Predicting exercise motivation and exercise behavior: A moderated mediation model testing the interaction between perceived exercise variety and basic psychological needs satisfaction

Objectives Perceived variety in exercise predicts exercise behavior through autonomous motivation. However, psychological need satisfaction (viz. for competence, autonomy, and relatedness) may moderate the relationship between perceived variety in exercise and exercise behavior (through autonomous motivation). The purpose of the present study was to examine whether the satisfaction of the basic psychological needs in exercise contexts moderates the mediating role of autonomous exercise motivation in the relationship between perceived variety in exercise and exercise behavior. Design Cross-sectional. Method Adults (N = 499) completed an online questionnaire to measure the study variables. Associations were examined using structural equation modeling. Results Psychological need satisfaction moderated the positive indirect relationship between perceived exercise variety and self-reported exercise behavior (via autonomous motivation) such that perceived variety was associated with exercise behavior when psychological need satisfaction scores were lower than average. Conclusions Based on these findings, perceived exercise variety may act as a compensatory source of motivation when psychological need satisfaction is low. In addition to attempting to foster need-supportive exercise contexts, it may be particularly important for exercise promotion specialists to foster the experience of variety among individuals who have lower psychological need satisfaction

Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis

Background: Kinases are key mediators of inflammation, highlighting the potential of kinase inhibitors as treatments for inflammatory disorders. Selective kinase inhibitors, however, have proved disappointing, particularly in the treatment of rheumatoid arthritis and inflammatory bowel disease. Consequently, to improve efficacy, attention has turned to multikinase inhibition. Methods: The activity of a narrow spectrum kinase inhibitor, TOP1210, has been compared with selective kinase inhibitors (BIRB-796, dasatinib and BAY-61-3606) in a range of kinase assays, inflammatory cell assays, and in inflamed biopsies from patients with ulcerative colitis (UC). Effects on recombinant P38α, Src, and Syk kinase activities were assessed using Z-lyte assays (Invitrogen, Paisley, United Kingdom). Anti-inflammatory effects were assessed by measurement of proinflammatory cytokine release from peripheral blood mononuclear cells, primary macrophages, HT29 cells, inflamed colonic UC biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. Results: TOP1210 potently inhibits P38α, Src, and Syk kinase activities. Similarly, TOP1210 demonstrates potent inhibitory activity against proinflammatory cytokine release in each of the cellular assays and the inflamed colonic UC biopsies and myofibroblasts isolated from inflamed colonic UC mucosa. Generally, the selective kinase inhibitors showed limited and weaker activity in the cellular assays compared with the broad inhibitory profile of TOP1210. However, combination of the selective inhibitors led to improved efficacy and potency in both cellular and UC biopsy assays. Conclusions: Targeted, multikinase inhibition with TOP1210 leads to a broad efficacy profile in both the innate and adaptive immune responses, with significant advantages over existing selective kinase approaches, and potentially offers a much improved therapeutic benefit in inflammatory bowel disease

The certification of the mass fraction of carbon in cementite grains in a Fe-C matrix: IRMM-471

The report describes the production and certification of IRMM-471, a reference material certified for the carbon mass fraction of its cementite (Fe3C) grains. The Fe3C grains are dispersed within an iron pearlite matrix and present an average grain diameter between 20 µm and 50 μm. IRMM-471 has been produced and certified in order to be used as calibrant in electron probe micro-analyser (EPMA) for carbon determination in iron and steel products.JRC.D.2-Standards for Innovation and sustainable Developmen

Climate change projections and stratosphere–troposphere interaction

Climate change is expected to increase winter rainfall and flooding in many extratropical regions as evaporation and precipitation rates increase, storms become more intense and storm tracks move polewards. Here, we show how changes in stratospheric circulation could play a significant role in future climate change in the extratropics through an additional shift in the tropospheric circulation. This shift in the circulation alters climate change in regional winter rainfall by an amount large enough to significantly alter regional climate change projections. The changes are consistent with changes in stratospheric winds inducing a change in the baroclinic eddy growth rate across the depth of the troposphere. A change in mean wind structure and an equatorward shift of the tropospheric storm tracks relative to models with poor stratospheric resolution allows coupling with surface climate. Using the Atlantic storm track as an example, we show how this can double the predicted increase in extreme winter rainfall over Western and Central Europe compared to other current climate projection

The NE Atlantic region: a reappraisal of crustal structure, tectonostratigraphy and magmatic evolution: an introduction to the NAG-TEC project

The NE Atlantic region and its continental margins (Fig. 1) hold unique information for understanding many aspects of Earth science, from global geodynamics to palaeoceanography and global environmental change. It also holds some of the world's most important hydrocarbon reserves from the North Sea, along the Atlantic margins of Ireland, Britain and Norway, and into the Arctic in the Barents Sea. Historically, studies in the NE Atlantic were important for establishing many of the key ideas during the early part of the plate tectonic revolution. Linear magnetic anomalies along the Reykjanes Ridge were identified as early as in the 1960s (Heirtzler et al. 1966) and provided strong evidence for the seafloor spreading hypothesis (Dietz 1961), which by then had been established as a new and holistic theory (Ewing & Heezen 1956). At the same time, Iceland was already recognized as an intriguing anomalous entity (Böðvarsson & Walker 1964) and contributed to knowledge about how Earth's magnetic field reversed its polarity through time. The fact that rifting occurs in close association with old sutures and orogenic belts led Wilson to propose that the Atlantic Ocean closed and opened again, establishing the concept of the ‘Wilson tectonic cycle’ (Wilson 1966; Dewey 1969). The North Atlantic continental margins have long been considered as archetypal, and divergent margins world-wide are commonly described as ‘Atlantic-type passive margins’. However, it is now accepted that these so-called ‘passive’ margins remain dynamic long after break-up, including post-rift vertical movements of up to kilometre scale. The type examples for such epeirogenic movements being, once again, the North Atlantic margin

Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1)

Stress-inducible phosphoprotein I (STIP1, STI1 or HOP) is a cochaperone intermediating Hsp70/Hsp90 exchange of client proteins, but it can also be secreted to trigger prion protein-mediated neuronal signaling. Some mothers of children with autism spectrum disorders (ASD) present antibodies against certain brain proteins, including antibodies against STIP1. Maternal antibodies can cross the fetus blood-brain barrier during pregnancy, suggesting the possibility that they can interfere with STIP1 levels and, presumably, functions. However, it is currently unknown whether abnormal levels of STIP1 have any impact in ASD-related behavior. Here, we used mice with reduced (50%) or increased STIP1 levels (fivefold) to test for potential ASD-like phenotypes. We found that increased STIP1 regulates the abundance of Hsp70 and Hsp90, whereas reduced STIP1 does not affect Hsp70, Hsp90 or the prion protein. Interestingly, BAC transgenic mice presenting fivefold more STIP1 show no major phenotype when examined in a series of behavioral tasks, including locomotor activity, elevated plus maze, Morris water maze and five-choice serial reaction time task (5-CSRTT). In contrast, mice with reduced STIP1 levels are hyperactive and have attentional deficits on the 5-CSRTT, but exhibit normal performance for the other tasks. We conclude that reduced STIP1 levels can contribute to phenotypes related to ASD. However, future experiments are needed to define whether it is decreased chaperone capacity or impaired prion protein signaling that contributes to these phenotypes