Análisis numérico de la convección natural en recintos cerrados con distinto factor de forma

pEn este trabajo se utilizó el análisis numérico, aplicando el programa de simulación para ingeniería ANSYS, para establecer la distribución de temperaturas, densidad y velocidades vertical y horizontal en una cavidad cerrada con relación geométrica alto/ancho (emH/E/em) del sistema de 0.5, 1 y 2, temperatura constante en la pared vertical izquierda y derecha de 50 y 20 °C, respectivamente, y condición de frontera adiabática en las paredes horizontales. Lo anterior para un número de Prandtl de 4.83 y Rayleigh de 5.84x10sup7/sup. Al comparar los resultados entre el sistema con emH/E /em= 2 y emH/E /em= 1, se encontró que el valor máximo positivo de la velocidad vertical se incrementó un 26.29 %, el de la velocidad horizontal disminuyó 72.75 % y la temperatura en la zona central de la cavidad disminuyó un 2.46 %. Por otro lado, al comparar los resultados del sistema emH/E /em= 0.5 y emH/E /em= 1, se encontró que el valor máximo positivo de la velocidad vertical aumentó un 7.24 %, el de la velocidad horizontal se incrementó 34.08 % y la temperatura de la zona central del sistema disminuyó un 3.70 %./pp /pp /ppstrongPalabras claves:/strong Convección natural; Cavidad cerrada; ANSYS/p pDOI: a href="http://dx.doi.org/10.5377/nexo.v24i1.589"http://dx.doi.org/10.5377/nexo.v24i1.589/a/p pNexo, Vol. 24, No. 1, pp. 3-10, 2011/pp /

Numerical analysis of stream function, vorticity and circulation for a rotating flow with rigid boundary

En este trabajo se obtienen y analizan los campos de las funciones vorticidad tangencial, circulación y corriente meridional, que se generan en el interior de un cilindro cerrado que tiene el fondo giratorio y la tapa superior y envolvente sin movimiento. Los resultados se presentan mediante gráficas en las que se comparan dichas funciones, para un número de Reynolds de 3x10 4 y para un factor de forma (alto/radio) del recipiente de 0.5, 1.0 y 2.0. Se encontró al comparar el sistema con relación geométrica 2 respecto al 1, que la función corriente disminuye 29.63%; que la circulación permanece constante y que la vorticidad se reduce un 65.91%. Por otro lado, al comparar el sistema con relación geométrica 0.5 respecto al de 1, se encontró que la función corriente aumenta 1.4 veces, que la circulación se incrementó 3.45 veces y que la vorticidad aumentó 0.7 veces. Los resultados anteriores dan una idea del comportamiento de las funciones corriente, circulación y vorticidad tangencial para las relaciones geométricas antes mencionadas, pero se requiere de un mayor análisis para poder utilizar estos resultados al caso particular de mezclado o de alguna otra aplicación práctica de ingeniería.The tangential vorticity function, circulation and meridian stream that form in a closed rotating cylinder are analyzed. The cylinder has a rotating bottom whereas the lateral surface and the top are fixed. The results are presented as graphs that compare the mentioned functions for different aspect ratios. The comparing aspect ratios: 0.5, 1.0 and 2.0. In comparing the 2.0 aspect ratio versus the 1.0 aspect ratio; it is found that the stream function diminished a 29.63%, whereas the circulation does not change and the vorticity decreases 65.91%. On the other hand comparison of the cylinder with aspect ratio 0.5 against the one with aspect ratio 1; gives that the stream function increases 1.4 times; that the circulation increases 3.45 times and the vorticirty increases 0.7 times. The analysis was made for a 3 x 104 Reynolds number. The mentioned results give an indication of the influence of the aspect ratio as to the motion inside the cylinder. Further investigation is required in order to apply the results to particular conditions of mixing or another practical application.Peer Reviewe

Nanosecond spin lifetimes in single- and few-layer graphene-hBN heterostructures at room temperature

We present a new fabrication method of graphene spin-valve devices which yields enhanced spin and charge transport properties by improving both the electrode-to-graphene and graphene-to-substrate interface. First, we prepare Co/MgO spin injection electrodes onto Si$^{++}$/SiO$_2$. Thereafter, we mechanically transfer a graphene-hBN heterostructure onto the prepatterned electrodes. We show that room temperature spin transport in single-, bi- and trilayer graphene devices exhibit nanosecond spin lifetimes with spin diffusion lengths reaching 10$\mu$m combined with carrier mobilities exceeding 20,000 cm$^2$/Vs.Comment: 15 pages, 5 figure

Fast and sensitive terahertz detection using an antenna-integrated graphene pn-junction

Although the detection of light at terahertz (THz) frequencies is important for a large range of applications, current detectors typically have several disadvantages in terms of sensitivity, speed, operating temperature, and spectral range. Here, we use graphene as photoactive material to overcome all of these limitations in one device. We introduce a novel detector for terahertz radiation that exploits the photo-thermoelectric effect, based on a design that employs a dual-gated, dipolar antenna with a gap of ~100 nm. This narrow-gap antenna simultaneously creates a pn-junction in a graphene channel located above the antenna, and strongly concentrates the incoming radiation at this pn-junction, where the photoresponse is created. We demonstrate that this novel detector has excellent sensitivity, with a noise-equivalent power of 80 pW/√Hz at room temperature, a response time below 30 ns (setup-limited), a high dynamic range (linear power dependence over more than 3 orders of magnitude) and broadband operation (measured range 1.8 - 4.2 THz, antenna-limited), which fulfils a combination that is currently missing in the state of the art. Importantly, based on the agreement we obtain between experiment, analytical model, and numerical simulations, we have reached a solid understanding of how the PTE eect gives rise to a THz-induced photoresponse, which is very valuable for further detector optimization.Peer ReviewedPostprint (author's final draft

Hot-Carrier Cooling in High-Quality Graphene is Intrinsically Limited by Optical Phonons

Many promising optoelectronic devices, such as broadband photodetectors, nonlinear frequency converters, and building blocks for data communication systems, exploit photoexcited charge carriers in graphene. For these systems, it is essential to understand, and eventually control, the cooling dynamics of the photoinduced hot-carrier distribution. There is, however, still an active debate on the different mechanisms that contribute to hot-carrier cooling. In particular, the intrinsic cooling mechanism that ultimately limits the cooling dynamics remains an open question. Here, we address this question by studying two technologically relevant systems, consisting of high-quality graphene with a mobility >10,000 cm$^2$V$^{-1}$s$^{-1}$ and environments that do not efficiently take up electronic heat from graphene: WSe$_2$-encapsulated graphene and suspended graphene. We study the cooling dynamics of these two high-quality graphene systems using ultrafast pump-probe spectroscopy at room temperature. Cooling via disorder-assisted acoustic phonon scattering and out-of-plane heat transfer to the environment is relatively inefficient in these systems, predicting a cooling time of tens of picoseconds. However, we observe much faster cooling, on a timescale of a few picoseconds. We attribute this to an intrinsic cooling mechanism, where carriers in the hot-carrier distribution with enough kinetic energy emit optical phonons. During phonon emission, the electronic system continuously re-thermalizes, re-creating carriers with enough energy to emit optical phonons. We develop an analytical model that explains the observed dynamics, where cooling is eventually limited by optical-to-acoustic phonon coupling. These fundamental insights into the intrinsic cooling mechanism of hot carriers in graphene will play a key role in guiding the development of graphene-based optoelectronic devices

Ultrafast, Zero-Bias, Graphene Photodetectors with Polymeric Gate Dielectric on Passive Photonic Waveguides.

We report compact, scalable, high-performance, waveguide integrated graphene-based photodetectors (GPDs) for telecom and datacom applications, not affected by dark current. To exploit the photothermoelectric (PTE) effect, our devices rely on a graphene/polymer/graphene stack with static top split gates. The polymeric dielectric, poly(vinyl alcohol) (PVA), allows us to preserve graphene quality and to generate a controllable p-n junction. Both graphene layers are fabricated using aligned single-crystal graphene arrays grown by chemical vapor deposition. The use of PVA yields a low charge inhomogeneity ∼8 × 1010 cm-2 at the charge neutrality point, and a large Seebeck coefficient ∼140 μV K-1, enhancing the PTE effect. Our devices are the fastest GPDs operating with zero dark current, showing a flat frequency response up to 67 GHz without roll-off. This performance is achieved on a passive, low-cost, photonic platform, and does not rely on nanoscale plasmonic structures. This, combined with scalability and ease of integration, makes our GPDs a promising building block for next-generation optical communication devices

Gene Expression Profiling in Gastric Mucosa from Helicobacter pylori-Infected and Uninfected Patients Undergoing Chronic Superficial Gastritis

Helicobacter pylori infection reprograms host gene expression and influences various cellular processes, which have been investigated by cDNA microarray using in vitro culture cells and in vivo gastric biopsies from patients of the Chronic Abdominal Complaint. To further explore the effects of H. pylori infection on host gene expression, we have collected the gastric antral mucosa samples from 6 untreated patients with gastroscopic and pathologic confirmation of chronic superficial gastritis. Among them three patients were infected by H. pylori and the other three patients were not. These samples were analyzed by a microarray chip which contains 14,112 cloned cDNAs, and microarray data were analyzed via BRB ArrayTools software and Ingenuity Pathways Analysis (IPA) website. The results showed 34 genes of 38 differentially expressed genes regulated by H. pylori infection had been annotated. The annotated genes were involved in protein metabolism, inflammatory and immunological reaction, signal transduction, gene transcription, trace element metabolism, and so on. The 82% of these genes (28/34) were categorized in three molecular interaction networks involved in gene expression, cancer progress, antigen presentation and inflammatory response. The expression data of the array hybridization was confirmed by quantitative real-time PCR assays. Taken together, these data indicated that H. pylori infection could alter cellular gene expression processes, escape host defense mechanism, increase inflammatory and immune responses, activate NF-κB and Wnt/β-catenin signaling pathway, disturb metal ion homeostasis, and induce carcinogenesis. All of these might help to explain H. pylori pathogenic mechanism and the gastroduodenal pathogenesis induced by H. pylori infection

Superballistic flow of viscous electron fluid through graphene constrictions

Electron–electron (e–e) collisions can impact transport in a variety of surprising and sometimes counterintuitive ways1,2,3,4,5,6. Despite strong interest, experiments on the subject proved challenging because of the simultaneous presence of different scattering mechanisms that suppress or obscure consequences of e–e scattering7,8,9,10,11. Only recently, sufficiently clean electron systems with transport dominated by e–e collisions have become available, showing behaviour characteristic of highly viscous fluids12,13,14. Here we study electron transport through graphene constrictions and show that their conductance below 150 K increases with increasing temperature, in stark contrast to the metallic character of doped graphene15. Notably, the measured conductance exceeds the maximum conductance possible for free electrons16,17. This anomalous behaviour is attributed to collective movement of interacting electrons, which ‘shields’ individual carriers from momentum loss at sample boundaries18,19. The measurements allow us to identify the conductance contribution arising due to electron viscosity and determine its temperature dependence. Besides fundamental interest, our work shows that viscous effects can facilitate high-mobility transport at elevated temperatures, a potentially useful behaviour for designing graphene-based devices

Emerging Use of Early Health Technology Assessment in Medical Product Development: A Scoping Review of the Literature

Early health technology assessment is increasingly being used to support health economic evidence development during early stages of clinical research. Such early models can be used to inform research and development about the design and management of new medical technologies to mitigate the risks, perceived by industry and the public sector, associated with market access and reimbursement. Over the past 25 years it has been suggested that health economic evaluation in the early stages may benefit the development and diffusion of medical products. Early health technology assessment has been suggested in the context of iterative economic evaluation alongside phase I and II clinical research to inform clinical trial design, market access, and pricing. In addition, performing early health technology assessment was also proposed at an even earlier stage for managing technology portfolios. This scoping review suggests a generally accepted definition of early health technology assessment to be “all methods used to inform industry and other stakeholders about the potential value of new medical products in development, including methods to quantify and manage uncertainty”. The present review also aimed to identify recent published empirical studies employing an early-stage assessment of a medical product. With most included studies carried out to support a market launch, the dominant methodology was early health economic modeling. Further methodological development is required, in particular, by combining systems engineering and health economics to manage uncertainty in medical product portfolios