The Hybrid Hanger: A lightweight, portable hang-on tree stand with high durability and ease of use.

The Hybrid Hanger is a fully carbon fiber-epoxy composite hang-on tree stand. This 12-pound tree stand design allows a hunter to carry the stand further without fatiguing, which is perfect for public land hunters. In order to support the weight of a person and the harshness of hunting environments, the Hybrid Hanger will need to be strong and weather resistant. It has been tested to 600 pounds and the carbon fiber is an improvement upon the current metal stands of today’s market. Other qualities of the Hybrid Hanger that improve upon current tree stands in the market include: noise reduction, corrosion 41 resistance, and the compact and sleek design. The Hybrid Hanger will also be foldable with backpack straps to easily carry on a hunter’s back as they walk to their hunting location.https://openriver.winona.edu/urc2019/1021/thumbnail.jp

Expanding the clinical phenotype of the 3q29 microdeletion syndrome and characterization of the reciprocal microduplication

<p>Abstract</p> <p>Background</p> <p>Interstitial deletions of 3q29 have been recently described as a microdeletion syndrome mediated by nonallelic homologous recombination between low-copy repeats resulting in an ~1.6 Mb common-sized deletion. Given the molecular mechanism causing the deletion, the reciprocal duplication is anticipated to occur with equal frequency, although only one family with this duplication has been reported.</p> <p>Results</p> <p>In this study we describe 14 individuals with microdeletions of 3q29, including one family with a mildly affected mother and two affected children, identified among 14,698 individuals with idiopathic mental retardation who were analyzed by array CGH. Eleven individuals had typical 1.6-Mb deletions. Three individuals had deletions that flank, span, or partially overlap the commonly deleted region. Although the clinical presentations of individuals with typical-sized deletions varied, several features were present in multiple individuals, including mental retardation and microcephaly. We also identified 19 individuals with duplications of 3q29, five of which appear to be the reciprocal duplication product of the 3q29 microdeletion and 14 of which flank, span, or partially overlap the common deletion region. The clinical features of individuals with microduplications of 3q29 also varied with few common features. <it>De novo </it>and inherited abnormalities were found in both the microdeletion and microduplication cohorts illustrating the need for parental samples to fully characterize these abnormalities.</p> <p>Conclusion</p> <p>Our report demonstrates that array CGH is especially suited to identify chromosome abnormalities with unclear or variable presentations.</p

A Genotype-First Approach for the Molecular and Clinical Characterization of Uncommon De Novo Microdeletion of 20q13.33

Background: Subtelomeric deletions of the long arm of chromosome 20 are rare, with only 11 described in the literature. Clinical features of individuals with these microdeletions include severe limb malformations, skeletal abnormalities, growth retardation, developmental and speech delay, mental retardation, seizures and mild, non-specific dysmorphic features. Methodology/Principal Findings: We characterized microdeletions at 20q13.33 in six individuals referred for genetic evaluation of developmental delay, mental retardation, and/or congenital anomalies. A comparison to previously reported cases of 20q13.33 microdeletion shows phenotypic overlap, with clinical features that include mental retardation, developmental delay, speech and language deficits, seizures, and behavior problems such as autistic spectrum disorder. There does not appear to be a clinically recognizable constellation of dysmorphic features among individuals with subtelomeric 20q microdeletions. Conclusions/Significance: Based on genotype-phenotype correlation among individuals in this and previous studies, we discuss several possible candidate genes for specific clinical features, including ARFGAP1, CHRNA4 and KCNQ2 and neurodevelopmental deficits. Deletion of this region may play an important role in cognitive development

Fully-automated left ventricular mass and volume MRI analysis in the UK Biobank population cohort: evaluation of initial results

Funding was provided by British Heart Foundation (PG/14/89/31194), and by the National Institutes of Health (USA) 1R01HL121754. SN, SKP acknowledge the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at The Oxford University Hospitals Trust at the University of Oxford, and the British Heart Foundation Centre of Research Excellence. Aaron Lee and Steffen Petersen acknowledge support from the NIHR Biomedical Research Centre at Barts Health NHS Trust and from the “SmartHeart” EPSRC programme grant (EP/ P001009/1)

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Chronic Ankle Instability Leads to Lower Extremity Kinematic Changes During Landing Tasks: A Systematic Review

International Journal of Exercise Science 12(1): 24-33, 2019. Ankle and knee injuries are two of the most common injuries. It has been shown that ankle sprains can lead to chronic ankle instability thereby affecting the function of the ankle. Since the lower extremity is a kinetic chain anything that affects the ankle is thought to affect the knee and hip as well. Changes in lower extremity function associated with chronic ankle instability may predispose patients for non-contact ACL injuries. The purpose of this study was to provide a systematic review of the research done on chronic ankle instability (CAI) and lower extremity kinematics during landing tasks. SportsDiscus, PubMed, and CINAHL were used to search “ankle instability” and “landing kinematics.” Included articles must have evaluated patients with chronic ankle instability and have identified kinematic changes at the knee to be included in the review. A total of 338 subjects participated in the six studies identified. The principal findings in these studies were that CAI subjects had decreased knee flexion compared to the control group. Hip flexion was the same between CAI and control groups and dorsiflexion range of motion had mixed results. Patients with chronic ankle instability demonstrate decreased knee flexion. Decreased knee flexion has shown to be a key risk factor in non-contact knee injuries. In the future, more research needs to be done comparing chronic ankle instability to non-contact knee injury rates

Chronic Ankle Instability Leads to Lower Extremity Kinematic Changes During Landing Tasks: A Systematic Review

International Journal of Exercise Science 12(1): 24-33, 2019. Ankle and knee injuries are two of the most common injuries. It has been shown that ankle sprains can lead to chronic ankle instability thereby affecting the function of the ankle. Since the lower extremity is a kinetic chain anything that affects the ankle is thought to affect the knee and hip as well. Changes in lower extremity function associated with chronic ankle instability may predispose patients for non-contact ACL injuries. The purpose of this study was to provide a systematic review of the research done on chronic ankle instability (CAI) and lower extremity kinematics during landing tasks. SportsDiscus, PubMed, and CINAHL were used to search “ankle instability” and “landing kinematics.” Included articles must have evaluated patients with chronic ankle instability and have identified kinematic changes at the knee to be included in the review. A total of 338 subjects participated in the six studies identified. The principal findings in these studies were that CAI subjects had decreased knee flexion compared to the control group. Hip flexion was the same between CAI and control groups and dorsiflexion range of motion had mixed results. Patients with chronic ankle instability demonstrate decreased knee flexion. Decreased knee flexion has shown to be a key risk factor in non-contact knee injuries. In the future, more research needs to be done comparing chronic ankle instability to non-contact knee injury rates