Conformal Pomeron and Odderon in Strong Coupling

We discuss how exact conformal invariance in the strong coupling leads naturally through AdS/CFT correspondence to a systematic expansion for the Pomeron and Odderon intercepts in power of $\lambda^{-1/2}$, with $\lambda=g^2N_c$ the 't Hooft coupling. We also point out the importance of confinement for a realistic treatment of DIS in the HERA energy range.Comment: 8 pages, 3 figures, presented at the 2013 Low-x Workshop, May 30 - June 4 2013, Rehovot and Eilat, Israe

Affects of the Cold Water Pipe Depth in Ocean Thermal Energy Converter Plants with respect to Power Generation Efficiency

The Ocean provides an extensive renewable energy source. It is the exploitation of the thermal gradient between the warmed surface water and the deep cold water. A heat engine was developed to use the surface water as a heat source and the deep water as a cold source in order to convert thermal energy into mechanical energy and generate electricity. This process is called Ocean Thermal Energy Conversion (OTEC). This paper presents the three different types of OTEC power plants: closed-cycle, open-cycle and hybrid-cycle, showing real and conceptual examples of each. All three systems are analyzed in terms of gross power, net power, efficiency and size. Furthermore, the depth of the cold water pipe is discussed and related to the net power generation of the OTEC plant. The power generation efficiency of the plant increases as the gross power production increases. This is due to the depth of the cold water pipe and amount of power used by the cold water pipe pump

Evaluation of WRF mesoscale simulations and particle trajectory analysis for the MILAGRO field campaign

Accurate numerical simulations of the complex wind flows in the Mexico City Metropolitan Area (MCMA) can be an invaluable tool for interpreting the MILAGRO field campaign results. This paper uses three methods to evaluate numerical simulations of basin meteorology using the MM5 and WRF models: statistical comparisons with observations, "Concentration Field Analysis" (CFA) using measured air pollutant concentrations, and comparison of flow features using cluster analysis. CFA is shown to be a better indication of simulation quality than statistical metrics, and WRF simulations are shown to be an improvement on the MM5 ones. Comparisons with clusters identifies an under-representation of the drainage flows into the basin and an over-representation of wind shear in the boundary layer. Particle trajectories simulated with WRF-FLEXPART are then used to analyse the transport of the urban plume and show rapid venting and limited recirculation during MILAGRO. Lagrangian impacts were identified at the campaign supersites, and age spectra of the pollutants evaluated at those same sites. The evaluation presented in the paper show that mesoscale meteorological simulations are of sufficient accuracy to be useful for MILAGRO data analysis.National Science Foundation (U.S.) (Award ATM-0511803)National Science Foundation (U.S.) (Award ATM-0810950)National Science Foundation (U.S.) (Award ATM-0810931)Molina Center for Energy and the Environmen

Scaling Phenomena in Gravity from QCD

We present holographic arguments to predict properties of strongly coupled gravitational systems in terms of weakly coupled gauge theories. In particular we relate the latest computed value for the Choptuik critical exponent in black hole formation in five dimensions, \gamma_{5D}=0.412 \pm 1%, to the saturation exponent of four-dimensional Yang-Mills theory in the Regge limit, \gamma_{BFKL}\simeq 0.410.Comment: 13 pages. To Pere Pascual, in memoriam. v2: minor changes. Typos corrected and references added. v3: conclusions expanded, references added. To appear in Physics Letters

Effect of Different Amounts of Volcanic Ash from the Taal Volcano Eruption to the Growth of Ocimum basilicum (Basil)

Volcanic eruptions have a tremendous impact on an area that often leads to the destruction of the environment, human injuries, and even death. However, this research emphasizes one specific outcome unique to volcanic eruptions. The study aims to shed light upon the beneficial applications of volcanic ash to determine whether or not volcanic ash has advantageous botanical properties that could potentially enhance the growth of Ocimum basilicum (basil). In 8 weeks, four different concentrations (VA-0, VA-0.5, VA-1, and VA-2) of volcanic ash-loam soil composition were tested on basil plants. Three parameters were utilized to measure the plant\u27s growth: plant height, leaf count, and leaf surface area. Pot VA-1 achieved the highest plant height and leaf count increase among the four concentrations. As for the leaf surface area, VA-1 and VA-2 both yielded the highest growth from week 1 to week 8. Results support a beneficial relationship between volcanic ash and acid-loving plant

Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies

Combination; Drug therapy; ImmunotherapyCombinació; Teràpia farmacològica; ImmunoteràpiaCombinación; Terapia farmacológica; InmunoterapiaBackground Lymphocyte-activation gene 3 (LAG-3) is an inhibitory immunoreceptor that negatively regulates T-cell activation. This paper presents preclinical characterization of the LAG-3 inhibitor, ieramilimab (LAG525), and phase I data for the treatment of patients with advanced/metastatic solid tumors with ieramilimab ±the anti-programmed cell death-1 antibody, spartalizumab. Methods Eligible patients had advanced/metastatic solid tumors and progressed after, or were unsuitable for, standard-of-care therapy, including checkpoint inhibitors in some cases. Patients received ieramilimab ±spartalizumab across various dose-escalation schedules. The primary objective was to assess the maximum tolerated dose (MTD) or recommended phase II dose (RP2D). Results In total, 255 patients were allocated to single-agent ieramilimab (n=134) and combination (n=121) treatment arms. The majority (98%) had received prior antineoplastic therapy (median, 3). Four patients experienced dose-limiting toxicities in each treatment arm across various dosing cohorts. No MTD was reached. The RP2D on a 3-week schedule was declared as 400 mg ieramilimab plus 300 mg spartalizumab and, on a 4-week schedule (once every 4 weeks; Q4W), as 800 mg ieramilimab plus 400 mg spartalizumab; tumor target (LAG-3) suppression with 600 mg ieramilimab Q4W was predicted to be similar to the Q4W, RP2D schedule. Treatment-related adverse events (TRAEs) occurred in 75 (56%) and 84 (69%) patients in the single-agent and combination arms, respectively. Most common TRAEs were fatigue, gastrointestinal, and skin disorders, and were of mild severity; seven patients experienced at least one treatment-related serious adverse event in the single-agent (5%) and combination group (5.8%). Antitumor activity was observed in the combination arm, with 3 (2%) complete responses and 10 (8%) partial responses in a mixed population of tumor types. In the combination arm, eight patients (6.6%) experienced stable disease for 6 months or longer versus six patients (4.5%) in the single-agent arm. Responding patients trended towards having higher levels of immune gene expression, including CD8 and LAG3, in tumor tissue at baseline. Conclusions Ieramilimab was well tolerated as monotherapy and in combination with spartalizumab. The toxicity profile of ieramilimab in combination with spartalizumab was comparable to that of spartalizumab alone. Modest antitumor activity was seen with combination treatment.This study was sponsored by Novartis Pharmaceuticals Corporation and preliminary results were previously presented at ASCO 2018

In vitro Ruminal Gas Production Kinetics of Four Fodder Trees Ensiled With or Without Molasses and Urea

his study investigated if the addition of urea (U), molasses (M) or their 1:1 (v/v) mixture during ensiling increases the nutritional value of forage from four fodder trees (Prunus persica, Leucaena esculenta, Acacia farnesiana, and Prunus domestica). Forage samples of fodder trees were collected in triplicate (three individual samples of each species) and subjected to an in vitro gas production (GP) procedure. Fermentation at 24 h (GP24), short-chain volatile fatty acids (SCFA), and microbial crude protein production (MCP), in vitro organic matter digestibility (OMD), metabolizable energy (ME) and dry matter degradability (DMD) were estimated. Forage samples were incubated for 72 h in an incubator at 39ºC and the volume of GP was recorded at 2, 4, 6, 8, 10, 12, 24, 48, and 72 h of incubation using the reading pressure technique. The rumen fermentation profiles were highest for P. persica, which showed the highest (P<0.0001) DMD, ME, OMD, SCFA, GP24 and MCP. On the other hand L. esculenta had the lowest (P<0.0001) DMD, SCFA, MCP; P. domestica had the lowest (P<0.0001) OMD. The addition of M to silage increased (P<0.0001) ME and OMD, as well as GP. However, the addition of U and the mixture of U and M reduced (P<0.0001) DMD, ME, OMD, SCFA, GY24 and MCP. These results show that P. persica has the highest nutritive value and L. esculenta the lowest for ruminants. Additionally, the addition of M to forage from fodder trees increases rumen GP and fermentation, which may improve nutrient utilization in ruminants