31 research outputs found

    Depression and anxiety in systemic lupus erythematosus: The crosstalk between immunological, clinical, and psychosocial factors

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    Depression and anxiety cause severe loss of quality of life for patients with systemic lupus erythematosus. The causes and factors that contribute to these psychological manifestations in lupus are difficult to disentangle. This study compared clinical, psychological, and demographic factors between lupus patients, depressed patients, and rheumatoid arthritis patients to discover lupus-specific contributors to depression. Lupus-specific manifestations of depression were also investigated. Physiological, clinical, and psychosocial data were collected from 77 patients. ELISA was used to measure cytokine levels. Univariate and Multivariate analyses were used to compare the patient populations and identify correlations between key physical and psychological indicators. The prevalence of depression in the SLE cohort was 6 times greater than the healthy control subjects. Pain, IL-6, and Pittsburgh Sleep Quality index values were all significantly higher in SLE patients compared with the healthy control group (P < .001, P = .038, and P = .005, respectively). Anxiety levels were significantly higher in SLE patients compared to healthy and RA control patients (P = .020 and .011, respectively). Serum IL-10 concentrations, relationship assessment scale, and fatigue severity scale values were found to be correlated with depression among the SLE patients (P = .036, P = .007, and P = .001, respectively). Relationship assessment and fatigue severity scale scores were found to be the best indicators of depression for the SLE patients (P = .042 and .028, respectively). Fatigue Severity, relationship satisfaction, and IL-10 concentrations are indicators of depression in lupus patients. Despite also suffering from the pain and disability that accompanies chronic autoimmune disease, the rheumatoid arthritis patients had less anxiety and better relationship scores.The authors thank the Portugal Fulbright Commission for funding Dr. Pool

    Atmospheric dust deposition and levels of trace elements in an industrial city in the Portuguese coastline

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    O presente estudo pretendeu (i) identificar padrões geoquímicos espaciais e temporais na deposição atmosférica, e (ii) avaliar potenciais contribuições de fontes locais e alóctones para a composição química das poeiras atmosféricas no concelho de Estarreja. Dois coletores foram colocados em áreas exteriores de duas escolas localizadas poucos quilómetros a sul da zona industrial. A recolha das amostras foi realizada mensalmente, de maio a agosto de 2018. As frações solúvel e insolúvel da deposição atmosférica foram analisadas por ICP-MS para determinar as concentrações quase-totais dos elementos químicos. Os resultados mostram a ocorrência de dois eventos distintos de maior fluxo de deposição atmosférica: (i) um em maio, caracterizado pela deposição de elementos traço em formas solúveis, detetado em ambas as escolas e (ii) um segundo em agosto, caracterizado pela deposição de elementos maiores em formas insolúveis, detetado apenas na escola mais distante do complexo industrial. No geral, os resultados indicam uma deposição antrópica de aerossóis em maio e uma deposição de partículas litogénicas em agosto.Due to their high toxicity and reactivity in atmospheric particles, metl(loid)s are a category of pollutants of great concern in air pollution. The present study aimed (i) to identify spatial and temporal geochemical patterns in atmospheric deposition, and (ii) to evaluate potential contributions from local and regional sources to the chemical composition of atmospheric dust, in the industrial city of Estarreja. Two collectors were placed in exterior areas of two schools located few kilometres south from the industrial zone, one within an urban setting and another in a rural environment. Samples were collected monthly from May and August 2018. The soluble and insoluble fractions of atmospheric were analysed by ICP-MS to determine near-total concentrations of the chemical elements. The results indicate two distinct events of higher atmospheric deposition flux. The first event, detected in both schools, occurred in May and is characterized by the deposition of trace elements in soluble forms. The second occurred in August and is characterized by the deposition of major elements in insoluble forms. This later episode was detected only at the school furthest from the industrial complex. Overall, the results indicate an anthropogenic aerosol deposition in May and a lithogenic particle deposition in August.Este trabalho é cofinanciado pela União Europeia através do Fundo Europeu de Desenvolvimento Regional, baseado no COMPETE 2020 (Programa Operacional de Competitividade e Internacionalização), no projeto ICT (UIDB/04683/2020), no projeto GeoBioTec (UIDB/04035/2020) e nos fundos nacionais fornecidos pela Fundação para a Ciência e Tecnologia. Os autores agradecem à Direção, aos docentes e aos funcionários do Agrupamento de Escolas de Estarreja a preciosa colaboração durante o período de recolha das amostra

    The ever-expanding conundrum of primary osteoporosis: aetiopathogenesis, diagnosis, and treatment

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    Performance improvement of fault-tolerant systems through chip-level current monitoring

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    International audienceIn this paper we describe an approach to perform on-line detection of faults induced by ionizing radiation at the system level. In this approach, the leakage current induced by this type of faults can be detected in an early stage of the failure development (i.e. before they cause functional errors or system power-supply breakdown). This ability allows the implementation of fail safe and fault tolerant reconfigurable systems having higher levels of safety and larger lifetime with respect to systems based on conventional techniques. We also describes in this work the implementation and present computer simulation results of a board that will be used to validate the proposed approach. This board contains functional logic monitored by a current sensor, and it will be characterized to radiation during laboratory tests

    Perspectivas dos educadores de infância sobre concepções e práticas da educação ambiental

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    O presente trabalho de investigação pretende dar a conhecer as preocupações que os educadores de infância do arquipélago dos Açores apresentam face à temática da educação ambiental e que representações têm das suas práticas ambientais nas escolas. Tenta-se também perceber quais são as motivações que os levam ou não a desenvolver e/ou estimular a educação ambiental no jardim de infância, tais como as experiências pessoais, a preparação que receberam e que obstáculos identificam. A população inquirida correspondia a 425 educadores, para os quais se enviou um questionário, ao qual responderam 299. A amostra obtida inclui educadores de todas as ilhas dos Açores e na sua maioria corresponde ao género feminino (apenas cinco educadores do sexo masculino). De um modo geral, os educadores inquiridos disseram apoiar e incluir a educação ambiental nas suas aulas de jardim de infância, tendo-se verificado que a idade e as experiências pessoais poderão influenciar a ênfase que dão a esta temática. Os educadores reconhecem que surgem obstáculos no trabalho da educação ambiental, embora tenham mostrado que tentam de alguma forma ultrapassá-los. Por exemplo, quando referiram que receberam uma formação pobre na área da educação ambiental revelaram que as ações de formação e as leituras pessoais, entre outras, podem ajudar a colmatar esta lacuna. A maioria dos inquiridos afirma acreditar que a educação ambiental deverá estar presente em quase todos os projetos de jardim de infância, uma vez que a mudança para uma relação mais equilibrada com o planeta e com as outras espécies depende de todos, independentemente da sua idade. Logo, o jardim de infância será um bom ponto de partida para que as crianças percebam e transmitam (mais tarde) que, ao conservarmos a natureza, estaremos a garantir igualmente a permanência da nossa espécie no planeta.CITA-A; Governo Regional dos Açores

    Applicability of Big Data Techniques to Smart Cities Deployments

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    This paper presents the main foundations of big data applied to smart cities. A general Internet of Things based architecture is proposed to be applied to different smart cities applications. We describe two scenarios of big data analysis. One of them illustrates some services implemented in the smart campus of the University of Murcia. The second one is focused on a tram service scenario, where thousands of transit-card transactions should be processed. Results obtained from both scenarios show the potential of the applicability of this kind of techniques to provide profitable services of smart cities, such as the management of the energy consumption and comfort in smart buildings, and the detection of travel profiles in smart transport.</p
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