488 research outputs found
Optical phase coherent timing of the Crab nebula pulsar with Iqueye at the ESO New Technology Telescope
The Crab nebula pulsar was observed in 2009 January and December with a novel
very fast optical photon counter, Iqueye, mounted at the ESO 3.5 m New
Technology Telescope. Thanks to the exquisite quality of the Iqueye data, we
computed accurate phase coherent timing solutions for the two observing runs
and over the entire year 2009. Our statistical uncertainty on the determination
of the phase of the main pulse and the rotational period of the pulsar for
short (a few days) time intervals are s and ~0.5 ps,
respectively. Comparison with the Jodrell Bank radio ephemerides shows that the
optical pulse leads the radio one by ~240 s in January and ~160 s in
December, in agreement with a number of other measurements performed after
1996. A third-order polynomial fit adequately describes the spin-down for the
2009 January plus December optical observations. The phase noise is consistent
with being Gaussian distributed with a dispersion of s in most observations, in agreement with theoretical expectations for
photon noise-induced phase variability.Comment: 10 pages, 5 figures. Accepted for publication in Monthly Notices of
the Royal Astronomical Societ
QuantEYE: The Quantum Optics Instrument for OWL
QuantEYE is designed to be the highest time-resolution instrument on ESO:s
planned Overwhelmingly Large Telescope, devised to explore astrophysical
variability on microsecond and nanosecond scales, down to the quantum-optical
limit. Expected phenomena include instabilities of photon-gas bubbles in
accretion flows, p-mode oscillations in neutron stars, and quantum-optical
photon bunching in time. Precise timescales are both variable and unknown, and
studies must be of photon-stream statistics, e.g., their power spectra or
autocorrelations. Such functions increase with the square of the intensity,
implying an enormously increased sensitivity at the largest telescopes.
QuantEYE covers the optical, and its design involves an array of
photon-counting avalanche-diode detectors, each viewing one segment of the OWL
entrance pupil. QuantEYE will work already with a partially filled OWL main
mirror, and also without [full] adaptive optics.Comment: 7 pages; Proceedings from meeting 'Instrumentation for Extremely
Large Telescopes', held at Ringberg Castle, July 2005 (T.Herbst, ed.
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Machine learning methods for automatic silent speech recognition using a wearable graphene strain gauge sensor
Silent speech recognition is the ability to recognise intended speech without audio information. Useful applications can be found in situations where sound waves are not produced or cannot be heard. Examples include speakers with physical voice impairments or environments in which audio transference is not reliable or secure. Developing a device which can detect non-auditory signals and map them to intended phonation could be used to develop a device to assist in such situations. In this work, we propose a graphene-based strain gauge sensor which can be worn on the throat and detect small muscle movements and vibrations. Machine learning algorithms then decode the non-audio signals and create a prediction on intended speech. The proposed strain gauge sensor is highly wearable, utilising graphene’s unique and beneficial properties including strength, flexibility and high conductivity. A highly flexible and wearable sensor able to pick up small throat movements is fabricated by screen printing graphene onto lycra fabric. A framework for interpreting this information is proposed which explores the use of several machine learning techniques to predict intended words from the signals. A dataset of 15 unique words and four movements, each with 20 repetitions, was developed and used for the training of the machine learning algorithms. The results demonstrate the ability for such sensors to be able to predict spoken words. We produced a word accuracy rate of 55% on the word dataset and 85% on the movements dataset. This work demonstrates a proof-of-concept for the viability of combining a highly wearable graphene strain gauge and machine leaning methods to automate silent speech recognition.EP/S023046/
Ten Years of Severe Vitreomacular Traction Syndrome without Functional Damage Demonstrated by Optical Coherence Tomography
Aqueye optical observations of the Crab Nebula pulsar
We observed the Crab pulsar in October 2008 at the Copernico Telescope in
Asiago - Cima Ekar with the optical photon counter Aqueye (the Asiago Quantum
Eye) which has the best temporal resolution and accuracy ever achieved in the
optical domain (hundreds of picoseconds). Our goal was to perform a detailed
analysis of the optical period and phase drift of the main peak of the Crab
pulsar and compare it with the Jodrell Bank ephemerides. We determined the
position of the main peak using the steepest zero of the cross-correlation
function between the pulsar signal and an accurate optical template. The pulsar
rotational period and period derivative have been measured with great accuracy
using observations covering only a 2 day time interval. The error on the period
is 1.7 ps, limited only by the statistical uncertainty. Both the rotational
frequency and its first derivative are in agreement with those from the Jodrell
Bank radio ephemerides archive. We also found evidence of the optical peak
leading the radio one by ~230 microseconds. The distribution of phase-residuals
of the whole dataset is slightly wider than that of a synthetic signal
generated as a sequence of pulses distributed in time with the probability
proportional to the pulse shape, such as the average count rate and background
level are those of the Crab pulsar observed with Aqueye. The counting
statistics and quality of the data allowed us to determine the pulsar period
and period derivative with great accuracy in 2 days only. The time of arrival
of the optical peak of the Crab pulsar leads the radio one in agreement with
what recently reported in the literature. The distribution of the phase
residuals can be approximated with a Gaussian and is consistent with being
completely caused by photon noise (for the best data sets).Comment: 7 pages, 7 figures. Accepted for publication in Astronomy and
Astrophysic
Classification of non-indigenous species based on their impacts: Considerations for application in marine management
Assessment of the ecological and economic/societal impacts of the introduction of non-indigenous species (NIS) is one of the primary focus areas of bioinvasion science in terrestrial and aquatic environments, and is considered essential to management. A classification system of NIS, based on the magnitude of their environmental impacts, was recently proposed to assist management. Here, we consider the potential application of this classification scheme to the marine environment, and offer a complementary framework focussing on value sets in order to explicitly address marine management concerns. Since existing data on marine NIS impacts are scarce and successful marine removals are rare, we propose that management of marine NIS adopt a precautionary approach, which not only would emphasise preventing new incursions through pre-border and at-border controls but also should influence the categorisation of impacts. The study of marine invasion impacts requires urgent attention and significant investment, since we lack the luxury of waiting for the knowledge base to be acquired before the window of opportunity closes for feasible management
The enlargement of the Suez Canal and introduction of non-indigenous species to the Mediterranean Sea
The Suez Canal is one of the most important waterways in the world – during the last year 17,148 ships passed through the Canal – reducing emissions, saving time, and operating costs to shippers. The rapid increase in ship size from the “Post-Suezmax” (> 12,000 TEU) to the latest container vessels (> 19,000 TEU) now requires enlargements of port facilities and canals.
A project of this magnitude, and with potentially negative environmental outcomes, requires a transparent and scientifically sound “Environmental Impact Assessment” (EIA). An explicit obligation on Parties to the Convention on Biological Diversity (https://www.cbd.int/doc/ legal/cbd-en.pdf) was made to consider transboundary impacts on biodiversity, particularly those associated with invasive non-indigenous species
Water-gated organic transistors on polyethylene naphthalate films
Water-gated organic transistors have been successfully exploited as potentiometric transducers in a variety of sensing applications. The device response does not depend exclusively on the intrinsic properties of the active materials, as the substrate and the device interfaces play a central role. It is therefore important to fine-tune the choice of materials and layout in order to optimize the final device performance. Here, polyethylene naphthalate (PEN) has been chosen as the reference substrate to fabricate and test flexible transistors as bioelectronic transducers in liquid. PEN is a biocompatible substrate that fulfills the requirements for both bio-applications and micro-fabrication technology.Three different semiconducting or conducting polymer thin films employing pentacene, poly(3-hexylthiophene) or poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) were compared in terms of transconductance, potentiometric sensitivity and response time. The different results allow us to identify material properties crucial for the optimization of organic transistor-based transducers operating in water
Bioactive triterpenes of protium heptaphyllum gum resin extract display cholesterol-lowering potential
Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra- and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds
Bioactive triterpenes of protium heptaphyllum gum resin extract display cholesterol-lowering potential
Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra-and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds
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