Hipotiroidismo congénito: comparativa entre punto de partida y resultados finales

El despistaje del hipotiroidismo congénito se generalizó en España en la década de los 80 del siglo pasado. Basado en la determinación en papel de filtro de TSH, como en el resto de países europeos, llega ahora el momento de evaluar el impacto conseguido sobre la prevención de la subnormalidad. En el presente trabajo se contraponen dos experiencias: la del último año de screening en la Comunidad de Castilla y León con los pacientes hipotiroideos diagnosticados entre 1990-2002, que han alcanzado la madurez incipiente. Se analizan diferentes variables, como la edad del diagnóstico e inicio del tratamiento y se elabora una base de datos que podrá ser ampliada y completada en el futuro.Grado en Medicin

Nesting ecology and floral resource of <i>Xylocopa augusti</i> Lepeletier de Saint Fargeau (Hymenoptera, Apidae) in Argentina

1- A total of 33 nests of Xylocopa augusti was studied during two consecutive seasons. 2- Nesting behaviour and floral resources used by the large carpenter bee X. augusti Lepeletier de Saint Fargeau were studied during the brood production season in an urban area in Argentina. 3- Biological information about nesting aspects inside and outside the nest was considered, paying particular attention to year-long activity, foraging flights throughout the day for nectar and pollen collection, nectar dehydration, oviposition, and pollen preference. 4- In the study area, X. augusti shows an univoltine life cycle, with a peak of nesting between October and December, which coincides with the greatest blooming period of the surrounding flora. 5- From 36 analyzed larval provision samples, 18 pollen types were identified, most of them belonging to ornamental trees or shrubs. Pollen from Eucalyptus Myrceugenia glaucescens (Cambess.) D. Legrand and Kausel (Myrtaceae), Solanum sp.-Cyphomandra betacea (Cav.) Sendtn. (Solanaceae) and Erythrina crista-galli L. (Fabaceae) was dominant. 6- The ability to obtain pollen from poricidal anthers such as those of Solanum indicate the potential of X. augusti to be an excellent managed pollinator and a good candidate for pollinating Solanaceae, such as Solanum lycopersicum ‘tomato’ and Solanum melongena ‘eggplant’, which are economically important crops in this region.Museo de La Plat

Winter distribution of passerine richness in the Maghreb (North Africa): a conservation assessment

This paper studies the factors affecting passerine (Order Passeriformes) species richness in the Western Maghreb, a region at the southwestern border of the Palearctic reputed as a primary wintering ground for many common European birds. The effect of productivity, temperature, landscape structure and geographical location on bird richness was explored at 220 localities across Morocco. The models resulting from multivariate analyses supported the effects of productivity, temperature and landscape cover on bird richness, with higher numbers of species occurring in warm farmlands of the northwest. The most suitable areas for birds avoided the cold and arid expanses of the Atlas Mountains and the Sahara and overlapped with the most human-impacted sectors. Within these areas, we detected an interspersed distribution of sectors of high bird richness and low human incidence. These sectors can be used as priority targets for conservation programmes of common birds during the winter

Co-occurrence of neurofibromatosis type 1 and optic nerve gliomas with autosomal dominant polycystic kidney disease type 2

Background: Autosomal dominant polycystic kidney disease (ADPKD) and neurofibromatosis type 1 (NF1) are both autosomal dominant disorders with a high rate of novel mutations. However, the two disorders have distinct and well-delineated genetic, biochemical, and clinical findings. Only a few cases of coexistence of ADPKD and NF1 in a single individual have been reported, but the possible implications of this association are unknown. Methods: We report an ADPKD male belonging to a family of several affected members in three generations associated with NF1 and optic pathway gliomas. The clinical diagnosis of ADPKD and NF1 was performed by several image techniques. Results: Linkage analysis of ADPKD family was consistent to the PKD2 locus by a nonsense mutation, yielding a truncated polycystin-2 by means of next-generation sequencing. The diagnosis of NF1 was confirmed by mutational analysis of this gene showing a 4-bp deletion, resulting in a truncated neurofibromin, as well. The impact of this association was investigated by analyzing putative genetic interactions and by comparing the evolution of renal size and function in the proband with his older brother with ADPKD without NF1 and with ADPKD cohorts. Conclusion: Despite the presence of both conditions there was not additive effect of NF1 and PKD2 in terms of the severity of tumor development and/or ADPKD progression.This study was financed in part by the Instituto de Salud Carlos III, the Ministerio de Ciencia y Innovación (EC08/00236) and the program for intensifying research activities (IdiPAZ and Agencia Lain Entralgo/CM) to R.P. or the program for intensifying (IdiPAZ and FIBHULP) to J.N. NF1 studies are supported by grants from Fundación Mutua Madrileña de Investigación Biomédica (FMM) and Asociación Española de Afectados de Neurofibromatosis. ISCIII RETIC REDINREN RD16/0009 FEDER Fund

Altered surface expression of insulin-degrading enzyme on monocytes and lymphocytes from COVID-19 patients both at diagnosis and after hospital discharge

Although the COVID-19 disease has developed into a worldwide pandemic, its pathophysiology remains to be fully understood. Insulin-degrading enzyme (IDE), a zinc-metalloprotease with a high affinity for insulin, has been found in the interactomes of multiple SARS-CoV-2 proteins. However, the relevance of IDE in the innate and adaptative immune responses elicited by circulating peripheral blood mononuclear cells is unknown. Here, we show that IDE is highly expressed on the surface of circulating monocytes, T-cells (both CD4+ and CD4−), and, to a lower extent, in B-cells from healthy controls. Notably, IDE’s surface expression was upregulated on monocytes from COVID-19 patients at diagnosis, and it was increased in more severe patients. However, IDE’s surface expression was downregulated (relative to healthy controls) 3 months after hospital discharge in all the studied immune subsets, with this effect being more pronounced in males than in females, and thus it was sex-dependent. Additionally, IDE levels in monocytes, CD4+ T-cells, and CD4− T-cells were inversely correlated with circulating insulin levels in COVID-19 patients (both at diagnosis and after hospital discharge). Of note, high glucose and insulin levels downregulated IDE surface expression by ~30% in the monocytes isolated from healthy donors, without affecting its expression in CD4+ T-cells and CD4− T-cells. In conclusion, our studies reveal the sex- and metabolism-dependent regulation of IDE in monocytes, suggesting that its regulation might be important for the recruitment of immune cells to the site of infection, as well as for glucometabolic control, in COVID-19 patients.This work was funded by the European Commission–NextGenerationEU (Regulation EU 2020/2094), through CSIC’s Global Health Platform (PTI Salud Global) and Junta de Castilla y León (Proyectos COVID 07.04.467B04.74011.0) to D.B. The project leading to these results had received funding from the “La Caixa” Foundation under agreement LCF/PR/PR18/51130007 to G.P. and grant PID2019-110496RB-C22 funded by MCIN/AEI/10.13039/501100011033 to G.P. This research was funded by the Programa Estratégico Instituto de Biología y Genética Molecular (IBGM), Junta de León and the European Social Fund (ORDER EDU/574/2018)

Determinación de la calidad de sitio y productividad de los bosques de Palo Santo en el norte de Argentina = Determination of site quality and productivity of Palo Santo forests in northern Argentina

El objetivo general del trabajo fue aportar información sobre la productividad y calidad de sitio para los bosques de Palo Santo en su área de distribución en Argentina, a fin de establecer lineamientos unificadores de manejo y uso para su aprovechamiento sostenible. Se utilizó información de 482 parcelas de inventarios forestales nacionales, regionales y locales de diferentes años en el norte de Argentina, que provienen de muestreos realizados en bosques nativos en tenencias de comunidades aborígenes, campesinas y planes de manejo. Se utilizó el área basal, volumen de fuste y altura dominante de Palo Santo de cada una de las parcelas para determinar clases de calidad de sitio y mediante una clasificación de un mosaico de imágenes satelitales Landsat del año 2019 con sus bandas originales y diferentes índices, fracciones, pendientes y proxys relacionados a la estructura de la vegetación. A partir de los datos, se calculó la duración del ciclo de corta y la intensidad de corta sostenible para los bosques de Palo Santo según su calidad de sitio. Los resultados permiten asumir que las existencias de Palo Santo son suficientes para continuar con su aprovechamiento sostenible sin comprometer su persistencia. La información generada es de utilidad para los tomadores de decisión, reflejando, además, el potencial forestal de la especie su aporte a las economías regionales y al desarrollo de los entramados productivos provinciales.The general objective of this study was to provide information regarding the productivity and site quality of Palo Santo forests in their Argentinean distribution area in order to establish guidelines for sustainable management and use. We used data taken from 482 plots as part of national, regional and local forest inventories in northern Argentina, carried out in native forests within aboriginal and peasant community tenures and management plans. Basal area, stem volume and dominant height of Palo Santo trees were used to determine site quality class. This was correlated to forest structure by using a classification mosaic from Landsat satellite images. A sustainable cutting cycle duration and harvest intensity for Palo Santo forests were calculated according to their site quality. The results suggest that the current stocks of Palo Santo are sufficient to continue with its sustainable use without compromising its longterm availability. This information is useful for decision makers and defines the potential of the species to provide resources to regional economies and provincial productive development.EEA Sáenz PeñaFil: Kees, Sebastian Miguel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Sáenz Peña. Campo Anexo Estación Forestal Plaza; Argentina.Fil: Loto, Dante. Universidad Nacional de Santiago del Estero. Instituto de Silvicultura y Manejo de Bosques; Argentina.Fil: Loto, Dante. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Azcona, Maximiliano. Ministerio de Ambiente y Desarrollo Sustentable de la Nación. Dirección Nacional de Bosques. Autoridad Científica CITES en especies forestales; Argentina.Fil: De Tellería, Santiago. Ministerio de Ambiente y Desarrollo Sustentable de la Nación. Dirección Nacional de Bosques. Autoridad Científica CITES en especies forestales; Argentina.Fil: Manghi, Eduardo. Ministerio de Ambiente y Desarrollo Sustentable de Nación. Dirección de Bosques. Secretaría de Política Ambiental en Recursos Naturales; Argentina.Fil: Gaitan, Juan José. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de investigación de Suelos; Argentina.Fil: Chifarelli, Vanina. Universidad Nacional de Santiago del Estero. Facultad de Ciencias Forestales; Argentina.Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina.Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina.Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Estructura vertical de bosques de Gonopterodendron sarmientoi en Argentina

Se ajustaron funciones preliminares y regionales de altura media por clase diamétrica de palo santo (Gonopterodendron sarmientoi) para ser utilizadas en el Parque Chaqueño. Las funciones obtenidas predicen la altura total media por clase diamétrica para diferentes tipos de bosques de palo santo. Se trabajó sobre datos de 482 parcelas con presencia de la especie, provenientes de inventarios forestales en bosques nativos en tenencias de comunidades aborígenes, campesinas y planes de manejo cubriendo parte de las provincias de Salta, Formosa y Chaco. Con los datos de la parcela se aplicó el método del diagrama h (altura total de los árboles) – M (valor acumulativo medio de las alturas) para describir la estructura vertical. Los modelos ajustados fueron satisfactorios para el conjunto de datos en general y también para todos los grupos. Respecto a la estructura vertical, palo santo está presente en todos los estratos para los grupos palosantal, y de alta presencia de palo santo, mientras que, en el grupo bosques con baja presencia de palo santo se evidenció una falta de ejemplares en los estratos bajos e intermedios.EEA Saenz PeñaFil: Kees, Sebastian Miguel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Sáenz Peña. Campo Anexo Estación Forestal Plaza. Chaco; Argentina.Fil: Loto, Dante. Universidad Nacional de Santiago del Estero; Argentina.Fil: Loto, Dante. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Azcona, Maximiliano. Ministerio de Ambiente y Desarrollo Sustentable de la Nación. Dirección Nacional de Bosques. Autoridad Científica CITES en especies forestales; Argentina.Fil: De Tellería, Santiago. Ministerio de Ambiente y Desarrollo Sustentable de la Nación. Dirección Nacional de Bosques. Autoridad Científica CITES en especies forestales; Argentina.Fil: Manghi, Eduardo. Ministerio de Ambiente y Desarrollo Sustentable de Nación. Dirección de Bosques. Secretaría de Política Ambiental en Recursos Naturales; Argentina.Fil: Gaitan, Juan José. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de investigación de Suelos; Argentina.Fil: Chifarelli, Vanina. Universidad Nacional de Santiago del Estero. Facultad de Ciencias Forestales; Argentina.Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina.Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina.Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Cochera libre app

El modelo de negocio Cochera Libre App está enfocado en brindar un servicio de búsqueda fácil y seguro de estacionamientos en los diferentes puntos estratégicos de Lima Metropolitana y Callao a través de un aplicativo móvil. Para ello, se está considerando como propuesta diferenciadora incluir motos, autos, bicicletas y scooters, con el objetivo de captar nuevos clientes y posicionarnos en el mercado. Además, los precios están orientados en tarifas dinámicas según la ubicación del usuario y los estacionamientos disponibles. Al elaborar las entrevistas a profundidad se identificó que hay una necesidad para implementar este proyecto en el mercado peruano enfocados a varones y mujeres de 25 a 55 años del NSE A, B y C. Para SMIA - Sistema Metropolitano de Información Ambiental (2020) la pandemia del COVID-19 ha generado que las personas utilicen como alternativa otros tipos de vehículos generando nuevos hábitos que mejoren una movilidad sostenible.The Parking Free App business model is focused on providing an easy and safe parking search service at the different strategic points of Metropolitan Lima and Callao through a mobile application. For this, it is being considered as a differentiating proposal to include motorcycles, cars, bicycles or scooters, with the aim of attracting new customers and positioning ourselves in the market. In addition, the prices are based on dynamic rates based on the user's location and available parking spaces. When preparing the in-depth interviews, it was identified that there is a need to implement this project in the Peruvian market focused on men and women between the ages of 25 and 55 from NSE A, B and C. For SMIA - Sistema Metropolitano de Información Ambiental (2020) the COVID-19 pandemic It has led people to use other types of vehicles as an alternative, discovering new habits that improve sustainable mobility.Trabajo de investigació

Predicting Clinical Outcome with Phenotypic Clusters in COVID-19 Pneumonia: An Analysis of 12,066 Hospitalized Patients from the Spanish Registry SEMI-COVID-19

(1) Background: Different clinical presentations in COVID-19 are described to date, from mild to severe cases. This study aims to identify different clinical phenotypes in COVID-19 pneumonia using cluster analysis and to assess the prognostic impact among identified clusters in such patients. (2) Methods: Cluster analysis including 11 phenotypic variables was performed in a large cohort of 12,066 COVID-19 patients, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish Society of Internal Medicine (SEMI)-COVID-19 Registry. (3) Results: Of the total of 12,066 patients included in the study, most were males (7052, 58.5%) and Caucasian (10,635, 89.5%), with a mean age at diagnosis of 67 years (standard deviation (SD) 16). The main pre-admission comorbidities were arterial hypertension (6030, 50%), hyperlipidemia (4741, 39.4%) and diabetes mellitus (2309, 19.2%). The average number of days from COVID-19 symptom onset to hospital admission was 6.7 (SD 7). The triad of fever, cough, and dyspnea was present almost uniformly in all 4 clinical phenotypes identified by clustering. Cluster C1 (8737 patients, 72.4%) was the largest, and comprised patients with the triad alone. Cluster C2 (1196 patients, 9.9%) also presented with ageusia and anosmia; cluster C3 (880 patients, 7.3%) also had arthromyalgia, headache, and sore throat; and cluster C4 (1253 patients, 10.4%) also manifested with diarrhea, vomiting, and abdominal pain. Compared to each other, cluster C1 presented the highest in-hospital mortality (24.1% vs. 4.3% vs. 14.7% vs. 18.6%; p 20 bpm, lower PaO2/FiO2 at admission, higher levels of C-reactive protein (CRP) and lactate dehydrogenase (LDH), and the phenotypic cluster as independent factors for in-hospital death. (4) Conclusions: The present study identified 4 phenotypic clusters in patients with COVID-19 pneumonia, which predicted the in-hospital prognosis of clinical outcomes

Rationale and design of the Concordance study between FFR and iFR for the assessment of lesions in the left main coronary artery. The ILITRO-EPIC-07 Trial

Introduction and objectives: Patients with left main coronary artery (LMCA) stenosis have been excluded from the trials that support the non-inferiority of the instantaneous wave-free ratio (iFR) compared to the fractional flow reserve (FFR) in the decision-making process of coronary revascularization. This study proposes to prospectively assess the concordance between the two indices in LMCA lesions and to validate the iFR cut-off value of 0.89 for clinical use. Methods: National, prospective, and observational multicenter registry of 300 consecutive patients with intermediate lesions in the LMCA (angiographic stenosis, 25% to 60%. A pressure gudiewire study and determination of the RFF and the iFR will be performed: in the event of a negative concordant result (FFR > 0.80/iFR > 0.89), no treatment will be performed; in case of a positive concordant result (FFR 0.80/iFR 0.89), an intravascular echocardiography will be performed and revascularization will be delayed if the minimum lumen area is > 6 mm(2). The primary clinical endpoint will be a composite of cardiovascular death, LMCA lesion-related non-fatal infarction or need for revascularization of the LMCA lesion at 12 months. Conclusions: Confirm that an iFR-guided decision-making process in patients with intermediate LMCA stenosis is clinically safe and would have a significant clinical impact. Also, justify its systematic use when prescribing treatment in these potentially high-risk patients