SRC-dependent signalling regulates actin ruffle formation induced by glycerophosphoinositol 4-phosphate

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Group IV Phospholipase A2α Controls the Formation of Inter-Cisternal Continuities Involved in Intra-Golgi Transport

The enzyme phospholipase A2 (cPLA2α) is involved in the formation of intercisternal tubules that mediate transport of proteins within the Golgi complex

Intracellular traffic initiates a Golgi-based signalling circuit that co-ordinates the secretory pathway.

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

STM Recommendations for handling image integrity issues

An STM Working Group on Image Alteration and Duplication Detection has been working on best-practice recommendations that outline a structured approach to support editors and others applying image integrity screening as part of pre-publication quality control checks or post-publication investigation of image and data integrity issues at scholarly journals, books, preprint servers, or data repositories. It provides principles and a three-tier classification for different types of image and data aberrations commonly detected in image integrity screens of figures in research papers and for a consideration of impact on the scholarly study; it also recommends actions journal editors may take to protect the scholarly record. With these recommendations, the STM Working Group aims to contribute a consistent, structured and efficient framework for handling image integrity issues both within and between journals and publishers. The framework should support editors in safeguarding research integrity and fortifying the scientific process for the benefit of the scientific community. The recommendations are open for comments until October 31st. The final recommendations, in which we will attempt to process all suggestions and recommendation, will be presented at the STM Innovations Seminar on December 7th. To comment on the document, please register and use the 'comment' icon on the top right of your screen, or send your comments to [email protected]

MEF Promotes Stemness in the Pathogenesis of Gliomas

High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in glioma. We found that MEF is highly expressed in both human and mouse GBMs and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells, has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis by promoting stem cell characteristics through Sox2 activation