Deformation Effect on Proton Bubble Structure in N = 28 Isotones

Purpose: To study the effect of nuclear deformation on proton bubble structure of N = 28 isotones and and compare it with the spherical limits. The reduction of depletion fraction due to deformation can be explained by studying the relative differences in the central densities.Methods: In this work, we have employed relativistic Hartree-Bogoliubov (RHB) model withdensity-dependent meson-exchange (DD-ME2) interaction and separable pairing interaction. We have performed axially constrained calculations to investigate the deformed proton bubble structure in 40Mg, 42Si, 44S, and 46Ar, isotones of N = 28 shell closure.Results: We have observed that the nuclear deformation play againsts the formation of bubble structure. In the spherical limits, the isotones of N = 28 shell closure have pronounced bubble structure with large value of depletion fraction. But, the increase in deformation leads to the disappearance of bubble structure. The internal densities in deformed nuclei are found to increase with deformation which can be related to the decrease in depletion fraction.Conclusion: By using RHB model, we have investigated the ground state and proton bubble structure of N = 28 isotones. In 44S, and 46Ar, the 2s1/21d3/2 states get inverted due to the weakning of spin-orbit strength. Due to strong dynamical correlations, arising from deformation, the central depletion of proton density is greatly affected in these isotones. The decrease in depletion fraction can be related to increase in the internal density due to deformatio

Nuclear shape evolution and shape coexistence in Zr and Mo isotopes

The phenomena of shape evolution and shape coexistence in even-even $^{88-126}$Zr and $^{88-126}$Mo isotopes is studied by employing covariant density functional theory (CDFT) with density-dependent point coupling parameter sets DD-PCX and DD-PC1, and with separable pairing interaction. The results for rms deviation in binding energies, two-neutron separation energy, the differential variation of two-neutron separation energy, and rms charge radii, as a function of neutron number, are presented and compared with available experimental data. In addition to the oblate-prolate shape coexistence in $^{96-110}$Zr isotopes, the correlation between shape transition and discontinuity in the observables are also examined. A smooth trend of charge radii in Mo isotopes is found to be due to the manifestation of triaxiality softness. The observed oblate and prolate minima are related to the low single-particle energy level density around the Fermi level of neutron and proton respectively. The present calculations also predict a deformed bubble structure in $^{100}$Zr isotope.Comment: this preprint contains incomplete data and some mistake

HIV reactivity trends in a tertiary care teaching hospital in Himachal Pradesh: a ten-year ICTC based retrospective analysis

Background: Despite being a low HIV prevalence nation, India has the third largest number of PLHAs in the world. The study aimed to explore the prevalence, pattern of socio-demographic and epidemiological distribution among HIV sero-positive patients in this part of Himachal Pradesh. Objective was to estimate the prevalence of HIV infection among the clients who had attended the ICTC for a period of ten years, i.e. from 2008 to 2017.Methods: A retrospective descriptive analysis of secondary data from the National AIDS control program from the year 2008 through 2017 was done.Results: Overall prevalence of HIV positivity amongst the clients attending the centre was observed to be 2.1%. Out of the total 55610 clients tested for HIV infection, 40.4% were male, 25.4% were female (excluding ANCs) and 34.2% were Ante-natal cases. Overall, seropositivity was higher among males (58%) than females (40%). However, amongst the groups, higher prevalence has been observed to be present in the females (3.3%) over males (3%) and Ante-natal cases (0.12%). Belonging to the female sex [OR 1.99 (95% CI: 1.77-2.24)] and male sex [OR 2.07 (95% CI: 1.84- 2.33)] had higher odds of having HIV sero-positivity than Ante-natal cases [OR 0.04 (95% CI: 0.02-0.05)]. Heterosexual route of transmission was the major route seen in 70.1%. Maximum HIV seropositivity was in the age group of 25 - 34 years (35.4%).Conclusions: The trends over the last 10 years show no steady pattern. Hence, there is a need for scaled up and sustained efforts focused on the males of reproductive age group for the prevention and control of HIV infection

Efflux in Fungi: La Pièce de Résistance

Pathogens must be able to overcome both host defenses and antimicrobial treatment in order to successfully infect and maintain colonization of the host. One way fungi accomplish this feat and overcome intercellular toxin accumulation is efflux pumps, in particular ATP-binding cassette transporters and transporters of the major facilitator superfamily. Members of these two superfamilies remove many toxic compounds by coupling transport with ATP hydrolysis or a proton gradient, respectively. Fungal genomes encode a plethora of members of these families of transporters compared to other organisms. In this review we discuss the role these two fungal superfamilies of transporters play in virulence and resistance to antifungal agents. These efflux transporters are responsible not only for export of compounds involved in pathogenesis such as secondary metabolites, but also export of host-derived antimicrobial compounds. In addition, we examine the current knowledge of these transporters in resistance of pathogens to clinically relevant antifungal agents

Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019 : a systematic analysis for the Global Burden of Disease Study 2020, Release 1

Background Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. Methods For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dosespecific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in countryreported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. Findings By 2019, global coverage of third-dose DTP (DTP3; 81.6% [95% uncertainty interval 80.4-82 .7]) more than doubled from levels estimated in 1980 (39.9% [37.5-42.1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38.5% [35.4-41.3] in 1980 to 83.6% [82.3-84.8] in 2019). Third- dose polio vaccine (Pol3) coverage also increased, from 42.6% (41.4-44.1) in 1980 to 79.8% (78.4-81.1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from 56.8 million (52.6-60. 9) to 14.5 million (13.4-15.9). However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. Only 11 countries and territories were estimated to have reached the national GVAP target of at least 90% coverage for all assessed vaccines in 2019. Interpretation After achieving large gains in childhood vaccine coverage worldwide, in much of the world this progress was stalled or reversed from 2010 to 2019. These findings underscore the importance of revisiting routine immunisation strategies and programmatic approaches, recentring service delivery around equity and underserved populations. Strengthening vaccine data and monitoring systems is crucial to these pursuits, now and through to 2030, to ensure that all children have access to, and can benefit from, lifesaving vaccines. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Vidi, vini, vinci: External ophthalmomyiasis infection that occurred, and was diagnosed and treated in a single day: A rare case report

Ophthalmomyiasis is an infestation of eye with larvae or maggots of certain flies. Oestrus ovis (sheep nasal botfly) belonging to family Oestridae is the most common cause of human myiasis. We describe here an acute presentation of a case of external ophthalmomyiasis, i.e., infestation of conjunctiva due to first instar larvae of Oestrus ovis. In this case report the occurrence, diagnosis and treatment all took place in the setting of a single day. Prompt treatment by removal of larvae mechanically followed by instillation of antibiotic and steroid eye drops helped to prevent serious complications. The taxonomic identification of fly is also important as some fly species are capable of penetrating deeper tissues of eyes, which is sight threatening

Effect of nuclear deformation on proton bubble structure in

We have studied the density distribution in some “bubble” nuclei. The bubble nuclei are characterized by the depletion of nucleonic density at the center of the nucleus. We have explored the effect of nuclear deformation on proton bubble structure in the Si isotopic chain. The Covariant Density Functional Theory (CDFT) with density-dependent meson-exchange (DD-ME2) interaction has been employed. Triaxially constrained calculations are performed to investigate the deformed bubble structure. Deformation causes the mixing of shells hence reducing the bubble effect in the nuclei. The role of nuclear deformation in nuclear density profiles is explored and compared with the spherical limits

To evaluate and compare analgesic effects of wound infiltration with voveron with intravenous injection in cesarean section

Objectives: Postoperative pain mostly results from sensitization of afferent fibers at injury sites driving central sensitization. Recently, peripheral processes have gained attention as mechanism of hyperalgesia, and prostaglandins are among highly sensitizing agents. To date, postoperative administration of a one single intravenous dose of voveron has shown inconclusive efficacy. Rather than a single intravenous dose, the current study evaluates the postoperative analgesic effect of local injection of voveron sodium after cesarean delivery. Methodology: In a prospective randomized, controlled study, 60 patients age group between 18-35 years, scheduled for routine and emergency cesarean surgery were distributed into two groups of 30 patients each. Postoperatively, group [B] was given voveron in wound local injection and group [A] received voveron 75 mg conventionally as intravenous injections. Pain intensity score, onset of analgesia, rescue analgesia doses and overall patient satisfaction score were recorded. Results: Mean onset of analgesia was 8.31 ± 1.5 min with group A as against 4.23 ± 1.2 min with group B. Pain Intensity (PPI) score ≤ 1 was observed in 78.21% observations belonging to group A and in 50 % observations of group B. Twenty five patients (71.4%) from group A and 30 patients (85.7%) from group B required rescue analgesia. The patient’s feedback was graded as very good or good by 78.5% of the patients in Group-A and 69% patients in Group-B. Conclusion: Though both drugs are equally safe, Voveron in local wound infusion is faster acting, more potent and efficient analgesic than intravenous. voveron when used for postoperative pai