145 research outputs found
Using a Systematic Process to Develop a Method for Assessment of Professionalism in Speech-Language Pathology Graduate Students
This poster describes a systematic process of developing the assessment of student professionalism in Speech-Language Pathology. The process highlights: (1) developing professionalism indicators using the core values of the University and Department; (2) validating the indicators through reviewing professionalism described in peer programs and professional organizations, and (3) systematic data collection, tracking, and analysis
Spectroscopy of a single-carrier bilayer graphene quantum dot from time-resolved charge detection
We measured the spectrum of a single-carrier bilayer graphene quantum dot as
a function of both parallel and perpendicular magnetic fields, using a
time-resolved charge detection technique that gives access to individual tunnel
events. Thanks to our unprecedented energy resolution of 4eV, we could
distinguish all four levels of the dot's first orbital, in particular in the
range of magnetic fields where the first and second excited states cross
(mT). We thereby experimentally establish, the hitherto
extrapolated, single-charge carrier spectrum picture and provide a new upper
bound for the inter-valley mixing, equal to our energy resolution
Dipole coupling of a bilayer graphene quantum dot to a high-impedance microwave resonator
We implement circuit quantum electrodynamics (cQED) with quantum dots in
bilayer graphene, a maturing material platform for semiconductor qubits that
can host long-lived spin and valley states. The presented device combines a
high-impedance () superconducting
microwave resonator with a double quantum dot electrostatically defined in a
graphene-based van der Waals heterostructure. Electric dipole coupling between
the subsystems allows the resonator to sense the electric susceptibility of the
double quantum dot from which we reconstruct its charge stability diagram. We
achieve sensitive and fast detection with a signal-to-noise ratio of 3.5 within
1 integration time. The charge-photon interaction is
quantified in the dispersive and resonant regimes by comparing the
coupling-induced change in the resonator response to input-output theory,
yielding a maximal coupling strength of . Our
results introduce cQED as a probe for quantum dots in van der Waals materials
and indicate a path toward coherent charge-photon coupling with bilayer
graphene quantum dots.Comment: 9 pages, 4 figure
Nanoscale mapping and spectroscopy of non-radiative hyperbolic modes in hexagonal boron nitride nanostructures
The inherent crystal anisotropy of hexagonal boron nitride (hBN) sustains
naturally hyperbolic phonon polaritons, i.e. polaritons that can propagate with
very large wavevectors within the material volume, thereby enabling optical
confinement to exceedingly small dimensions. Indeed, previous research has
shown that nanometer-scale truncated nanocone hBN cavities, with deep
subwavelength dimensions, support three-dimensionally confined optical modes in
the mid-infrared. Due to optical selection rules, only a few of many such modes
predicted theoretically have been observed experimentally via far-field
reflection and scattering-type scanning near-field optical microscopy. The
Photothermal induced resonance (PTIR) technique probes optical and vibrational
resonances overcoming weak far-field emission by leveraging an atomic force
microscope (AFM) probe to transduce local sample expansion due to light
absorption. Here we show that PTIR enables the direct observation of previously
unobserved, dark hyperbolic modes of hBN nanostructures. Leveraging these
optical modes could yield a new degree of control over the electromagnetic
near-field concentration, polarization and angular momentum in nanophotonic
applications.Comment: 14 pages with references, 4 figure
Molecular gas and star formation in early-type galaxies
We present new mm interferometric and optical integral-field unit (IFU)
observations and construct a sample of 12 E and S0 galaxies with molecular gas
which have both CO and optical maps. The galaxies contain 2 x 10^7 to 5 x 10^9
M\odot of molecular gas distributed primarily in central discs or rings (radii
0.5 to 4 kpc). The molecular gas distributions are always coincident with
distributions of optically-obscuring dust that reveal tightly-wound spiral
structures in many cases. The ionised gas always approximately corotates with
the molecular gas, evidencing a link between these two gas components, yet star
formation is not always the domi- nant ionisation source. The galaxies with
less molecular gas tend to have [O III]/H{\beta} emission-line ratios at high
values not expected for star formation. Most E/S0s with molecular gas have
young or intermediate age stellar populations based on optical colours,
ultraviolet colours and absorption linestrengths. The few that appear purely
old lie close to the limit where such populations would be undetectable based
on the mass fractions of expected young to observed old stars. The 8{\mu}m
polycyclic aromatic hydrocarbon (PAH) and 24{\mu}m emission yield similar star
formation rate estimates of E/S0s, but the total infrared overpredicts the rate
due to a contribution to dust heating from older stars. The radio-far infrared
relation also has much more scatter than for other star-forming galaxies.
However, despite these biases and additional scatter, the derived star
formation rates locate the E/S0 galaxies within the large range of the
Schmidt-Kennicutt and constant efficiency star formation laws. Thus the star
formation process in E/S0s is not overwhelmingly different than in other
star-forming galaxies, although one of the more reliable tracers (24{\mu}m)
points to a possible lower star-formation efficiency at a given gas surface
density.Comment: submitted to MNRA
Interfacial Synthesis of Layer-Oriented 2D Conjugated Metal-Organic Framework Films towards Directional Charge Transport
The development of layer-oriented two-dimensional conjugated metal-organic frameworks (2D c-MOFs) enables an access to direct charge transport, dial-in lateral/vertical electronic devices and unveil transport mechanisms, but remains a significant synthetic challenge. Here we report the novel synthesis of metal-phthalocyanine-based p-type semiconducting 2D c-MOF films (Cu2[PcM-O8], M=Cu or Fe) with an unprecedented edge-on layer-orientation at the air/water interface. The edge-on structure for-mation is guided by the pre-organization of metal-phthalocyanine ligands, whose basal plane is perpendicular to the water surface due to their π-π interaction and hydrophobicity. Benefiting from the unique layer orientation, we are able to investigate the lateral and vertical conductivities by DC methods, and thus demonstrate an anisotropic charge transport in the resulting Cu2[PcCu-O8] film. The directional conductivity studies combined with theoretical calculation identify that the intrinsic conductivity is dominated by charge transfer along the interlayer pathway. Moreover, a macroscopic (cm2-size) Hall-effect measurement reveals a Hall mobility of ~4.4 cm2 V-1 s-1 for the obtained Cu2[PcCu-O8] film. The orientation control in semiconducting 2D c-MOFs will enable the develop-ment of various optoelectronic applications and the exploration of unique transport properties
In Silico Theoretical Molecular Modeling for Alzheimer’s Disease: The Nicotine-Curcumin Paradigm in Neuroprotection and Neurotherapy
The aggregation of the amyloid-β-peptide (AβP) into well-ordered fibrils has been considered as the key pathological marker of Alzheimer‘s disease. Molecular attributes related to the specific binding interactions, covalently and non-covalently, of a library of compounds targeting of conformational scaffolds were computed employing static lattice atomistic simulations and array constructions. A combinatorial approach using isobolographic analysis was stochastically modeled employing Artificial Neural Networks and a Design of Experiments approach, namely an orthogonal Face-Centered Central Composite Design for small molecules, such as curcumin and glycosylated nornicotine exhibiting concentration-dependent behavior on modulating AβP aggregation and oligomerization. This work provides a mathematical and in silico approach that constitutes a new frontier in providing neuroscientists with a template for in vitro and in vivo experimentation. In future this could potentially allow neuroscientists to adopt this in silico approach for the development of novel therapeutic interventions in the neuroprotection and neurotherapy of Alzheimer‘s disease. In addition, the neuroprotective entities identified in this study may also be valuable in this regard
The Paf oncogene is essential for hematopoietic stem cell function and development
The Paf oncogene is highly expressed in cycling hematopoietic stem cells (HSCs) and is required for the development of long-term HSCs
Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
A cross-regulation between type I IFN and TNFα has been proposed recently, where both cytokines are hypothesized to counteract each other. According to this model, different autoimmune diseases can be viewed as disequilibrium between both cytokines. As this model may have important clinical implications, the present review summarizes and discusses the currently available clinical evidence arguing for or against the proposed cross-regulation between TNFα and type I IFN. In addition, we review how this cross-regulation works at the cellular and molecular levels. Finally, we discuss the clinical relevance of this proposed cross-regulation for biological therapies such as type I IFN or anti-TNFα treatment
The Overseeing Mother: Revisiting the Frontal-Pose Lady in the Wu Family Shrines in Second Century China
Located in present-day Jiaxiang in Shandong province, the Wu family shrines built during the second century in the Eastern Han dynasty (25–220) were among the best-known works in Chinese art history. Although for centuries scholars have exhaustively studied the pictorial programs, the frontal-pose female image situated on the second floor of the central pavilion carved at the rear wall of the shrines has remained a question. Beginning with the woman’s eyes, this article demonstrates that the image is more than a generic portrait (“hard motif ”), but rather represents “feminine overseeing from above” (“soft motif ”). This synthetic motif combines three different earlier motifs – the frontal-pose hostess enjoying entertainment, the elevated spectator, and the Queen Mother of the West. By creatively fusing the three motifs into one unity, the Jiaxiang artists lent to the frontal-pose lady a unique power: she not only dominated the center of the composition, but also, like a divine being, commanded a unified view of the surroundings on the lofty building, hence echoing the political reality of the empress mother’s “overseeing the court” in the second century during Eastern Han dynasty
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