181 research outputs found
Studies of sidewall boundary layer in the Langley 0.3 meter transonic cryogenic tunnel with and without suction
Boundary layer measurements on the sidewalls of the Langley 0.3 Meter Transonic Cryogenic Tunnel were made to determine the effectiveness of the passive boundary layer bleed system over a Reynolds number range from 20 to 200 x 10 to the sixth power per meter at Mach numbers from 0.30 to 0.76. The tunnel sidewall boundary layer displacement thickness was about 2 percent of the width of the test section without the boundary layer bleed. Measured velocity profiles correlated well with the defect law of Hama. With the boundary layer bleed equivalent to about 2 percent of the test section mass flow, the boundary layer displacement thickness reduced to about 1 percent of the test section width, which is generally considered acceptable for testing airfoils. It was also noticed that effectiveness of the bleed was nearly independent of the Mach number and Reynolds number over the range of conditions tested. A comparison of the measured suction effectiveness of the bleed with the finite difference and integral methods of boundary layer calculation showed good agreement
First-Order Contaminant Removal in the Hyporheic Zone of Streams: Physical Insights from a Simple Analytical Model
A simple analytical model is presented for the removal of stream-borne contaminants by hyporheic exchange across duned or rippled streambeds. The model assumes a steady-state balance between contaminant supply from the stream and first-order reaction in the sediment. Hyporheic exchange occurs by bed form pumping, in which water and contaminants flow into bed forms in high-pressure regions (downwelling zones) and out of bed forms in low-pressure regions (upwelling zones). Model-predicted contaminant concentrations are higher in downwelling zones than upwelling zones, reflecting the strong coupling that exists between transport and reaction in these systems. When flow-averaged, the concentration difference across upwelling and downwelling zones drives a net contaminant flux into the sediment bed proportional to the average downwelling velocity. The downwelling velocity is functionally equivalent to a mass transfer coefficient, and can be estimated from stream state variables including stream velocity, bed form geometry, and the hydraulic conductivity and porosity of the sediment. Increasing the mass transfer coefficient increases the fraction of streamwater cycling through the hyporheic zone (per unit length of stream) but also decreases the time contaminants undergo first-order reaction in the sediment. As a consequence, small changes in stream state variables can significantly alter the performance of hyporheic zone treatment systems
Variable effect of co-infection on the HIV infectivity: Within-host dynamics and epidemiological significance
<p>Abstract</p> <p>Background</p> <p>Recent studies have implicated viral characteristics in accounting for the variation in the HIV set-point viral load (spVL) observed among individuals. These studies have suggested that the spVL might be a heritable factor. The spVL, however, is not in an absolute equilibrium state; it is frequently perturbed by immune activations generated by co-infections, resulting in a significant amplification of the HIV viral load (VL). Here, we postulated that if the HIV replication capacity were an important determinant of the spVL, it would also determine the effect of co-infection on the VL. Then, we hypothesized that viral factors contribute to the variation of the effect of co-infection and introduce variation among individuals.</p> <p>Methods</p> <p>We developed a within-host deterministic differential equation model to describe the dynamics of HIV and malaria infections, and evaluated the effect of variations in the viral replicative capacity on the VL burden generated by co-infection. These variations were then evaluated at population level by implementing a between-host model in which the relationship between VL and the probability of HIV transmission per sexual contact was used as the within-host and between-host interface.</p> <p>Results</p> <p>Our within-host results indicated that the combination of parameters generating low spVL were unable to produce a substantial increase in the VL in response to co-infection. Conversely, larger spVL were associated with substantially larger increments in the VL. In accordance, the between-host model indicated that co-infection had a negligible impact in populations where the virus had low replicative capacity, reflected in low spVL. Similarly, the impact of co-infection increased as the spVL of the population increased.</p> <p>Conclusion</p> <p>Our results indicated that variations in the viral replicative capacity would influence the effect of co-infection on the VL. Therefore, viral factors could play an important role driving several virus-related processes such as the increment of the VL induced by co-infections. These results raise the possibility that biological differences could alter the effect of co-infection and underscore the importance of identifying these factors for the implementation of control interventions focused on co-infection.</p
Modeling denitrification in aquatic sediments
Author Posting. © The Author(s), 2008. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Biogeochemistry 93 (2009): 159-178, doi:10.1007/s10533-008-9270-z.Sediment denitrification is a major pathway of fixed nitrogen loss from aquatic systems. Due to technical difficulties in measuring this process and its spatial and temporal variability, estimates of local, regional and global denitrification have to rely on a combination of measurements and models. Here we review approaches to describing denitrification in aquatic sediments, ranging from mechanistic diagenetic models to empirical parameterizations of nitrogen fluxes across the sediment-water interface. We also present a compilation of denitrification measurements and ancillary data for different aquatic systems, ranging from freshwater to marine. Based on this data compilation we reevaluate published parameterizations of denitrification. We recommend that future models of denitrification use (1) a combination of mechanistic diagenetic models and measurements where bottom waters are temporally hypoxic or anoxic, and (2) the much simpler correlations between denitrification and sediment oxygen consumption for oxic bottom waters. For our data set, inclusion of bottom water oxygen and nitrate concentrations in a multivariate regression did not improve the statistical fit.Financial support for AEG to work on the manuscript came from
NSF NSF-DEB-0423565. KF, DB and DDT acknowledge support from NOAA CHRP
grant NA07NOS4780191
Emerging role of extracellular vesicles in communication of preimplantation embryos in vitro
Off-specular x-ray scattering in Langmuir-Blodgett multilayers of a liquid-crystalline polymer
The effect of surface roughness on the static layer undulations of multilayer films of a side-chain liquid-crystalline polymer has been investigated by off-specular x-ray scattering. The roughness correlation length evaluated from the off-specular data is shown to vary inversely with the average roughness of the multilayer film. The features of the off-specular x-ray scattering are similar to those exhibited by inorganic heterostructural films. © 1995 The American Physical Society
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