Autonomous Shopping Cart

In shopping centers across the United States, customers must return shopping carts after they used them by themselves. For a variety of reasons, a significant number of shopping carts are left in parking lots after being used. This results in expenses to the store in the form of damaged carts, man hours required to return each one, and law suits from customers whose cars are damaged by free carts. This project is an add-on mechanism by which allows shopping carts to return to the shopping center autonomously. The cart should be able to locate a preset track that is set in the parking lot and from this track return itself to the shopping center. This system would utilized a motor and wheels located on the rear of the cart, enabling it to be retrofitted to carts currently in use without impeding the cart’s ability to stack. This statement should evolve as your project progresses

Lone-Pair-Induced Topicity Observed in Macrobicyclic Tetra-thia Lactams and Cryptands: Synthesis, Spectral Identification, and Computational Assessment

The synthesis of a rigid macrobicyclic N,S lactam <b>L1</b> and a topologically favored in/in N,S cryptand <b>L2</b> are reported with X-ray structure analysis, dynamic correlation NMR spectroscopy, and computational analysis. Lactam <b>L1</b> exhibits two distinct rotameric conformations (plus their enantiomeric counterparts) at 25 °C, as confirmed via NMR spectroscopy and computational analysis. Coalescence of the resonances of <b>L1</b> was observed at 115 °C, allowing for complete nuclei to frequency correlation. Combining computational investigations with experimental data, topological equilibria and relative energies/strain relating to the perturbation of the pore were determined. Due to the increased conformational strain of the N₂S₂ template, the nitrogen lone pairs in <b>L2</b> elicit a unique transannular interaction, resulting in a thermodynamically favored in/in nephroidal racemate. The combination of preferred topology, steric relief, and electronic localization of <b>L2</b> induces a chiral environment imparted through the amine with a computed inversion barrier of 10.3 kcal mol^–1

Lone-Pair-Induced Topicity Observed in Macrobicyclic Tetra-thia Lactams and Cryptands: Synthesis, Spectral Identification, and Computational Assessment

The synthesis of a rigid macrobicyclic N,S lactam <b>L1</b> and a topologically favored in/in N,S cryptand <b>L2</b> are reported with X-ray structure analysis, dynamic correlation NMR spectroscopy, and computational analysis. Lactam <b>L1</b> exhibits two distinct rotameric conformations (plus their enantiomeric counterparts) at 25 °C, as confirmed via NMR spectroscopy and computational analysis. Coalescence of the resonances of <b>L1</b> was observed at 115 °C, allowing for complete nuclei to frequency correlation. Combining computational investigations with experimental data, topological equilibria and relative energies/strain relating to the perturbation of the pore were determined. Due to the increased conformational strain of the N₂S₂ template, the nitrogen lone pairs in <b>L2</b> elicit a unique transannular interaction, resulting in a thermodynamically favored in/in nephroidal racemate. The combination of preferred topology, steric relief, and electronic localization of <b>L2</b> induces a chiral environment imparted through the amine with a computed inversion barrier of 10.3 kcal mol^–1

Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society

Molecular Technology and Informatics for Personalised Medicine and Healt

Lone-Pair-Induced Topicity Observed in Macrobicyclic Tetra-thia Lactams and Cryptands: Synthesis, Spectral Identification, and Computational Assessment

The synthesis of a rigid macrobicyclic N,S lactam <b>L1</b> and a topologically favored in/in N,S cryptand <b>L2</b> are reported with X-ray structure analysis, dynamic correlation NMR spectroscopy, and computational analysis. Lactam <b>L1</b> exhibits two distinct rotameric conformations (plus their enantiomeric counterparts) at 25 °C, as confirmed via NMR spectroscopy and computational analysis. Coalescence of the resonances of <b>L1</b> was observed at 115 °C, allowing for complete nuclei to frequency correlation. Combining computational investigations with experimental data, topological equilibria and relative energies/strain relating to the perturbation of the pore were determined. Due to the increased conformational strain of the N₂S₂ template, the nitrogen lone pairs in <b>L2</b> elicit a unique transannular interaction, resulting in a thermodynamically favored in/in nephroidal racemate. The combination of preferred topology, steric relief, and electronic localization of <b>L2</b> induces a chiral environment imparted through the amine with a computed inversion barrier of 10.3 kcal mol^–1

Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of theHuman Genome Variation Society

There is now a convergence of two modes of genetic testing, that of testing a few candidate genes at a time based on suspicion of a specific genetic disease, and that of genomic testing, especially when a candidate gene(s) is not suspected or known. Both aim to interpret pathogenicity of identified genetic variants. The 2015 annual scientific meeting of the Human Genome Variation Society (HGVS; http://www.hgvs.org) was held on the 6th of October in Baltimore, MD, with the theme of “Pathogenicity Interpretation in the Age of Precision Medicine.” The HGVS is focusing attention on advancing the field of variant interpretation. Progress will require both new developments in analytical methods (in vitro, in silico, statistical, and other methods) and cooperation among scientific, clinical, and regulatory participants in developing and maintaining standards for all areas of pathogenicity assessment, variant nomenclature, and annotation. This year's meeting covered all of these areas

Abstract WP10: Impact of Prior Intravenous Thrombolysis on the Outcome of Emergent Carotid Stenting in Acute Stroke Patients With Tandem Occlusion: A Collaborative Pooled Analysis

International audienc