
shows that beneath tumor size and number, additional selection parameters are useful in the
process of patient selection for and during downstaging. For initial patient selection, the
alpha fetoprotein (AFP) level adds additional information to the size and number of HCC
nodules concerning the chance of successful downstaging and LT. This effect is quantifiable
using newer selection tools like the WE (West-Eastern) downstaging criteria or the
Metroticket 2.0 criteria. Also an initial PET-scan and/or tumor biopsy can be helpful,
especially in the high risk group of patients outside the University of California San
Francisco (UCSF) criteria. After this entry selection, the clinical course during
downstaging procedures concerning the tumor and the AFP response is of paramount
importance and serves as an additional final selection tool
Conclusion: Selection criteria for liver transplantation in HCC patients are becoming more
and more sophisticated, but are still imperfect. The implementation of molecular
knowledge will hopefully support a more specific risk prediction for HCC patients in
the future, but do not provide a profound basis for clinical decision-making at present
Evidence of topological superconductivity in planar Josephson junctions
Majorana zero modes are quasiparticle states localized at the boundaries of
topological superconductors that are expected to be ideal building blocks for
fault-tolerant quantum computing. Several observations of zero-bias conductance
peaks measured in tunneling spectroscopy above a critical magnetic field have
been reported as experimental indications of Majorana zero modes in
superconductor/semiconductor nanowires. On the other hand, two dimensional
systems offer the alternative approach to confine Ma jorana channels within
planar Josephson junctions, in which the phase difference {\phi} between the
superconducting leads represents an additional tuning knob predicted to drive
the system into the topological phase at lower magnetic fields. Here, we report
the observation of phase-dependent zero-bias conductance peaks measured by
tunneling spectroscopy at the end of Josephson junctions realized on a InAs/Al
heterostructure. Biasing the junction to {\phi} ~ {\pi} significantly reduces
the critical field at which the zero-bias peak appears, with respect to {\phi}
= 0. The phase and magnetic field dependence of the zero-energy states is
consistent with a model of Majorana zero modes in finite-size Josephson
junctions. Besides providing experimental evidence of phase-tuned topological
superconductivity, our devices are compatible with superconducting quantum
electrodynamics architectures and scalable to complex geometries needed for
topological quantum computing.Comment: main text and extended dat
Lessons from agriculture for the sustainable management of malaria vectors.
Willem Takken and colleagues argue for the expansion of insecticide monotherapy in malaria control by taking lessons from agriculture and including more sustainable integrated vector management strategies
The Freshman, vol. 1, no. 8
The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students
The Freshman, vol. 1, no. 9
The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students. This issue includes acknowledgement of Bill Floring setting UMaine\u27s record for running the 100-yard dash in 10 seconds
The Freshman, vol. 1, no. 14
The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students. Campus coverage in this issue includes changes in rules governing the Senior Skulls in an effort to create a better spirit among the entire student body, by prohibiting the wearing of knickers, prep school insignia, and sports shoes
The Freshman, vol. 1, no. 10 [issue misnumbered]
The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students. This issue includes an editorial exploring how to maintain self-identity in the face of academic stereotypes
Twirling and Whirling: Viscous Dynamics of Rotating Elastica
Motivated by diverse phenomena in cellular biophysics, including bacterial
flagellar motion and DNA transcription and replication, we study the overdamped
nonlinear dynamics of a rotationally forced filament with twist and bend
elasticity. Competition between twist injection, twist diffusion, and writhing
instabilities is described by a novel pair of coupled PDEs for twist and bend
evolution. Analytical and numerical methods elucidate the twist/bend coupling
and reveal two dynamical regimes separated by a Hopf bifurcation: (i)
diffusion-dominated axial rotation, or twirling, and (ii) steady-state
crankshafting motion, or whirling. The consequences of these phenomena for
self-propulsion are investigated, and experimental tests proposed.Comment: To be published in Physical Review Letter
Maximal Spontaneous Photon Emission and Energy Loss from Free Electrons
Free electron radiation such as Cerenkov, Smith--Purcell, and transition
radiation can be greatly affected by structured optical environments, as has
been demonstrated in a variety of polaritonic, photonic-crystal, and
metamaterial systems. However, the amount of radiation that can ultimately be
extracted from free electrons near an arbitrary material structure has remained
elusive. Here we derive a fundamental upper limit to the spontaneous photon
emission and energy loss of free electrons, regardless of geometry, which
illuminates the effects of material properties and electron velocities. We
obtain experimental evidence for our theory with quantitative measurements of
Smith--Purcell radiation. Our framework allows us to make two predictions. One
is a new regime of radiation operation---at subwavelength separations, slower
(nonrelativistic) electrons can achieve stronger radiation than fast
(relativistic) electrons. The second is a divergence of the emission
probability in the limit of lossless materials. We further reveal that such
divergences can be approached by coupling free electrons to photonic bound
states in the continuum (BICs). Our findings suggest that compact and efficient
free-electron radiation sources from microwaves to the soft X-ray regime may be
achievable without requiring ultrahigh accelerating voltages.Comment: 7 pages, 4 figure
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
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