An infrared diagnostic for magnetism in hot stars

Magnetospheric observational proxies are used for indirect detection of magnetic fields in hot stars in the X-ray, UV, optical, and radio wavelength ranges. To determine the viability of infrared (IR) hydrogen recombination lines as a magnetic diagnostic for these stars, we have obtained low-resolution (R~1200), near-IR spectra of the known magnetic B2V stars HR 5907 and HR 7355, taken with the Ohio State Infrared Imager/Spectrometer (OSIRIS) attached to the 4.1m Southern Astrophysical Research (SOAR) Telescope. Both stars show definite variable emission features in IR hydrogen lines of the Brackett series, with similar properties as those found in optical spectra, including the derived location of the detected magnetospheric plasma. These features also have the added advantage of a lowered contribution of stellar flux at these wavelengths, making circumstellar material more easily detectable. IR diagnostics will be useful for the future study of magnetic hot stars, to detect and analyze lower-density environments, and to detect magnetic candidates in areas obscured from UV and optical observations, increasing the number of known magnetic stars to determine basic formation properties and investigate the origin of their magnetic fields.Comment: 4 pages, accepted for publication in A&

Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma

BACKGROUND Overexpression of heat shock proteins (HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma (EAC), it would be valuable to find new biomarkers for the development of cancer treatments. AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC. METHODS Immunohislochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EAC between 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival. RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression (P = 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo (P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3 (CI: 1.6-6.6, P = 0.001) and 2.2 (CI: 1.2-3.9, P = 0.02), respectively. CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time.Peer reviewe

STEREO observations of stars and the search for exoplanets

The feasibility of using data from the NASA STEREO mission for variable star and asteroseismology studies has been examined. A data analysis pipeline has been developed that is able to apply selected algorithms to the entire data base of nearly a million stars to search for signs of variability. An analysis limited to stars of magnitude 10.5 has been carried out, which has resulted in the extraction of 263 eclipsing binaries (EBs), of which 122 are not recorded as such in the SIMBAD online data base. The characteristics of the STEREO observations are shown to be extremely well suited to variable star studies with the ability to provide continuous phase coverage for extended periods as well as repeated visits that allow both short- and long-term variability to be observed. This will greatly inform studies of particular stars, such as the pre-cataclysmic variable V471 Tau, as well as the entire classes of stars, including many forms of rotational variability. The high-precision photometry has also revealed a potentially substellar companion to a bright (R= 7.5 mag) nearby star (HD 213597), detected with 5σ significance. This would provide a significant contribution to the exoplanet research if follow-up observations ascertain the mass to be within the planetary domain. Some particularly unusual EBs from the recovered sample are discussed, including a possible reclassification of a well-known star as an EB rather than a rotational variable (HR 7355) and several particularly eccentric systems, including very long period EBs

Studying the photometric and spectroscopic variability of the magnetic hot supergiant ζ\zeta Orionis Aa

Massive stars play a significant role in the chemical and dynamical evolution of galaxies. However, much of their variability, particularly during their evolved supergiant stage, is poorly understood. To understand the variability of evolved massive stars in more detail, we present a study of the O9.2Ib supergiant $\zeta$ Ori Aa, the only currently confirmed supergiant to host a magnetic field. We have obtained two-color space-based BRIght Target Explorer photometry (BRITE) for $\zeta$ Ori Aa during two observing campaigns, as well as simultaneous ground-based, high-resolution optical CHIRON spectroscopy. We perform a detailed frequency analysis to detect and characterize the star's periodic variability. We detect two significant, independent frequencies, their higher harmonics, and combination frequencies: the stellar rotation period $P_{\mathrm{rot}} = 6.82\pm0.18$ d, most likely related to the presence of the stable magnetic poles, and a variation with a period of $10.0\pm0.3$ d attributed to circumstellar environment, also detected in the H$\alpha$ and several He I lines, yet absent in the purely photospheric lines. We confirm the variability with $P_{\mathrm{rot}}$/4, likely caused by surface inhomogeneities, being the possible photospheric drivers of the discrete absorption components. No stellar pulsations were detected in the data. The level of circumstellar activity clearly differs between the two BRITE observing campaigns. We demonstrate that $\zeta$ Ori Aa is a highly variable star with both periodic and non-periodic variations, as well as episodic events. The rotation period we determined agrees well with the spectropolarimetric value from the literature. The changing activity level observed with BRITE could explain why the rotational modulation of the magnetic measurements was not clearly detected at all epochs.Comment: 20 pages, 5 tables, 12 figures, accepted for publication in A&

The MiMeS Project: Overview and Current Status

The Magnetism in Massive Stars (MiMeS) Project is a consensus collaboration among many of the foremost international researchers of the physics of hot, massive stars, with the basic aim of understanding the origin, evolution and impact of magnetic fields in these objects. At the time of writing, MiMeS Large Programs have acquired over 950 high-resolution polarised spectra of about 150 individual stars with spectral types from B5-O4, discovering new magnetic fields in a dozen hot, massive stars. The quality of this spectral and magnetic mat\'eriel is very high, and the Collaboration is keen to connect with colleagues capable of exploiting the data in new or unforeseen ways. In this paper we review the structure of the MiMeS observing programs and report the status of observations, data modeling and development of related theory.Comment: Proceedings of IAUS272: Active OB star

A Magnetic Confinement Versus Rotation Classification Of Massive-Star Magnetospheres

Building on results from the Magnetism in Massive Stars (MiMeS) project, this paper shows how a two-parameter classification of massive-star magnetospheres in terms of the magnetic wind confinement (which sets the Alfvén radius RA) and stellar rotation (which sets the Kepler co-rotation radius RK) provides a useful organization of both observational signatures and theoretical predictions. We compile the first comprehensive study of inferred and observed values for relevant stellar and magnetic parameters of 64 confirmed magnetic OB stars with Teff ≳ 16 kK. Using these parameters, we locate the stars in the magnetic confinement–rotation diagram, a log–log plot of RK versus RA. This diagram can be subdivided into regimes of centrifugal magnetospheres (CM), with RA \u3e RK, versus dynamical magnetospheres (DM), with RK \u3e RA. We show how key observational diagnostics, like the presence and characteristics of Hα emission, depend on a star\u27s position within the diagram, as well as other parameters, especially the expected wind mass-loss rates. In particular, we identify two distinct populations of magnetic stars with Hα emission: namely, slowly rotating O-type stars with narrow emission consistent with a DM, and more rapidly rotating B-type stars with broader emission associated with a CM. For O-type stars, the high mass-loss rates are sufficient to accumulate enough material for line emission even within the relatively short free-fall time-scale associated with a DM: this high mass-loss rate also leads to a rapid magnetic spindown of the stellar rotation. For the B-type stars, the longer confinement of a CM is required to accumulate sufficient emitting material from their relatively weak winds, which also lead to much longer spindown time-scales. Finally, we discuss how other observational diagnostics, e.g. variability of UV wind lines or X-ray emission, relate to the inferred magnetic properties of these stars, and summarize prospects for future developments in our understanding of massive-star magnetospheres

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid

Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment with the antioxidant alpha-lipoic acid (LA). Methods: Cultured ONH astrocytes were treated with 1.0 ng/ml TGF-beta(2) for 24 h or 200 mu M hydrogen peroxide (H2O2) for 1 h. Lipid peroxidation was measured by a decrease in cis-pari-naric acid fluorescence. Additionally, cells were pretreated with different concentrations of LA before TGF-beta 2 or H2O2 exposure. Expressions of the heat shock protein (Hsp) alpha B-crystallin and Hsp27, the extracellular matrix (ECM) component fibronectin and the ECM-modulating protein connective tissue growth factor (CTGF) were examined with immunohistochemistry and real-time PCR analysis. Results: Both TGF-beta(2) and H2O2 increased lipid peroxidation. Treatment of astrocytes with TGF-beta(2) and H2O2 upregulated the expression of alpha B-crystallin, Hsp27, fibronectin and CTGF. Pretreatment with different concentrations of LA reduced the TGF-beta(2)- and H2O2-stimulated gene expressions. Conclusion: We showed that TGF-beta(2)- and H2O2-stimulated gene expressions could be prevented by pretreatment with the antioxidant LA in cultured human ONH astrocytes. Therefore, it is tempting to speculate that the use of antioxidants could have protective effects in glaucomatous optic neuropathy. Copyright (C) 2012 S. Karger AG, Base

First HARPSpol discoveries of magnetic fields in massive stars

In the framework of the Magnetism in Massive Stars (MiMeS) project, a HARPSpol Large Program at the 3.6m-ESO telescope has recently started to collect high-resolution spectropolarimetric data of a large number of Southern massive OB stars in the field of the Galaxy and in many young clusters and associations. In this Letter, we report on the first discoveries of magnetic fields in two massive stars with HARPSpol - HD 130807 and HD 122451, and confirm the presence of a magnetic field at the surface of HD 105382 that was previously observed with a low spectral resolution device. The longitudinal magnetic field measurements are strongly varying for HD 130807 from $\sim$-100 G to $\sim$700 G. Those of HD 122451 and HD 105382 are less variable with values ranging from $\sim$-40 to -80 G, and from $\sim$-300 to -600 G, respectively. The discovery and confirmation of three new magnetic massive stars, including at least two He-weak stars, is an important contribution to one of the MiMeS objectives: the understanding of origin of magnetic fields in massive stars and their impacts on stellar structure and evolution.Comment: 4 pages, 2 figures, accepted for publication in A&A Lette

Clumpy molecular structures revolving the B[e] supergiant MWC 137

The peculiar emission-line star MWC 137 with its extended optical nebulawas recently classified as B[e] supergiant. To study the spatialdistribution of its circumstellar molecular gas on small and largescales, we obtained near-infrared and radio observations using SINFONIand APEX, respectively. We find that the hot CO gas is arranged inmoving clumpy ring and shell structures close to the star, while a coldCO envelope is encircling the borders of the optical nebula from thesouth to the west.Fil: Kraus, M.. Astronomický ústav; República ChecaFil: Cidale, Lydia Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Liimets, T.. Tartu Observatory; EstoniaFil: Cappa, Cristina Elisabeth. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Duronea, Nicolas Urbano. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Gunawan, Diah S.. Universidad de Valparaíso; ChileFil: Oksala, M. E.. Observatoire de Paris; FranciaFil: Santander García, M.. Instituto de Ciencia de Materiales de Madrid (CSIC); EspañaFil: Arias, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Nickeler, Dieter H.. Astronomický ústav; República ChecaFil: Maravelias, G.. Astronomický ústav; República ChecaFil: Borges Fernandes, M.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Curé, Michel. Universidad de Valparaíso; Chil

Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death

<p>Abstract</p> <p>Background</p> <p>Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcription factor 2 (SREBF-2) and the SREBF cleavage-activating protein (SCAP). We investigated whole genome expression in a series of human atherosclerotic samples from different vascular territories and studied whether the non-synonymous coding variants in the interacting domains of two genes, <it>SREBF-2 </it>1784G>C (rs2228314) and <it>SCAP </it>2386A>G, are related to the progression of coronary atherosclerosis and the risk of pre-hospital sudden cardiac death (SCD).</p> <p>Methods</p> <p>Whole genome expression profiling was completed in twenty vascular samples from carotid, aortic and femoral atherosclerotic plaques and six control samples from internal mammary arteries. Three hundred sudden pre-hospital deaths of middle-aged (33–69 years) Caucasian Finnish men were subjected to detailed autopsy in the Helsinki Sudden Death Study. Coronary narrowing and areas of coronary wall covered with fatty streaks or fibrotic, calcified or complicated lesions were measured and related to the <it>SREBF-2 </it>and <it>SCAP </it>genotypes.</p> <p>Results</p> <p>Whole genome expression profiling showed a significant (p = 0.02) down-regulation of <it>SREBF-2 </it>in atherosclerotic carotid plaques (types IV-V), but not in the aorta or femoral arteries (p = NS for both), as compared with the histologically confirmed non-atherosclerotic tissues. In logistic regression analysis, a significant interaction between the <it>SREBF-2 </it>1784G>C and the <it>SCAP </it>2386A>G genotype was observed on the risk of SCD (p = 0.046). Men with the <it>SREBF-2 </it>C allele and the <it>SCAP </it>G allele had a significantly increased risk of SCD (OR 2.68, 95% CI 1.07–6.71), compared to <it>SCAP </it>AA homologous subjects carrying the <it>SREBF-2 </it>C allele. Furthermore, similar trends for having complicated lesions and for the occurrence of thrombosis were found, although the results were not statistically significant.</p> <p>Conclusion</p> <p>The results suggest that the allelic variants (<it>SREBF-2 </it>1784G>C and <it>SCAP </it>2386A>G) in the cholesterol homeostasis regulating SREBF-SCAP pathway may contribute to SCD in early middle-aged men.</p