Análise da função pulmonar de pacientes com síndrome pós-covid-19 em um hospital universitário

Objetivo: Avaliar o padrão de espirometria de pacientes que persistiram com sintomas respiratórios após a infecção pelo SARS-CoV-2. Métodos: Estudo transversal, observacional e retrospectivo realizado em um único centro, aprovado pelo Comitê de Ética local (número do parecer: 5.120.720). Foram avaliados pacientes submetidos a espirometria devido à Síndrome Pós-Covid, a fim de analisar o padrão espirométrico apresentado. Os seguintes dados foram coletados: identificação do exame, sexo, idade, tempo de sintomas, necessidade de ventilação mecânica,qualidade da espirometria, além dos seguintes parâmetros do exame: CVF, VEF1, VEF1/CVF, VEF 25-75/CVF e VEF 75, avaliando o Limite Inferior da Normalidade, valores pré-broncodilatador e pós-broncodilatador. Resultados: Foram coletados dados de 72 pacientes. Destes, 55,5% apresentaram resultados espirométricos dentro dos limitesnormais. A alteração respiratória mais frequente foi o distúrbio ventilatório obstrutivo, presente em 29,2% dos pacientes. Conclusões: A presença de dispneia em pacientes com espirometria dentro da normalidade pode indicar uma avaliação adicional da função pulmonar, assim como outras etiologias para a dispneia.Objective: Evaluate the spirometry pattern of patients who persisted with respiratory symptoms after infection with SARS-Cov-2. Methods: Cross-sectional, observational, retrospective study in a single center, approved by the local Ethics Committee (registration number: 5,120,720). Patients who underwent spirometry due to Post-Covid Syndrome were evaluated to analyze the spirometric pattern presented. The following were collected: exam identification data, sex, age, symptom time, the need for mechanical ventilation, and quality of spirometry, in addition to the following exam parameters: FVC, FEV1, FEV1/FVC, FEV 25-75/FVC, and FEV 75, evaluating the Lower Limit of Normality, pre-bronchodilator and post-bronchodilator values. Results: Data from 72 patients were collected.Of these, 55.5% of patients had spirometry results within normal limits. The most frequent respiratory alteration was obstructive respiratory disorder, present in 29.2% of the patients. Conclusions: The presence of dyspnea in patients with normal spirometry may indicate further evaluation of lung function and other etiologies for dyspnea

Historical ethnobotany: an overview of selected studies

Historical Ethnobotany is an area of research responsible for understanding past interrelationships between people and plant using written records and iconography. The literature on this topic is scattered, and many of these studies are not recognised as such; therefore, it is difficult to compile historical ethnobotanical data. Accordingly, this study attempted to draw a general picture of the publications in this field. The Scopus, ISI Web of Knowledge and Scirus databases were used to search for articles with such keywords as “Ethnobotany + History” and “Historical Ethnobotany” among others. After the studies were selected, information was extracted that included the continents addressed and historical ages. Most studies encompassed a time frame that began in the Modern Age (54.7%), and 46% of the studies were focused on the American continent. With regard to the nature of the source, 98% of the studies included written records, and publications that used the documental analysis as a secondary data in their scope of research were among the most frequent types of studies that were found. In respect to iconographic sources, paintings were used in 6% of the studies. A total of 66% of the studies involved a species or species group as the study object. Our survey revealed the vast scope of these Historical Ethnobotany studies. We believe that this scientific field has great potential for future development and that its findings will only grow in importance considering the current ethnobotanical debateFil: Silva, Taline Cristina da. Universidade Federal Rural Pernambuco; BrasilFil: Medeiros, Patrícia Muniz. Universidade Federal Da Bahia; BrasilFil: Balcazar, Alejandro Lozano. Universidade Federal Rural Pernambuco; BrasilFil: Sousa, Thiago Antônio de Araújo. Universidade Federal Rural Pernambuco; BrasilFil: Pirondo, Analia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Botánica del Nordeste. Universidad Nacional del Nordeste. Facultad de Ciencias Agrarias. Instituto de Botánica del Nordeste; ArgentinaFil: Medeiros, Maria Franco Trindade. Universidade Federal de Campina Grande; Brasi

Clinical features of resistant and refractories hypertensives submitted to 24-hour ABPM

Ten to twenty percent of patients with hypertension are considered resistant to treatment. Resistant hypertension is one in which the patient cannot be controlled with the use of three drugs at maximum doses, including a diuretic, or when blood pressure (BP) is controlled with the use of four or more anti-hypertensive drugs. Refractory hypertension is an extreme phenotype of resistant hypertension, when the BP cannot be controlled despite the usage of four anti-hypertensives,. PURPOSE- evaluate the clinical profile of resistant and refractory hypertensives by ABPM. METHODS- From January of 2019 to June of 2022, a total of 669 ABPMs were performed at Unicordis., in which three or more drugs were used in the therapy. We divided these patients into three groups: I) patients who achieved BP control with three drugs; II) patients with resistant hypertension  III) patients with refractory hypertension . RESULTS- We observed that 317 had their BP controlled with three drugs (47%), 275 patients (41%) were considered to have resistant hypertension, and 77 patients were in the refractory hypertension group (12%). When we divided the number of patients with refractory hypertension(77) by the sum of patients with resistant and refractory SAH (352), we have that refractory hypertension was present in 21% of the total cases of resistant SAH. CONCLUSIONS- Older ages, male gender, and higher BMI were more present in the resistant group than in the control group. Older ages and higher incidence of DM and COPD were more frequent in the refractory group than in the control group

SARS-CoV-2 in Brazil and Psychosocial Repercussions on Men’s Health: Health Literacy Is Important

This study aimed at analyzing the psychosocial repercussions of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic on the health of men living in Brazil. For this, we carried out a socio-historical and qualitative study, with the participation of 200 men who answered an online questionnaire. The data collected were processed in the NVIVO12® software, structured by the Collective Subject Discourse method, and analyzed from the epidemic disease theoretical framework proposed by Charles Rosenberg. Our results showed that the SARS-CoV-2 pandemic brought about repercussions of different dimensions that compromised the health of men living in Brazil. The repercussions evidenced were behavioral changes and emergence of new habits due to the pandemic; uncomfortable family situations; impaired affective and sexual relationships; harms in marital relationships; and insecurity and psychological distress. It is important to implement strategies that maximize men’s health literacy, promoting better communication in terms of health, and search for help and suitable information about health/mental health.info:eu-repo/semantics/publishedVersio

High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort

Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded from the analyses. Among the remaining 1638 participants who were seronegative at baseline, 214 showed seroconversion at visit 2. The seroconversion incidence was 13·06% (95% CI 11·52–14·79) overall and 6·78% (5·61–8·10) for symptomatic seroconversion, over a median follow-up period of 57 days (IQR 54–61). 48·1% of seroconversion events were estimated to be asymptomatic. The sample had higher proportions of affluent and higher-educated people than those reported for the Manaus city population. In the fully adjusted and corrected model, risk factors for seroconversion before visit 2 were having a COVID-19 case in the household (IRR 1·49 [95% CI 1·21–1·83]), not wearing a mask during contact with a person with COVID-19 (1·25 [1·09–1·45]), relaxation of physical distancing (1·31 [1·05–1·64]), and having flu-like symptoms (1·79 [1·23–2·59]) or a COVID-19 diagnosis (3·57 [2·27–5·63]) between the first and second visits, whereas working remotely was associated with lower incidence (0·74 [0·56–0·97]). Interpretation: An intense infection transmission period preceded the second wave of COVID-19 in Manaus. Several modifiable behaviours increased the risk of seroconversion, including non-compliance with non-pharmaceutical interventions measures such as not wearing a mask during contact, relaxation of protective measures, and non-remote working. Increased testing in high-transmission areas is needed to provide timely information about ongoing transmission and aid appropriate implementation of transmission mitigation measures. Funding: Ministry of Education, Brazil; Fundação de Amparo à Pesquisa do Estado do Amazonas; Pan American Health Organization (PAHO)/WHO.World Health OrganizationRevisión por pare

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation

Ethics approval and consent to participate The present research pro- posal received approval from our host institution’s review board. In- formed consent was obtained from all individual participants included in the study.Submitted by Éder Freyre ([email protected]) on 2017-02-13T12:36:19Z No. of bitstreams: 1 va_Ludmila_Valverde_etal_CPqGM_2016.pdf: 2347497 bytes, checksum: 35bf55ea0235b751494fcc28a5f1cf60 (MD5)Approved for entry into archive by Éder Freyre ([email protected]) on 2017-02-13T13:01:00Z (GMT) No. of bitstreams: 1 va_Ludmila_Valverde_etal_CPqGM_2016.pdf: 2347497 bytes, checksum: 35bf55ea0235b751494fcc28a5f1cf60 (MD5)Made available in DSpace on 2017-02-13T13:01:00Z (GMT). No. of bitstreams: 1 va_Ludmila_Valverde_etal_CPqGM_2016.pdf: 2347497 bytes, checksum: 35bf55ea0235b751494fcc28a5f1cf60 (MD5) Previous issue date: 2016FAPESB e CNPQFundação Oswaldo Cruz. Centro de Investigação Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Laboratório de Patologia Experimental. Centro de Investigação Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Investigação Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Investigação Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Investigação Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Odontologia. Laboratório de Patologia Cirúrgica Bucal. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Investigação Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Odontologia. Laboratório de Patologia Cirúrgica Bucal. Salvador, BA, Brasil.The present study aimed to evaluate the role of Hedgehog (Hh) molecule expression in association with the clinical aspects of oral squamous cell carcinoma (OSCC), as well as angiogenesis and CD163+ macrophages. Twenty-eight cases of OSCC, nine cases of tumor-free resection margins (TM), and four cases of non-neoplastic oral mucosa (NNM) were submitted to immunohistochemistry to detect proteins Sonic Hedgehog (SHH), Indian Hedgehog (IHH), GLI1, CD163, and CD105. Protein colocalization with respect to SHH/CD163, IHH/CD163, GLI1/CD163, and GLI1/CD105 was assessed by immunohistochemical double staining. In tumor parenchyma, SHH and IHH were present in the cytoplasm of neoplastic cells, while GLI1 was observed in cytoplasm and nucleus. Endothelial cells were found to express SHH, IHH, and GLI1 within CD105+ vessels, and a positive correlation between infiltrating macrophage density (IMD) and microvascular density (MVD) was observed in cases of OSCC and TM. When compared to TM and NNM, the OSCC cases demonstrated higher immunoreactivity for SHH (p = 0.01), IHH (p = 0.39), GLI1 (p = 0.03), IMD (p = 0.0002), and MVD (p = 0.0002). Our results suggest the participation of the Hh pathway in OSCC by way of autocrine and paracrine signaling, in addition to the participation of both SHH and IHH ligands. Endothelial cells were also found to exhibit positivity with respect to Hh pathway components and we surmise that these molecules may play a role in tumor angiogenesis. CD163+ macrophages were also observed to express IHH, a ligand of this pathway, in addition to being associated with tumor neovascularization