Mundos autónomos y la transgresión en los relatos de Marina Perezagua

Marina Perezagua’s short stories have a destabilizing character closely related to fantasy literature; however, the supernatural elements present in her work are not used in accordance with the provisions of that genre. We propose a study of the original vision of Marina Perezagua, observing possible similarities and differences in relation to the fantastic. Our analysis will be centered on the characteristics of the autonomous worlds that are constructed in conflict with what is established, and in the different aspects of transgression, highlighting the importance of the literalness that allows old topics to take an unexpected turn.La narrativa breve de Marina Perezagua tiene un carácter desestabilizador cercano al de la literatura fantástica;  sin embargo, los elementos sobrenaturales, presentes en su obra, no se emplean de acuerdo con los preceptos de este género. Nos proponemos estudiar el enfoque original de Marina Perezagua, observando posibles similitudes y diferencias respecto a lo fantástico. Nuestro análisis se centrará en las características de los mundos autónomos, que se construyen en conflicto con lo establecido, y en diferentes aspectos de la transgresión, destacando la importancia de la literalidad que permite dar un giro inesperado a los antiguos tópicos

Ovulatory Response of Weaned Sows to an Altered Ratio of Exogenous Gonadotrophins

[EN] At weaning, 33 mixed parity Hypor sows received either an injection of 400 IU equine chorionic gonadotrophin and 200 IU human chorionic gonadotrophin (hCG) (PG600; n = 13), PG600 with an additional 200 IU hCG 24 h later (Gn800; n = 11), or served as non-injected controls (n = 9). All gonadotrophin treated sows received an injection of 750 IU hCG at 80 h after weaning to induce ovulation (designated as time 0 h). At 0, 24, 36, 40, 44, 48, and 60 h, all sows were subject to transrectal ultrasonography to determine numbers and sizes of large (>6 mm) follicles and time of ovulation. The interval from injection of 750 IU hCG to ovulation was shorter in Gn800 compared to PG600 sows (p = 0.02), and more Gn800 sows had ≥9 preovulatory follicles compared to PG600 and controls (p = 0.02 and 0.003, respectively). Follicular cysts were evident in both PG600 and Gn800 sows.SIThis work was supported by California State University Agriculture Research Institute (Grants 58982 and 58909), and CalPoly internal funding programs Baker/Koob and RSCA.We gratefully acknowledge Merck Animal Health, for financial support and the provision of PG600 and Chorulon

The Suinfort® Semen Supplement Counters Seasonal Infertility in Iberian Sows

[EN] Suinfort®, a commercial semen supplement demonstrated to increase fertility and litter size in commercial sows, was tested to improve reproductive performance in Iberian sows. A total of 1430 Iberian sows were artificially inseminated (AI) with semen from Duroc boars and assigned by parity to receive the seminal additive Suinfort® containing 2 IU oxytocin, 5 µg lecirelin, and 2 mM caffeine (SF; n = 1713 AI), or to serve as non-supplemented controls (CON; n = 2625 AI). CON showed a lower fertility comparing to winter for spring (p = 0.001) and summer (p 0.05). Fertility was significantly higher for SF sows during summer (p = 0.025) and autumn (p = 0.004). Total born, live-born, stillborn, and mummified piglets did not differ between CON and SF but were impacted by the season, with total and live-born decreasing in summer compared with autumn (p < 0.001) and winter (p = 0.005). In conclusion, seminal supplementation with Suinfort® improved the fertility of Iberian sows during periods of seasonal infertilitySIThis research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector

Effect of Season and Parity on Reproduction Performance of Iberian Sows Bred with Duroc Semen

[EN] The Iberian pig is an autochthonous breed from the Iberian Peninsula highly valued for its meat. The sows are often bred as Iberian × Duroc crossings for increased efficiency. Since sow parity and season affect the reproductive performance, we evaluated two-year records from a commercial farrow-to-finish farm (live, stillborn, and mummified piglets after artificial insemination, AI). A total of 1293 Iberian sows were inseminated with semen from 57 boars (3024 AI). The effects of parity (gilts, 1, 2–4, 5–10, and >10 farrowings) and season were analyzed by linear mixed-effects models (LME). The data were fitted to cosinor models to investigate seasonal effects within parity groups. The effects of maximum daily temperature (MDT) and day length change (DLC) during spermatogenesis, pre-AI, and post-AI periods were analyzed with LME. The 2–4 group was the optimal one for parity. A seasonal effect was evident between spring–summer (lower fertility/prolificacy) and autumn–winter (higher). Cosinor showed that the seasonal drop in reproductive performance occurs earlier in Iberian sows than in other breeds, more evident in gilts. MDT negatively affected performance in all periods and DLC in spermatogenesis and pre-AI. These results are relevant for the improvement of Iberian sows’ intensive farmingSIF. Martínez-Pastor participated in the PIVEV network (AGL2016-81890-REDT, MINECO). This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector

„Lustrzane” relacje między Hiszpanią i H ispanoameryką w dwóch powieściach José María Merino - El caldero de oro i La orilla oscura

Tanto El caldero de oro (1981) como La orilla oscura (1985) tratan de unas curiosas relaciones especulares entre España e Hispanoamérica −entre españoles e hispanoamericanos−, tema recurrente e importante en la narrativa de José María Merino a partir de su particular descubrimiento de América. En el presente artículo nos proponemos estudiar los diferentes aspectos de esta estrecha relación, analizando la confluencia de las tradiciones de las dos orillas – en lo que se refiere al mestizaje y a los referentes literarios−, así como el motivo del doble vinculado a los problemas de identidad que experimentan los protagonistas. En el planteamiento de Merino observamos tanto algunos rasgos propios de la literatura fantástica como, también, una propuesta innovadora frente a la tradición de este género.Merino’s novels El caldero de oro (1981) and La orilla oscura (1985) present the “mirror” relations between Spain and Spanish America, between the Spanish and the Spanish Americans, a recurring and important theme in José María Merino’s narrative since his personal discovery of America. This article aims to study the various aspects of that close relationship, taking into account the convergence of literary traditions as well as the doppelganger motif linked to the crisis of identity that the protagonists suffer. The author argues that Merino’s novels are a perfect blend of typical features of fantasy literature and some new artistic devices.W powieści El caldero de oro (1981) i La orilla oscura (1985) przedstawiono szczególne, „lustrzane” relacje między Hiszpanią a Hispanoameryką, między Hiszpanami a Hispanoamerykanami. Od czasu, kiedy Merino doświadczył swojego osobistego odkrycia Ameryki, temat ten zajmuje istotne miejsce w jego twórczości. W artykule dokonano przeglądu różnych aspektów wspomnianych „lustrzanych relacji”, uwzględniając związki krwi, wspólne elementy tradycji literackiej oraz motyw Doppelgänger związany z poczuciem tożsamości. Postawiono tezę, że Merino, wykorzystując środki i motywy typowe dla fantastyki, proponuje zarazem rozwiązania nowatorskie względem tradycji tego gatunku

Draft Genome Sequence of Gordonia sp. Strain Campus, a Bacterium Isolated from Diesel-Contaminated Soil with Potential Use in Phytoremediation Systems

We present the draft genome sequence of Gordonia sp. strain Campus, which was extracted from diesel-contaminated soil in Córdoba, Argentina. It was observed that this strain, in conjunction with alfalfa and poplar, has the ability to decompose diesel-contaminated soils. The data may be important for the phytoremediation of hydrocarbon-contaminated soils.Fil: Badariotti, Esteban H. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Beyrne, Eduardo. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Tejerina, Magdalena. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Unidad Asociada al CONICET: Área de Ciencias Agrarias, Ingeniería, Ciencias Biológicas; ArgentinaFil: Raymond, María L. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Unidad Asociada al CONICET: Área de Ciencias Agrarias, Ingeniería, Ciencias Biológicas; ArgentinaFil: Soria, Néstor W. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Unidad Asociada al CONICET: Área de Ciencias Agrarias, Ingeniería, Ciencias Biológicas; Argentin

Ovulatory response of weaned sows to an altered ratio of exogenous gonadotrophins

At weaning, 33 mixed parity Hypor sows received either an injection of 400 IU equine chorionic gonadotrophin and 200 IU human chorionic gonadotrophin (hCG) (PG600; n = 13), PG600 with an additional 200 IU hCG 24 h later (Gn800; n = 11), or served as non‐injected controls (n = 9). All gonadotrophin treated sows received an injection of 750 IU hCG at 80 h after weaning to induce ovulation (designated as time 0 h). At 0, 24, 36, 40, 44, 48, and 60 h, all sows were subject to transrectal ultrasonography to determine numbers and sizes of large (>6 mm) follicles and time of ovulation. The interval from injection of 750 IU hCG to ovulation was shorter in Gn800 compared to PG600 sows (p = 0.02), and more Gn800 sows had ≥9 preovulatory follicles compared to PG600 and controls (p = 0.02 and 0.003, respectively). Follicular cysts were evident in both PG600 and Gn800 sows.</p

Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder leading to muscle weakness and respiratory failure. Arimoclomol, a heat-shock protein-70 (HSP70) co-inducer, is neuroprotective in animal models of amyotrophic lateral sclerosis, with multiple mechanisms of action, including clearance of protein aggregates, a pathological hallmark of sporadic and familial amyotrophic lateral sclerosis. We aimed to evaluate the safety and efficacy of arimoclomol in patients with amyotrophic lateral sclerosis. ORARIALS-01 was a multinational, randomised, double-blind, placebo-controlled, parallel-group trial done at 29 centres in 12 countries in Europe and North America. Patients were eligible if they were aged 18 years or older and met El Escorial criteria for clinically possible, probable, probable laboratory-supported, definite, or familial amyotrophic lateral sclerosis; had an ALS Functional Rating Scale-Revised score of 35 or more; and had slow vital capacity at 70% or more of the value predicted on the basis of the participant's age, height, and sex. Patients were randomly assigned (2:1) in blocks of 6, stratified by use of a stable dose of riluzole or no riluzole use, to receive oral arimoclomol citrate 1200 mg/day (400 mg three times per day) or placebo. The Randomisation sequence was computer generated centrally. Investigators, study personnel, and study participants were masked to treatment allocation. The primary outcome was the Combined Assessment of Function and Survival (CAFS) rank score over 76 weeks of treatment. The primary outcome and safety were analysed in the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, NCT03491462, and is completed. Between July 31, 2018, and July 17, 2019, 287 patients were screened, 245 of whom were enrolled in the trial and randomly assigned. The modified intention-to-treat population comprised 239 patients (160 in the arimoclomol group and 79 in the placebo group): 151 (63%) were male and 88 (37%) were female; mean age was 57·6 years (SD 10·9). CAFS score over 76 weeks did not differ between groups (mean 0·51 [SD 0·29] in the arimoclomol group vs 0·49 [0·28] in the placebo group; p=0·62). Cliff's delta comparing the two groups was 0·039 (95% CI –0·116 to 0·194). Proportions of participants who died were similar between the treatment groups: 29 (18%) of 160 patients in the arimoclomol group and 18 (23%) of 79 patients in the placebo group. Most deaths were due to disease progression. The most common adverse events were gastrointestinal. Adverse events were more often deemed treatment-related in the arimoclomol group (104 [65%]) than in the placebo group (41 [52%]) and more often led to treatment discontinuation in the arimoclomol group (26 [16%]) than in the placebo group (four [5%]). Arimoclomol did not improve efficacy outcomes compared with placebo. Although available biomarker data are insufficient to preclude future strategies that target the HSP response, safety data suggest that a higher dose of arimoclomol would not have been tolerated. Orphazyme