57 research outputs found
Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands
Use of ring-expanded diamino- and diamidocarbene ligands in copper catalyzed azide-alkyne "click" reactions
The
two-coordinate ring-expanded N-heterocyclic carbene copperÂ(I)
complexes [CuÂ(RE-NHC)<sub>2</sub>]<sup>+</sup> (RE-NHC = 6-Mes, 7-<i>o</i>-Tol, 7-Mes) have been prepared and shown to be effective
catalysts under neat conditions for the 1,3-dipolar cycloaddition
of alkynes and azides. In contrast, the cationic diamidocarbene analogue
[CuÂ(6-MesDAC)<sub>2</sub>]<sup>+</sup> and the neutral species [(6-MesDAC)ÂCuCl]<sub>2</sub> and [(6-MesDAC)<sub>2</sub>(CuCl)<sub>3</sub>] show good
activity when the catalysis is performed on water
Low Concentration of Sodium Butyrate from Ultrabraid+NaBu suture, Promotes Angiogenesis and Tissue Remodelling in Tendon-bones Injury
Sodium butyrate (NaBu), a form of short-chain fatty acid (SCFA), acts classically as a potent anti-angiogenic agent in tumour angiogenesis models, some authors demonstrated that low concentrations of NaBu may contribute to healing of tendon-bone injury in part at least through promotion of tissue remodelling. Here, we investigated the effects of low-range concentrations of NaBu using in vitro and in vivo assays using angiogenesis as the primary outcome measure and the mechanisms through which it acts. We demonstrated that NaBu, alone or perfused from the UltraBraid+NaBu suture was pro-angiogenic at very low-range doses promoting migration, tube formation and cell invasion in bovine aortic endothelial cells (BAECs). Furthermore, cell exposure to low NaBu concentrations increased expression of proteins involved in angiogenic cell signalling, including p-PKCÎČ1, p-FAK, p-ERK1/2, p-NFÎșÎČ, p-PLCÎł1 and p-VEGFR2. In addition, inhibitors of both VEGFR2 and PKCÎČ1 blocked the angiogenic response. In in vivo assays, low concentrations of NaBu induced neovascularization in sponge implants in mice, evidenced by increased numbers of vessels and haemoglobin content in these implants. The findings in this study indicate that low concentrations of NaBu could be an important compound to stimulate angiogenesis at a site where vasculature is deficient and healing is compromised
Probing Intermetallic Coupling in Dinuclear N-Heterocyclic Carbene Ruthenium(II) Complexes
Comparaison du mécanisme d'action de l'insuline et de la prolactine
International audienc
A general synthetic route to [Cu(X)(NHC)] (NHC = N-heterocyclic carbene, X = Cl, Br, I) complexes
Synthesis and anticancer activity of silver(I)â N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine
A new library of silver(I)âN-heterocyclic carbene complexes prepared from the natural products caffeine, theophylline and theobromine is reported. The complexes have been fully characterised using a combi- nation of NMR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction analysis. Fur- thermore, the hydrophobicity of the complexes has been measured. The silver(I)âN-heterocyclic carbenes have been evaluated for their antiproliferative properties against a range of cancer cell lines of different histological types, and compared to cisplatin. The data shows different profiles of response when compared to cisplatin in the same panel of cells, indicating a different mechanism of action. Furthermore, it appears that the steric effect of the ligand and the hydrophobicity of the complex both play a role in the chemosensitivity of these compounds, with greater steric bulk and greater hydrophilicity delivering higher cytotoxicity
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