1,107 research outputs found
Neural Dynamics in Parkinsonian Brain:The Boundary Between Synchronized and Nonsynchronized Dynamics
Synchronous oscillatory dynamics is frequently observed in the human brain.
We analyze the fine temporal structure of phase-locking in a realistic network
model and match it with the experimental data from parkinsonian patients. We
show that the experimentally observed intermittent synchrony can be generated
just by moderately increased coupling strength in the basal ganglia circuits
due to the lack of dopamine. Comparison of the experimental and modeling data
suggest that brain activity in Parkinson's disease resides in the large
boundary region between synchronized and nonsynchronized dynamics. Being on the
edge of synchrony may allow for easy formation of transient neuronal
assemblies
Optimized design of a low-resistance electrical conductor for the multimegahertz range
We propose a design for a conductive wire composed of several mutually insulated coaxial conducting shells. With the help of numerical optimization, it is possible to obtain electrical resistances significantly lower than those of a heavy-gauge copper wire or litz wire in the 2–20 MHz range. Moreover, much of the reduction in resistance can be achieved for just a few shells; in contrast, litz wire would need to contain ∼ 10[superscript 4] strands to perform comparably in this frequency range
Double Neutron Star Systems and Natal Neutron Star Kicks
We study the four double neutron star systems found in the Galactic disk in
terms of the orbital characteristics of their immediate progenitors and the
natal kicks imparted to neutron stars. Analysis of the effect of the second
supernova explosion on the orbital dynamics, combined with recent results from
simulations of rapid accretion onto neutron stars lead us to conclude that the
observed systems could not have been formed had the explosion been symmetric.
Their formation becomes possible if kicks are imparted to the radio-pulsar
companions at birth. We identify the constraints imposed on the immediate
progenitors of the observed double neutron stars and calculate the ranges
within which their binary characteristics (orbital separations and masses of
the exploding stars) are restricted. We also study the dependence of these
limits on the magnitude of the kick velocity and the time elapsed since the
second explosion. For each of the double neutron stars, we derive a minimum
kick magnitude required for their formation, and for the two systems in close
orbits we find it to exceed 200km/s. Lower limits are also set to the
center-of-mass velocities of double neutron stars, and we find them to be
consistent with the current proper motion observations.Comment: 25 pages, 6 figs (9 parts), 4 tables, AASTeX, Accepted in Ap
The Intrinsic Origin of Spin Echoes in Dipolar Solids Generated by Strong Pi Pulses
In spectroscopy, it is conventional to treat pulses much stronger than the
linewidth as delta-functions. In NMR, this assumption leads to the prediction
that pi pulses do not refocus the dipolar coupling. However, NMR spin echo
measurements in dipolar solids defy these conventional expectations when more
than one pi pulse is used. Observed effects include a long tail in the CPMG
echo train for short delays between pi pulses, an even-odd asymmetry in the
echo amplitudes for long delays, an unusual fingerprint pattern for
intermediate delays, and a strong sensitivity to pi-pulse phase. Experiments
that set limits on possible extrinsic causes for the phenomena are reported. We
find that the action of the system's internal Hamiltonian during any real pulse
is sufficient to cause the effects. Exact numerical calculations, combined with
average Hamiltonian theory, identify novel terms that are sensitive to
parameters such as pulse phase, dipolar coupling, and system size.
Visualization of the entire density matrix shows a unique flow of quantum
coherence from non-observable to observable channels when applying repeated pi
pulses.Comment: 24 pages, 27 figures. Revised from helpful referee comments. Added
new Table IV, new paragraphs on pages 3 and 1
The Formation of Low-Mass Transient X-Ray Binaries
We consider constraints on the formation of low-mass X-ray binaries
containing neutron stars (NLMXBs) arising from the presence of soft X-ray
transients among these systems. We show that in short-period systems driven by
angular momentum loss these constraints require the secondary at the beginning
of mass transfer to have a mass > 1.2 M_sun, and to be significantly
nuclear-evolved. As a consequence a comparatively large fraction of such
systems appear as soft X-ray transients even at short periods, as observed.
Moreover the large initial secondary masses account for the rarity of NLMXBs at
periods less than 3 hr. In contrast, NLMXB populations forming with large kick
velocities would not have these properties, suggesting that the kick velocity
is generally small compared to the pre-SN orbital velocity in a large fraction
of systems. We derive constraints on progenitor system parameters and on the
strength of magnetic braking.Comment: Accepted for publication in ApJ, 19 pages, 4 figure
The landscape of gifted and talented education in England and Wales: How are teachers implementing policy?
This is an Author's Accepted Manuscript of an article published in Research Papers in Education, 27(2), 167-186, 2012, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/02671522.2010.509514.This paper explores the evidence relating to how primary schools are responding to the ‘gifted and talented’ initiative in England and Wales. A questionnaire survey which invited both closed and open-ended responses was carried out with a national sample of primary schools. The survey indicated an increasing proportion of coordinators, compared with a survey carried out in 1996, were identifying their gifted and talented children as well as having associated school policies. However, the survey also highlighted a number of issues which need addressing if the initiative is to achieve its objective of providing the best possible educational opportunities for children. For example, it was found that a significant number of practitioners were not aware of the existence of the National Quality Standards for gifted and talented education, provided by the UK government in 2007, and the subject-specific criteria provided by the UK’s Curriculum Authority for identification and provision have been largely ignored. The process of identifying children to be placed on the ‘gifted and talented’ register seems haphazard and based on pragmatic reasons. Analysis of teachers’ responses also revealed a range of views and theoretical positioning held by them, which have implications for classroom practice. As the ‘gifted and talented’ initiative in the UK is entering a second decade, and yet more significant changes in policy are introduced, pertinent questions need to be raised and given consideration
Discovery and analysis of p-mode and g-mode oscillations in the A-type primary of the eccentric binary HD 209295
We have discovered both intermediate-order gravity mode and low-order
pressure mode pulsation in the same star, HD 209295. It is therefore both a
Gamma Doradus and a Delta Scuti star, which makes it the first pulsating star
to be a member of two classes.
The star is a single-lined spectroscopic binary with an orbital period of
3.10575 d and an eccentricity of 0.352. Weak pulsational signals are found in
both the radial velocity and line-profile variations, allowing us to show that
the two highest-amplitude Gamma Doradus pulsation modes are consistent with l=1
and |m|=1.
In our 280 h of BVI multi-site photometry we detected ten frequencies in the
light variations, one in the Delta Scuti regime and nine in the Gamma Doradus
domain. Five of the Gamma Doradus frequencies are exact integer multiples of
the orbital frequency. This observation leads us to suspect they are tidally
excited. Results of theoretical modeling (stability analysis, tidal excitation)
were consistent with the observations.
We could not detect the secondary component of the system in infrared
photometry, suggesting that it may not be a main-sequence star. Archival data
of HD 209295 show a strong ultraviolet excess, the origin of which is not
known. The orbit of the primary is consistent with a secondary mass of M > 1.04
Msun indicative of a neutron star or a white dwarf companion.Comment: 18 pages, 18 figures, accepted for publication in MNRAS, shortened
abstrac
Lysosomes in iron metabolism, ageing and apoptosis
The lysosomal compartment is essential for a variety of cellular functions, including the normal turnover of most long-lived proteins and all organelles. The compartment consists of numerous acidic vesicles (pH ∼4 to 5) that constantly fuse and divide. It receives a large number of hydrolases (∼50) from the trans-Golgi network, and substrates from both the cells’ outside (heterophagy) and inside (autophagy). Many macromolecules contain iron that gives rise to an iron-rich environment in lysosomes that recently have degraded such macromolecules. Iron-rich lysosomes are sensitive to oxidative stress, while ‘resting’ lysosomes, which have not recently participated in autophagic events, are not. The magnitude of oxidative stress determines the degree of lysosomal destabilization and, consequently, whether arrested growth, reparative autophagy, apoptosis, or necrosis will follow. Heterophagy is the first step in the process by which immunocompetent cells modify antigens and produce antibodies, while exocytosis of lysosomal enzymes may promote tumor invasion, angiogenesis, and metastasis. Apart from being an essential turnover process, autophagy is also a mechanism by which cells will be able to sustain temporary starvation and rid themselves of intracellular organisms that have invaded, although some pathogens have evolved mechanisms to prevent their destruction. Mutated lysosomal enzymes are the underlying cause of a number of lysosomal storage diseases involving the accumulation of materials that would be the substrate for the corresponding hydrolases, were they not defective. The normal, low-level diffusion of hydrogen peroxide into iron-rich lysosomes causes the slow formation of lipofuscin in long-lived postmitotic cells, where it occupies a substantial part of the lysosomal compartment at the end of the life span. This seems to result in the diversion of newly produced lysosomal enzymes away from autophagosomes, leading to the accumulation of malfunctioning mitochondria and proteins with consequent cellular dysfunction. If autophagy were a perfect turnover process, postmitotic ageing and several age-related neurodegenerative diseases would, perhaps, not take place
Cognitive and behavioral predictors of light therapy use
Objective: Although light therapy is effective in the treatment of seasonal affective disorder (SAD) and other mood disorders, only 53-79% of individuals with SAD meet remission criteria after light therapy. Perhaps more importantly, only 12-41% of individuals with SAD continue to use the treatment even after a previous winter of successful treatment. Method: Participants completed surveys regarding (1) social, cognitive, and behavioral variables used to evaluate treatment adherence for other health-related issues, expectations and credibility of light therapy, (2) a depression symptoms scale, and (3) self-reported light therapy use. Results: Individuals age 18 or older responded (n = 40), all reporting having been diagnosed with a mood disorder for which light therapy is indicated. Social support and self-efficacy scores were predictive of light therapy use (p's<.05). Conclusion: The findings suggest that testing social support and self-efficacy in a diagnosed patient population may identify factors related to the decision to use light therapy. Treatments that impact social support and self-efficacy may improve treatment response to light therapy in SAD. © 2012 Roecklein et al
Supernova Kicks, Magnetic Braking, and Neutron-Star Binaries
We consider the formation of low-mass X-ray binaries containing accreting
neutron stars via the helium-star supernova channel. The predicted relative
number of short-period transients provides a sensitive test of the input
physics in this process. We investigate the effect of varying mean kick
velocities, orbital angular momentum loss efficiencies, and common envelope
ejection efficiencies on the subpopulation of short-period systems, both
transient and persistent. Guided by the thermal-viscous disk instability model
in irradiation-dominated disks, we posit that short-period transients have
donors close to the end of core-hydrogen burning. We find that with increasing
mean kick velocity the overall short-period fraction, s, grows, while the
fraction, r, of systems with evolved donors among short-period systems drops.
This effect, acting in opposite directions on these two fractions, allows us to
constrain models of LMXB formation through comparison with observational
estimates of s and r. Without fine tuning or extreme assumptions about
evolutionary parameters, consistency between models and current observations is
achieved for a regime of intermediate average kick magnitudes of about 100-200
km/s, provided that (i) orbital braking for systems with donor masses in the
range 1-1.5 solar masses is weak, i.e., much less effective than a simple
extrapolation of standard magnetic braking beyond 1.0 solar mass would suggest,
and (ii) the efficiency of common envelope ejection is low.Comment: 24 pages, AAATeX, accepted for publication in The Astrophysical
Journa
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