Measurement of body composition in cancer patients using CT planning scan at the third lumbar vertebra

OBJECTIVE: the main objective was to assess body composition in terms of skeletal muscle index (SMI), myosteatosis, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and intermuscular adipose tissue (IMAT) as an adjunct of information provided by radiotherapy CT planning scan. MATERIAL AND METHODS: a sample of 49 patients with lung and digestive cancers underwent a CT scan for radiotherapy treatment, which included measurements at the L3 region. Images were analyzed with a radiotherapy contouring software, using different Hounsfield Unit (HU) settings. Cross-sectional areas (cm2) were automatically computed by summing tissue pixels and multiplying by pixel surface area. Low SMI (cm2/m2) and muscle density (HU) were determined according to the recently established cut-off points. RESULTS: the prevalence of low SMI was detected in 46.94% of patients, being present in 8 women, 4 men with BMI < 25 kg/m2, and 11 men with BMI ≥ 25 kg/m2. The average mean skeletal attenuation of total skeletal muscle area was 29.02 (± 8.66) HU, and myosteatosis was present in 13 women (81.25%) and 31 men (93.94%). Mean SAT was 131.92 (± 76.80) cm2, mean VAT was 133.19 (± 85.28) cm2, and mean IMAT was 11.29 (± 12.86) cm2. CONCLUSION: skeletal muscle abnormalities are frequently present in cancer patients and a low SMI may also exist even in the presence of overweight. As CT scans are an important tool at any radiation oncology department, they could also be used to offer highly sensitive and specific information about body composition, as well as to detect early malnutrition before starting radiotherapy treatment

The Compact Linear Collider (CLIC) - 2018 Summary Report

The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear $e^+e^-$ collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years

Multi-objective optimization of the design of two-stage flash evaporators: Part 2. Multi-objective optimization

International audienc

Effect of pasture composition in cattle grazed systems on soil properties and nutrient cycling: impact on herbage, soil and cattle excreta

Full experimental details can be found in McAuliffe et al. (2020), https://doi.org/10.1016/j.agee.2020.106978, and Segura et al. (2023), https://doi.org/10.1016/j.jenvman.2022.117096. The experiment took place on the North Wyke Farm Platform (NWFP), a UK National Capability in SW England. The NWFP is split into a number of self-contained farms (‘farmlets’) that are managed according to different operation philosophies or practices. The NWFP is highly instrumented and monitored, and core NWFP datasets are open and include in-situ water flow and chemistry taken at 15-minute intervals; 15-minute Met measurements; 15-minute soil moisture measurements; 30-minute GHG emissions; soils, crop and botanical field survey data; livestock and crop performance data; and farm operational activities, and contextual information is also available. See https://nwfp.rothamsted.ac.uk/. At the time of the experiment, there were three farmlets on the NWFP with different pasture management strategies. Permanent pasture (PP), a perennial ryegrass monoculture (HS) which was sown with a high sugar Lolium perenne cv. AberMagic, and a white clover/perennial ryegrass mix (WC) with the same ryegrass variety as the HS pasture. The PP and HS pastures received N fertilizer at a standard rate, but the WC pastures did not due to the inclusion of a legume. Fields within a farmlet are cut for silage and grazed by cattle and sheep, with livestock grazing or consuming silage only from one farmlet. This experiment used a single field from each farmlet, chosen as they represent a trio of fields that typically undergo very similar timings in agricultural management, such as grazing by the same species at the same time, as far as is feasible. Within each field there were three experimental blocks each containing six plots (2.5 x 1.5 m). Each of the six plots within a block were randomised to controls or treatments. Treatments were dung, cattle urine, or synthetic urine. The dung was collected from fields within a farmlet, homogenised using a concrete mixer, and refrigerated in sealed barrels until application on the plots. Cattle urine was collected from cattle within a farmlet over the period of a couple of days, bulked, and frozen until application on the plots. Synthetic urine was included as a treatment to investigate the effect of pasture composition on N2O emissions to be tested without the confounding effects of different urine compositions. Three plots within each block were controls. One control plot in each block received no N fertilizer, while the other two plots in the PP and HS blocks were controls plus N fertilizer to replicate the rest of the field; the WC blocks had three controls with no N fertilizer as this farmlet does not receive N fertilizer. In some cases, only one of the two plus N fertilizer controls were analysed for some of the measurements. This dataset contains data on herbage yield; soil moisture; soil physical properties (bulk density, mean weight density, soil loss through 50 µm sieve); soil chemistry (various measures of carbon and nitrogen content, pH and ergosterol); herbage and manure total carbon and nitrogen; micro- and macronutrient concentrations of herbage, soil, urine and manure; and earthworm counts. Urine and manure are characterised before being applied as treatments, while soil and forage samples were taken at various time points from shortly before the application of treatments through to several months later. In the case of the micro- and macronutrient content of soil as assessed by ICP, baseline samples – taken prior to the implementation of the farmlet treatments – are also included