Drosophila melanogaster mutant tan

Drosophila melanogaster gene tan was originally discovered in the early 20th century as a mutant strain lacking the dark pi gment pattern of wild-type (wt) f lies and, therefore, showing a light yellowish brown color (McEwen, 1918). Flies lack ing Tan function also exhibited abnormalities in vision (Benzer, 1967; Inoue et al. , 1988; True et al. , 2005), and tan males displayed an abnormal courtship behavior (Cook, 1980; Tomkins et al. , 1982). tan 1 ( t 1 ) and tan 3 ( t 3 ) alleles were found as spontaneous mutations, t 3 mutant being apparently lighter than t 1 (Brehme, 1941). tan is the structural gene for N- β -alanyldopamine hydrolase (NBAD-hydrolase or Tan protein), the enzyme that generates dopamine (DA) from NBAD (Wright, 1987; True et al. , 2005). Tan is expressed as a precursor protein of 43.7 kDa. Th is precursor is clea ved into two subunits of 29.9 and 13.8 kDa that apparently conform together a he terodimeric active protein (Wagner et al. , 2007). The enzyme that generates NBAD from DA, th e opposite reaction to the one catalyzed by Tan, is the NBAD-synthase or E bony protein (Wright, 1987; Pérez et al ., 1997), which is codified by the gene ebony . Since both Tan and Ebony ar e involved in cuticle tanni ng, carcinine re gulation, and NBAD metabolism in nervous tissue (Wright, 1987; Pérez et al. , 1997, 2004; Hovemann et al. , 1998; Borycz et al. , 2002; True et al. , 2005), it has been suggested that they function together in a system regulating the levels of dopamine during cuticle sclerotization a nd histamine in the visual metabolism (Borycz et al. , 2002; Pérez et al. , 2010). During the last few years, several publicati ons appeared regarding NBAD-synthase (Wappner et al ., 1996a, b; Pérez et al ., 1997, 2002, 2004, 2010; Hovemann et al. , 1998; Borycz et al. , 2002; Wittkopp et al., 2002; Schachter et al ., 2007), but very little is known about tan (True et al. , 2005; Wagner et al. , 2007). Thus, it was important to furthe r characterize the NBAD-hydrolase in D. melanogaster wt and in mutants t 1 and t 3.Fil: Badaracco, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Quesada Allue, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Pérez, Martín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentin

Editorial : tan clara, tan vida

Fil: Hallú, Rubén E. Universidad de Buenos Aires; ArgentinaMientras la población humana se ha triplicado en sesenta años y, de ese total, la urbana ha crecido cinco veces en igual período, el acceso al agua dulce se ha restringido y los riesgos sobre su disponibilidad futura han aumentado. Los recursos, las regulaciones y las estrategias están disponibles. Que esa disponibilidad alcance efectivamente a todo humano en el más corto de los plazos posibles es una responsabilidad política global. Todas las perspectivas disciplinarias convergen, con la solvencia habitual, en este número de Encrucijadas dedicado a la tal vez más significativa de las encrucijadas; el agua

An Evaluation of the Cooperative System in the Philippines

The Philippine cooperative system has been characterized by success and failure. This paper explores the reasons for the circumstances, the problems plaguing the system and its implications on the movement in general. A review of various studies is conducted.cooperative system

Large tan(beta) effects in flavour physics

After a short introduction to the SUSY flavour problem, we focus the attention on the MSSM with MFV and large $\tan\beta$. The theoretical motivations and the general features of this scenario are briefly reviewed. The possible signatures in low-energy flavour-violating observables are discussed, with particular attention to the role played by \BR(P\to\ell\nu), \BR(B_{s,d}\to \ell^+\ell^-) and \BR(\mu\to e \gamma)Comment: Submitted for the SUSY07 proceedings, 8 pages, 6 figure

Grand Unification Scale CP Violating Phases And The Electric Dipole Moment

The question of CP violating phases in supersymmetry and electric dipole moments (EDMs) is considered within the framework of supergravity grand unification (GUT) models with a light ($\stackrel{<}{\sim}$1 TeV) mass spectrum. In the minimal model, the nearness of the t-quark Landau pole automatically suppresses the t-quark cubic soft breaking phase at the electroweak scale. However, current EDM data require the quadratic soft breaking phase to be small at the electroweak scale unless tan$\beta$ is small (tan$\beta\stackrel{<}{\sim}$3), and the EDM data combined with the requirement of electroweak symmetry breaking require this phase to be both large and highly fine tuned at the GUT scale unless tan$\beta$ is small. Non minimal models are also examined, and generally show the same behavior.Comment: 28 pages, latex, 15 figure

España y Estados Unidos: tan cerca y, sin embargo, tan lejos

Este Documento de Trabajo actualiza brevemente el libro España y EEUU: en busca del redescubrimiento mutuo, publicado por el Real Instituto Elcano en noviembre de 2005. En líneas generales, sigue la misma estructura, pero incorpora las cifras y los materiales más recientes relativos a los aspectos comerciales, de inversión, políticos y culturales de la relación ente España y EEUU

Ammonia emissions from livestock production in Chile: an inventory and uncertainty analysis

Indexación: Web of Science; Scielo.The objective of this work was to quantify the country's NH3 emissions from livestock production. This calculation was based on the mass flow of total ammoniacal nitrogen (TAN). The analysis was performed for all 15 geographical regions in Chile. The definition of livestock subcategories was based on data from the Chilean Agriculture and Forestry Census as well as technical reports published by the Chilean National Statistics Institute. Significant differences were observed among the sources of livestock emissions in Chile's regions, and there was high variability depending on the degree of livestock confinement. In 2013, the total calculated emissions were 69.1 kt NH3/year (± 31.1). The O’Higgins Region had the highest NH3 emissions in Chile, representing 45% of the total. In terms of livestock production, 45% of the emissions were generated by pigs, 22% by poultry, 16% by cattle, 11% by equines and 4% by sheep. Emissions from the TAN that was available during manure and slurry management and the degree of animal confinement were the primary sources of uncertainty. This uncertainty could be greatly reduced by developing regional emission factors and by including the degree of animal confinement in Chile's national statistics such as the Agriculture, Livestock and Forestry Census.http://www.scielo.cl/scielo.php?pid=S0718-95162016005000005&script=sci_abstrac

Strain-induced quantum dots by self-organized stressors

Novel in situ method to produce quantum dots is reported. Three‐dimensional confinement of carriers to a GaInAs/GaAs quantum welldots is observed by photoluminescence. The confinement potential is induced by stressors, formed by self‐organizing growth of InP nanoscale islands on top barrier GaAssurface. Two transitions arising from the strain‐induced quantum dots produced by two types of InP islands are identified. The luminescence from higher electronic states of the quantum dots having a level splitting of 8 meV is also observed.Peer reviewe