Learning Design: reflections on a snapshot of the current landscape

The mounting wealth of open and readily available information and the swift evolution of social, mobile and creative technologies warrant a re-conceptualisation of the role of educators: from providers of knowledge to designers of learning. This need is being addressed by a growing trend of research in Learning Design. Responding to this trend, the Art and Science of Learning Design workshop brought together leading voices in the field and provided a forum for discussing its key issues. It focused on three thematic axes: practices and methods, tools and resources, and theoretical frameworks. This paper reviews some definitions of Learning Design and then summarises the main contributions to the workshop. Drawing upon these, we identify three key challenges for Learning Design that suggest directions for future research

Effects of pore modification on the templating of guest molecules in a 2D honeycomb network

This work was supported by the UK Engineering Physical Sciences Research Council (EPRSC) and the EU.1,7-Diadamantanethioperylene-3,4:9,10-tetracarboxylic diimide, (Ad-S)(2)-PTCDI, adsorbed on Au (111) from solution was investigated by scanning tunneling microscopy (STM) and X-ray photoelectron spectroscopy (XPS). (Ad-S)(2)-PTCDI forms a well-ordered monolayer whose structure is described by a (2 root 63 x root 19) R19.1 degrees chiral unit cell containing four molecules. Codeposition of (Ad-S)(2)-PTCDI with 1,3,5-triazine-2,4,6-triamine (melamine) yields a honeycomb network whose (7 root 3 x 7 root 3)R30 degrees unit cell is identical to the unsubstituted PTCDI/melamine analogue. The effect of the adamantyl thioether moieties on the adsorption of guest molecules is investigated using adamantane thiol and C-60. While the thioether units do not affect the packing of adamantane thiol molecules a pronounced influence is seen in the case of fullerene. Pore modification involving different combinations of enantiomers of (Ad-S)(2)-PTCDI give rise to distinctly different arrangements of C-60 molecules. The diversity of patterns is further increased by the presence of unsubstituted PTCDI molecules.PostprintPeer reviewe

Cut-rose production in response to planting density in two contrasting cultivars

Growing in lower planting density, rose plants produce more assimilates, which can be used to produce more and/or heavier flowering shoots. The effect of planting density was investigated during a period including the first five flowering flushes of a young crop. In a heated greenhouse two cut-rose cultivars were grown under bent canopy management. ‘Akito’ on own-roots and ‘Ilios’ on ‘Natal Briar’ rootstock were planted with densities of 8 and 4 plants per m2. Starting at the end of June 2007, flowering shoots were harvested over a time span of eight months. Based on ‘flowering flushes’, times of high harvest rate, the harvesting time span could be divided into five consecutive periods, each including one flush. The cultivars showed contrasting responses to planting density. In the first three periods the response in ‘Ilios’ was extraordinary, because at low density plants did not produce more flowering shoots, as would be expected. However, the response in shoot fresh weight was larger for ‘Ilios’ than for ‘Akito’, 35% compared to 21% over the entire study period. The results imply that there was a genetic difference in the effect of assimilate availability and/or local light environment. During the first three periods, these factors can not have influenced shoot number in ‘Ilios’, while they did in ‘Akito’. It is suggested that decreases of assimilate availability in winter caused the shoot number response to emerge for ‘Ilios’ later on

alpha-nucleus potentials for the neutron-deficient p nuclei

alpha-nucleus potentials are one important ingredient for the understanding of the nucleosynthesis of heavy neutron-deficient p nuclei in the astrophysical gamma-process where these p nuclei are produced by a series of (gamma,n), (gamma,p), and (gamma,alpha) reactions. I present an improved alpha-nucleus potential at the astrophysically relevant sub-Coulomb energies which is derived from the analysis of alpha decay data and from a previously established systematic behavior of double-folding potentials.Comment: 6 pages, 3 figures, accepted for publication in Phys. Rev.

Kaon and Hyperon Form Factors in Kaon Electroproduction on the Nucleon

The electromagnetic form factors of strange mesons and baryons are studied by means of kaon electroproduction on the nucleon. The response functions that are sensitive to the K0, Lambda, Sigma, and KK*\gamma transition form factors are systematically explored. The effects of these form factors on several response functions are discussed.Comment: 10 pages, Latex2e, 12 postscript figures. Invited talk given at the International Conference on Hypernuclear and Strange Particle Physics (HYP97), Brookhaven National Laboratory, USA, October 13-18, 1997. To be published in Nucl. Phys.

Biological Regulation in the Formation of Hypoxia

2010 S.C. Water Resources Conference - Science and Policy Challenges for a Sustainable Futur

I Love My Wife But Oh! Her Family

https://digitalcommons.library.umaine.edu/mmb-vp/4370/thumbnail.jp

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes

ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods use conservative approaches aimed to minimize false-positive transcription factor targets. We present a model with improved sensitivity in detecting binding events from ChIP-on-chip data. Biochemically validated analysis in human T-cells reveals that three transcription factor oncogenes, NOTCH1, MYC, and HES1, bind one order of magnitude more promoters than previously thought. Gene expression profiling upon NOTCH1 inhibition shows broad-scale functional regulation across the entire range of predicted target genes, establishing a closer link between occupancy and regulation. Finally, the resolution of a more complete map of transcriptional targets reveals that MYC binds nearly all promoters bound by NOTCH1. Overall, these results suggest an unappreciated complexity of transcriptional regulatory networks and highlight the fundamental importance of genome-scale analysis to represent transcriptional programs