Probabilistic Clustering of Time-Evolving Distance Data

We present a novel probabilistic clustering model for objects that are represented via pairwise distances and observed at different time points. The proposed method utilizes the information given by adjacent time points to find the underlying cluster structure and obtain a smooth cluster evolution. This approach allows the number of objects and clusters to differ at every time point, and no identification on the identities of the objects is needed. Further, the model does not require the number of clusters being specified in advance -- they are instead determined automatically using a Dirichlet process prior. We validate our model on synthetic data showing that the proposed method is more accurate than state-of-the-art clustering methods. Finally, we use our dynamic clustering model to analyze and illustrate the evolution of brain cancer patients over time

Digital unreason: Jordan Wolfson’s ‘Evil Jew’

This article privileges an analysis of the artwork Animation, masks (2011) by the Jewish-American contemporary artist Jordan Wolfson. This animated film is over 10 minutes long and features only one character, based on a collection of references Wolfson found under the Google search terms ‘evil Jew’ and ‘Shylock’. One of the key references for this ‘evil Jew’ stereotype, ‘Le Happy Merchant’, is a popular meme circulating on the 4chan media network and has become a mascot of the so called ‘alt-right’ – a loose network of racists and anti-Semites that became militant supporters of the 2016 Donald Trump presidential campaign and presidency. In Wolfson’s version of the meme, professional American animators were hired to give this stereotype the illusion of life. The result is a fascist stereotype restaged as an endearing Dreamworks character, unpredictable and incoherent, lurching between violent and placatory gestures. Rather than attempt a close analysis, this article argues that Wolfson’s social link to stereotype, conspiracy theory and fascist rebellion requires greater interrogation in light of the Donald Trump campaign, Brexit and the Le Pen candidacy. In all these campaigns, a vitalistic critique of metropolitan ‘elites’ or ‘globalists’ became the anti-establishment pretext for verbal assaults on immigrants, people of colour and Muslims. Alberto Toscano and Jeff Kinkle in Cartographies of the Absolute (2015) connect a popular upsurge in conspiratorial thinking to an absented critique of capitalism. They claim that if the abstract and impersonal character of capitalism is never awarded popular interrogation, conspiracy theory is an easy substitute, leaving the door open to anti-Semitic and racist projections. In turn, they call for art and popular culture that creates a systematic link to the bewildering movements of late capitalism, rather than fall into conspiratorial thinking. In this article, the author suggests that Wolfson in Animation, masks is using animation and caricature to bear witness to the circulation of anti-Semitic conspiracy and the narcissistic social networks that have been emboldened by the rise of the international far Right. However, by ambivalently playing around with stereotype, Wolfson also risks falling into complicity with forces of unreason that are indifferent to ironic treatment. This article discusses the critical contributions and limitations of this artwork, leading to an evaluation of Wolfson’s conceptual performance as a whole

Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa)

Peer reviewedPublisher PD

Crisis discharges and readmission risk in acute psychiatric male inpatients

<p>Abstract</p> <p>Background</p> <p>Severe pressures on beds in psychiatric services have led to the implementation of an early ("crisis") discharge policy in the Western Cape, South Africa. The study examined the effect of this policy and length of hospital stay (LOS) on readmission rates in one psychiatric hospital in South Africa.</p> <p>Methods</p> <p>Discharge summaries of adult male patients (<it>n </it>= 438) admitted to Stikland Psychiatric Hospital during 2004 were retrospectively examined. Each patient's clinical course was then analysed for the period between January 1^st, 2004, and August 31^st, 2006.</p> <p>Results</p> <p>Although shorter LOS was associated with decreased readmission rates, the effect of crisis discharges was far more powerful. Patients discharged as usual had a far lower risk of readmission than those discharged due to bed pressures (i.e. crisis discharge).</p> <p>Conclusion</p> <p>Increased risks associated with the early discharge policy necessitate the urgent review of the current management of bed shortages in this inpatient facility. The strengthening of community initiatives, particularly assertive outreach could be a way forward.</p

Idiosyncratic deals for older workers: increased heterogeneity among older workers enhance the need for i-Deals

The rapid aging of the workforce throughout the Western world and parts of Asia, including Japan and China, poses many challenges on contemporary organizations (European Commission, 2010 ; Wang & Shultz, 2010 ). The Babyboom generation, consisting of workers born between 1945 and 1965, constitutes a large part of the current workforce. Due to decreased fertility rates, there are fewer younger workers entering the labor market, as a consequence of which the percentage of older workers is rapidly increasing (Truxillo & Fraccaroli, 2013 ). Consequently, organizations are increasingly aware that the employee population is changing, and that strategies to employ, motivate, and retain workers have to be adapted accordingly. It is no longer suffi cient for organizations to focus on employing younger workers (e.g., through designing traineeships for graduates), because the infl ux of younger workers in the labor market is stagnating, which is in particular present in certain sectors, such as technical occupations and health care (Polat, Bal, & Jansen, 2012 ). Hence, organizations increasingly will have to rely on older workers, and try to retain older workers, and motivate them to stay longer in the workforce. Similarly, governments across Europe are also increasing offi cial retirement ages, and making it fi nancially less attractive for older workers to retire early (European Commission)

Structure of a lectin from Canavalia gladiata seeds: new structural insights for old molecules

<p>Abstract</p> <p>Background</p> <p>Lectins are mainly described as simple carbohydrate-binding proteins. Previous studies have tried to identify other binding sites, which possible recognize plant hormones, secondary metabolites, and isolated amino acid residues. We report the crystal structure of a lectin isolated from <it>Canavalia gladiata </it>seeds (CGL), describing a new binding pocket, which may be related to pathogen resistance activity in ConA-like lectins; a site where a non-protein amino-acid, α-aminobutyric acid (Abu), is bound.</p> <p>Results</p> <p>The overall structure of native CGL and complexed with α-methyl-mannoside and Abu have been refined at 2.3 Å and 2.31 Å resolution, respectively. Analysis of the electron density maps of the CGL structure shows clearly the presence of Abu, which was confirmed by mass spectrometry.</p> <p>Conclusion</p> <p>The presence of Abu in a plant lectin structure strongly indicates the ability of lectins on carrying secondary metabolites. Comparison of the amino acids composing the site with other legume lectins revealed that this site is conserved, providing an evidence of the biological relevance of this site. This new action of lectins strengthens their role in defense mechanisms in plants.</p