Elicitation and representation of expert knowledge for computer aided diagnosis in mammography

To study how professional radiologists describe, interpret and make decisions about micro-calcifications in mammograms. The purpose was to develop a model of the radiologists' decision making for use in CADMIUM II, a computerized aid for mammogram interpretation that combines symbolic reasoning with image processing

Variability and polarization in the inner jet of 3C395

We present new results on the parsec-scale jet of the quasar 3C395, derived from VLBI polarization sensitive observations made in 1995.91 and 1998.50 at 8.4, 15.4 and 22.2 GHz. The observations show a complex one-sided jet extending up to 20 mas, with a projected magnetic field essentially aligned with the radio jet. The emission is strongly dominated, in total intensity and polarization, by the core and the inner jet region (of ~3 mas length). We have studied the details of this dominant region finding clear structural variations during this ~2.5 years period, in contrast with the apparent quietness of the jet structure inferred from lower resolution VLBI observations. We observe the ejection of a new component from the core and variations in the degree of polarization of the inner jet components. We estimate a high Faraday Rotation Measure close to the core, with a strong decrease along the inner jet.Comment: 7 pages, 4 figures, A&A in pres

CAD in mammography: lesion-level versus case-level analysis of the effects of prompts on human decisions

Object: To understand decision processes in CAD-supported breast screening by analysing how prompts affect readers’ judgements of individual mammographic features (lesions). To this end we analysed hitherto unexamined details of reports completed by mammogram readers in an earlier evaluation of a CAD tool. Material and methods: Assessments of lesions were extracted from 5,839 reports for 59 cancer cases. Statistical analyses of these data focused on what features readers considered when recalling a cancer case and how readers reacted to CAD prompts. Results: About 13.5% of recall decisions were found to be caused by responses to features other than those indicating actual cancer. Effects of CAD: lesions were more likely to be examined if prompted; the presence of a prompt on a cancer increased the probability of both detection and recall especially for less accurate readers in subtler cases; lack of prompts made cancer features less likely to be detected; false prompts made non-cancer features more likely to be classified as cancer. Conclusion: The apparent lack of impact reported for CAD in some studies is plausibly due to CAD systematically affecting readers’ identification of individual features, in a beneficial way for certain combinations of readers and features and a damaging way for others. Mammogram readers do not ignore prompts. Methodologically, assessing CAD by numbers of recalled cancer cases may be misleading

Changes in the trajectory of the radio jet in 0735+178?

We present multi-epoch 8.4 and 43 GHz Very Long Baseline Array images of the BL Lac object 0735+178. The images confirm the presence of a twisted jet with two sharp apparent bends of 90$^{\circ}$ within two milliarcseconds of the core, resembling a helix in projection. The observed twisted geometry could be the result of precession of the jet inlet, but is more likely produced by pressure gradients in the external medium through which the jet propagates. Quasi-stationary components are observed at the locations of the 90$^{\circ}$ bends, possibly produced by differential Doppler boosting. Identification of components across epochs, since the earliest VLBI observations of this source in 1979.2, proves difficult due to the sometimes large time gaps between observations. One possible identification suggests the existence of superluminal components following non--ballistic trajectories with velocities up to $11.6\pm 0.6 h_{65}^{-1} c$. However, in images obtained after mid-1995, components show a remarkable tendency to cluster near several jet positions, suggesting a different scenario in which components have remained nearly stationary in time at least since mid-1995. Comparison with the earlier published data, covering more than 19 years of observations, suggests a striking qualitative change in the jet trajectory sometime between mid-1992 and mid-1995, with the twisted jet structure with stationary components becoming apparent only at the later epochs. This would require a re-evaluation of the physical parameters estimated for 0735+178, such as the observing viewing angle, the plasma bulk Lorentz factor, and those deduced from these.Comment: 18 pages, 5 figures, accepted for publication in MNRA

Therapeutic management of the odontogenic keratocyst. An energetic approach with a conservative perspective and review of the current therapeutic options

Background: Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination. Material and methods: This study reports a 12-year-old girl that presented an asymptomatic large radiolucent unilocular lesion associated to the crown of 3.8 that caused displacement of the molar and the inferior alveolar canal. Differential diagnosis included OKC, unicystic ameloblastoma, ameloblastic fibroma, dentigerous cyst and orthokeratinized odontogenic cyst. Two surgical interventions were performed; first, a marsupialization, and 10 months after, the third molar extraction plus cyst enucleation, mucosa excision and the application of Carnoy's solution. Results: The anatomopathological exam confirmed diagnosis of OKC. There was no evidence of recurrence after 2 years of follow-up. Conclusions: Marsupialization followed by surgical enucleation with mucosa excision and Carnoy's solution can help manage treatment of OKC, a lesion characterized by an aggressive behavior

Therapeutic management of the odontogenic keratocyst. An energetic approach with a conservative perspective and review of the current therapeutic options

Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination. This study reports a 12-year-old girl that presented an asymptomatic large radiolucent unilocular lesion associated to the crown of 3.8 that caused displacement of the molar and the inferior alveolar canal. Differential diagnosis included OKC, unicystic ameloblastoma, ameloblastic fibroma, dentigerous cyst and orthokeratinized odontogenic cyst. Two surgical interventions were performed; first, a marsupialization, and 10 months after, the third molar extraction plus cyst enucleation, mucosa excision and the application of Carnoy?s solution. The anatomopathological exam confirmed diagnosis of OKC. There was no evidence of recurrence after 2 years of follow-up. Marsupialization followed by surgical enucleation with mucosa excision and Carnoy?s solution can help manage treatment of OKC, a lesion characterized by an aggressive behavior

Using computer-aided detection in mammography as a decision support

Contains fulltext : 87548.pdf (publisher's version ) (Closed access)OBJECTIVE: To evaluate an interactive computer-aided detection (CAD) system for reading mammograms to improve decision making. METHODS: A dedicated mammographic workstation has been developed in which readers can probe image locations for the presence of CAD information. If present, CAD findings are displayed with the computed malignancy rating. A reader study was conducted in which four screening radiologists and five non-radiologists participated to study the effect of this system on detection performance. The participants read 120 cases of which 40 cases had a malignant mass that was missed at the original screening. The readers read each mammogram both with and without CAD in separate sessions. Each reader reported localized findings and assigned a malignancy score per finding. Mean sensitivity was computed in an interval of false-positive fractions less than 10%. RESULTS: Mean sensitivity was 25.1% in the sessions without CAD and 34.8% in the CAD-assisted sessions. The increase in detection performance was significant (p = 0.012). Average reading time was 84.7 +/- 61.5 s/case in the unaided sessions and was not significantly higher when interactive CAD was used (85.9 +/- 57.8 s/case). CONCLUSION: Interactive use of CAD in mammography may be more effective than traditional CAD for improving mass detection without affecting reading time.1 oktober 201

Relativistic jet motion in the core of the radio-loud quasar J1101+7225

Multi-epoch GHz Very Long Baseline Interferometry (VLBI) data of the radio-loud quasar J1101+7225 were analyzed to estimate the proper motion of extended optically thin jet components. Two components separated from the core could be mapped at 1.66 GHz, which is consistent with earlier observations. In one case we found evidence of high apparent superluminal motion (beta_app= 22.5+/-4) at large (deprojected) distances to the core (22 mas ~ 4 kpc at z= 1.46). Typically in other quasars such high separation velocities are only found much closer to the core component. Furthermore the Doppler factor, the magnetic field strength, and the angular size of the optically thick core were derived using published X-ray data. Analysis of 5 GHz VLBI data reveals the existence of further jet components within the central 5 mas. Additionally the data published so far on the GHz-spectrum were discussed at all angular resolutions. J1101+7225 turns out to be a standard quasar for studying different aspects of radio jet kinematics out to kpc-scales.Comment: 8 pages, 5 figures, accepted by A&