Biocompatible/ Bioresorbable Polymer Based Silver Nanaomaterial Coatng for Chronic Indwelling Medical Devices and Bioscaffolds for Tissue Regrowth

The objective of this study is to synthesize and characterize antimicrobial, bio-polymer based silver nanomaterials composite coatings, for use in chronic indwelling medical devices, and bioscaffolds. The coatings and bioscaffolds are comprised of novel biomass mediated silver nano particles (SNP) that are biocompatible, highly concentrated, highly pure, cost-effective, polydispersed and compatible with a range of polymer systems applicable for use with existing chronic indwelling medical devices. This thesis is divided into three main chapters. In Chapter 1, detailed review on the need for antimicrobial nanocomposite coatings for chronic indwelling medical devices along with different SNP synthesis and characterization methods is provided. In Chapter 2 a comprehensive description of biocompatible/bioresorbable poly (L-lactide) (PLLA) based thin film coatings comprised of novel 25-75 nm silver nano particles SNP is provided. The particle and film morphology is characterized using Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM) and UV-Visible Spectroscopy. The release rate of SNP is profiled by Thermogravimetric Analysis (TGA) and Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES). These coatings, suitable for chronic indwelling devices, drastically reduce the microbial biofilm formed by Staphylococcus aureus and Escherichia coli by 3-5 log reduction. This chapter details the synthesis of PLLA cast-coatings and the procedure to embed SNP, an antimicrobial agent, at a range of concentrations to identify an optimal SNP concentration of 700-800 ppm that efficacious and non-cytotoxic to human epithelial carcinoma cells (HeLa). Chapter 3 explains the procedure of making biocompatible/bioresorbable PLLA-PEG co-polymer block bioscaffolds designed to degrade and resorb at a controlled rate while providing a suitable substrate for tissue regrowth. The antimicrobial properties of these porous bioscaffolds are tested across varying concentrations of biomass mediated SNP, to determine an efficacious antimicrobial concentration. The bioscaffolds are efficacious as it reduces the Staphylococcus aureus and Escherichia coli biofilm by 92.5- 99.9%, respectively, at an antimicrobial SNP concentration of 800ppm

Abdominal wall hernias in upper Egypt: A different spectrum

Background: Hernia is a very common surgical condition affecting all ages and both sexes. To describe and find the possible differences in the spectrum of abdominal hernias and document trends in their management, we carried out a descriptive study of all patients with abdominal hernias admitted to a single tertiary institution during a five years period.Methods: A descriptive study of all abdominal wall hernia repairs from Jan. 2002 to Jan. 2007. Data collection was done using patients’ medical records that were included in the hospital archives. Variables included age, sex, final diagnosis and type of repair.Results: 2516 hernia repairs were done. Inguinal hernias were the most common (56%), followed by adult umbilical hernia (22.7%), incisional hernia (10.3%), and epigastric hernia (7.4%). There is an increasing trend towards the use of synthetic mesh repair in different hernia varieties. Mesh repair in adult umbilical and incisional hernias has increased from 32 and 34.6% in 2002 to 63.8% and 90.7% in 2006 respectively.Conclusion: We have a higher relative frequency of adult umbilical and epigastric hernia in Upper Egypt. There is a change in the pattern of hernia repairs with increasing trend towards mesh repair in different varieties

Search using social networks

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 59-61).In this thesis, we present an approach to the problem of personalized web search which makes use of the searcher's social network, in addition to the hyper-link based score used in most search engines. This combination of social and absolute search scores aims to improve the visibility of information that is relevant to the searcher, while maintaining any absolute measures of document importance . In our approach we adopt a flexible framework for combining information from different sources using Rank Aggregation techniques. Our search system, implemented using Java and Python, covers all the events and web pages present on MIT owned websites. We discuss the theory, design,and implementation of this system in details.by Ammar Ammar.M.Eng

Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents

Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development.We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years.The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty.The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics

On The Dimensional Methods in Rare b Decays

Since several years there exists a question whether the dimensional reduction and the usual dimensional regularization give different results for the QCD-improved $b \rightarrow s \gamma$ and $b \rightarrow s$ $gluon$ decay rates. Here it is demonstrated explicitly that this is not the case: As long as physically meaningful quantities are considered, the results obtained with help of both techniques agree.Comment: 14 pages (including 1 page figures

Ten simple rules for principled simulation modelling

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Improving performance and the reliability of off-site pre-cast concrete production operations using simulation optimisation

The increased use of precast components in building and heavy civil engineering projects has led to the introduction of innovative management and scheduling systems to meet the demand for increased reliability, efficiency and cost reduction. The aim of this study is to develop an innovative crew allocation system that can efficiently allocate crews of workers to labour-intensive repetitive processes. The objective is to improve off-site pre-cast production operations using Multi-Layered Genetic Algorithms. The Multi-Layered concept emerged in response to the modelling requirements of different sets of labour inputs. As part of the techniques used in developing the Crew Allocation “SIM_Crew” System, a process mapping methodology is used to model the processes of precast concrete operations and to provide the framework and input required for simulation. Process simulation is then used to model and imitate all production processes, and Genetic Algorithms are embedded within the simulation model to provide a rapid and intelligent search. A Multi-Layered chromosome is used to store different sets of inputs such as crews working on different shifts and process priorities. A ‘Class Interval’ selection strategy is developed to improve the chance of selecting the most promising chromosomes for further investigation. Multi-Layered Dynamic crossover and mutation operators are developed to increase the randomness of the searching mechanism for solutions in the solution space. The results illustrate that adopting different combinations of crews of workers has a substantial impact on the labour allocation cost and this should lead to increased efficiency and lower production cost. In addition, the results of the simulation show that minimum throughput time, minimum process-waiting time and optimal resource utilisation profiles can be achieved when compared to a real-life case study

Fuzzy Multicriteria Decision-Making Model for Time-Cost-Risk Trade-Off Optimization in Construction Projects

As is often the case in project scheduling, when the project duration is shortened to decrease total cost, the total float is lost resulting in added critical or nearly critical activities. This, in turn, results in decreasing the probability of completing the project on time and increases the risk of schedule delays. To solve this problem, this research developed a fuzzy multicriteria decision-making (FMCDM) model. The objective of this model is to help project managers improve their decisions regarding time-cost-risk trade-offs (TCRTO) in construction projects. In this model, an optimization algorithm based on fuzzy logic and analytic hierarchy process (AHP) has been used to analyze the time-cost-risk trade-off alternatives and select the best one based on selected criteria. The algorithm was implemented in the MATLAB software and applied to two case studies to verify and validate the presented model. The presented FMCDM model could help produce a more reliable schedule and mitigate the risk of projects running overbudget or behind schedule. Further, this model is a powerful decision-making instrument to help managers reduce uncertainties and improve the accuracy of time-cost-risk trade-offs. The presented FMCDM model employed fuzzy linguistic terms, which provide decision-makers with the opportunity to give their judgments as intervals comparing to fixed value judgments. In conclusion, the presented FMCDM model has high robustness, and it is an attractive alternative to the traditional methods to solve the time-cost-risk trade-off problem in construction

A prospective, randomised comparison of continuous paravertebral block and continuous intercostal nerve block for post-thoracotomy pain

Background: This study aimed to compare paravertebral block and continuous intercostal nerve block after thoracotomy.Methods: Forty-six adult patients undergoing elective posterolateral thoracotomy were randomised to receive either a continuous intercostal nerve blockade or a paravertebral block. Opioid consumption and postoperative pain were assessed for 48 hours .Pulmonary function was assessed by forced expiratory volume in 1 s (FEV1) recorded at 4 hours intervals.Results: With respect to the objective visual assessment (VAS), both techniques were effective for post thoracotomy pain. The average VAS score at rest was 29±10mm for paravertebral block and 31.5±11mm for continuous intercostal nerve block. The average VAS score on coughing was 36±14mm for the first one and 4 ±14mm for the second group. Pain at rest was similar in both groups. Pain scores on coughing were lower in paravertebral block group at 42 and 48 hours. Post-thoracotomy function was better preserved with paravertebral block. No difference was found among the two groups for side effects related to technique, major morbidity or duration of hospitalisation.Conclusion: We found that continuous intercostal nerve block and paravertebral block were effective and safe methods for post-thoracotomy pain.