A Circular Economy of Electrochemical Energy Storage Systems: Critical Review of SOH/RUL Estimation Methods for Second-Life Batteries

Humanity is facing a gloomy scenario due to global warming, which is increasing at unprecedented rates. Energy generation with renewable sources and electric mobility (EM) are considered two of the main strategies to cut down emissions of greenhouse gasses. These paradigm shifts will only be possible with efficient energy storage systems such as Li-ion batteries (LIBs). However, among other factors, some raw materials used on LIB production, such as cobalt and lithium, have geopolitical and environmental issues. Thus, in a context of a circular economy, the reuse of LIBs from EM for other applications (i.e., second-life batteries, SLBs) could be a way to overcome this problem, considering that they reach their end of life (EoL) when they get to a state of health (SOH) of 70–80% and still have energy storage capabilities that could last several years. The aim of this chapter is to make a review of the estimation methods employed in the diagnosis of LIB, such as SOH and remaining useful life (RUL). The correct characterization of these variables is crucial for the reassembly of SLBs and to extend the LIBs operational lifetime

A Plea for Risk

Mountaineering is a dangerous activity. For many mountaineers, part of its very attraction is the risk, the thrill of danger. Yet mountaineers are often regarded as reckless or even irresponsible for risking their lives. In this paper, we offer a defence of risk-taking in mountaineering. Our discussion is organised around the fact that mountaineers and non-mountaineers often disagree about how risky mountaineering really is. We hope to cast some light on the nature of this disagreement – and to argue that mountaineering may actually be worthwhile because of the risks it involves. Section 1 introduces the disagreement and, in doing so, separates out several different notions of risk. Sections 2–4 then consider some explanations of the disagreement, showing how a variety of phenomena can skew people’s risk judgements. Section 5 then surveys some recent statistics, to see whether these illuminate how risky mountaineering is. In light of these considerations, however, we suggest that the disagreement is best framed not simply in terms of how risky mountaineering is but whether the risks it does involve are justified. The remainder of the paper, sections 6–9, argues that risk-taking in mountaineering often is justified – and, moreover, that mountaineering can itself be justified (in part) by and because of the risks it involves

Integrating and sharing accession-level and omics-size genotype, phenotype and environmental data: Experiences at the International Potato Center (CIP).

Plant breeding consists in the creation and selection of new genotypes. This involves not only keeping records across generations and environments but also accommodating data of increasing resolution on genotypes, phenotypes, and growth environments. Some such high-resolution characterization methods are Near-Infrared spectroscopy, metabolomics, next-generation sequencing and high resolution spatial-temporal-spectral photos. A first need is the integration and retrieval of this information. Such an integrated and complete set can be described in breeder’s terms in six dimensions: a plant phenotype (P) is the result of a genotypes (G) interaction with its environment (E) given certain field management (M) practices. In addition, data on the administrative (A) context should be kept including staff involved, objectives and, if applicable, projects and donors; as well as on data documentation standards (S) like ontologies. The latter play an important part in exchanging and aggregating information. Here we describe the adoption of the ‘Biomart’ database for this purpose. While Biomart was developed originally to accommodate gene and sequencing data at a genomic scale we describe here how it can be used for breeding program data. This is being illustrated by current data warehousing in the potato breeding program at the International Potato Center (CIP). Particularly, genotype and phenotype can be transparently combined for further analysis in the decision process for the selection of new genotypes

Prioritizing Residents\u27 Needs: On the Creation of a Residents as Teachers and Leaders Program

Introduction: Residents are responsible for the majority of medical student teaching and directly supervise, instruct, and evaluate students. Many organizations now recommend that residency training programs include venues specifically designed to develop resident teaching skills. [See PDF for abstract]

Quantitative ultrasound spectroscopy for screening cylindrical lithium-ion batteries for second-life applications

Diagnosing lithium-ion battery degradation is a crucial part of managing energy storage systems. Recent research has explored ultrasonic testing for non-invasive health assessment as an alternative to traditional, time-consuming, electrical-only methods. Assessing the state of health is vital for determining quality at end of ‘first’ life, with retired batteries at 70–80 % health still holding value for secondlife applications. Over the coming years, tens of GWh of salvaged batteries will hit the market, requiring rapid noninvasive methods to classify retired batteries according to their state of health. This study uses a 64 – element ultrasonic array to obtain mid-band quantitative ultrasound spectroscopy parameters – including mid-band fit, spectral slope, and intercept – from circumferential waves around cylindrical batteries. Thirteen cylindrical cells were used to evaluate the methodology: three pristine and ten retired from the same source. The mid-band fit showed the ability to track the state of charge and discriminate between the state of health levels in accelerated degradation experiments both with pristine batteries, and also with recovered secondlife batteries with unknown historical use. Linear-array ultrasonic transducers, coupled with quantitative spectral parameters, show promise for future non-destructive battery health screening methods, offering valuable insights for the emerging used battery market

Effect Of Gender On T-Cell Proliferative Responses To Myelin Proteolipid Protein Antigens In Patients With Multiple Sclerosis And Controls

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. Gender influences both susceptibility to MS, with the disease being more common in women, and the clinical course of disease, with an increased proportion of males developing the primary progressive form of the disease. The basis for these differences may include genetic and immunological factors, and the immunological differences between men and women may be influenced by the effects of the sex hormones. Over several years we have collected blood from MS patients and controls, and measured T-cell responses to myelin proteolipid protein (PLP) and myelin basic protein (MBP) and have shown increased responses to PLP in MS patients compared to healthy controls and patients with other neurological diseases. In the present study we analyzed data from over 500 individuals, to determine whether there are differences between males and females in their responses to PLP and MBP. We found that there was higher frequency of increased T-cell reactivity to immunodominant PLP peptides in women than in men, particularly in non-MS individuals. We suggest that this may be relevant to the higher prevalence of MS in women

A Heritage Science Workflow to Preserve and Narrate a Rural Archeological Landscape Using Virtual Reality: The Cerro del Castillo of Belmez and Its Surrounding Environment (Cordoba, Spain)

The main aim of this article is to present a heritage action protocol based on the application of photogrammetric and LiDAR acquisitions, a catalogue of flora and fauna, archeological research, and 3D virtualization for the integrated recovery of a rural cultural heritage site located in the Alto Guadiato Valley of Cordoba, Spain. This joint multidisciplinary action focusing on a common heritage objective has resulted in a comprehensive and innovative action: the virtualization of an 800-hectare multitemporal archeological landscape. The results may be of interest to researchers, educators, and tourism agents, or for the dissemination of scientific knowledge, among other applications. The protocol of actions implemented in the framework of this project can be replicated in sites with similar characteristics, particularly rural areas with well-preserved landscapes that have not been investigated. The main result of the project is the preservation of geomorphological features using remote sensing technologies and the creation of a virtual lookout for this historical and natural landscape (GuadiatVR), which is a very uncommon outcome within the virtualization of historical landscapes. The lookout can be downloaded from Google Play on IOS

Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human single-nucleotide polymorphism studies, together with mouse genetic modeling, have demonstrated that decreased GCH1 leads to both reduced BH4 and pain. However, little is known about the regulation of Gch1 expression upon nerve injury and whether this could be modulated as an analgesic therapeutic intervention. We performed a phenotypic screen using about 1000 bioactive compounds, many of which are target-annotated FDA-approved drugs, for their effect on regulating Gch1 expression in rodent injured dorsal root ganglion neurons. From this approach, we uncovered relevant pathways that regulate Gch1 expression in sensory neurons. We report that EGFR/KRAS signaling triggers increased Gch1 expression and contributes to neuropathic pain; conversely, inhibiting EGFR suppressed GCH1 and BH4 and exerted analgesic effects, suggesting a molecular link between EGFR/KRAS and pain perception. We also show that GCH1/BH4 acts downstream of KRAS to drive lung cancer, identifying a potentially druggable pathway. Our screen shows that pharmacologic modulation of GCH1 expression and BH4 could be used to develop pharmacological treatments to alleviate pain and identified a critical role for EGFR-regulated GCH1/BH4 expression in neuropathic pain and cancer in rodents