Not Another Cuba: Lyndon Johnson and the Dominican Republic, 1956-66

This Honors Thesis will examine President Lyndon Johnson\u27s foreign policy surrounding America\u27s complex diplomatic relationship with the Dominican Republic throughout the 1960s. Regarded throughout the last few decades as a less dramatic or telegenic study, the Johnson administration\u27s involvement in the Dominican Republic has been largely overlooked and forgotten. In the wake of an emerging third generation of scholarship, historians are now beginning to uncover the intricate entanglement of information and circumstances supporting Johnson\u27s role in establishing the parameters of U.S. Policy. At the heart of this discussion exists a robust argument currently taking place among scholars who debate the efficaciousness of Johnson and his staff in regards to foreign policy decisions. In no such theater of American influence is the current argument more heated than Johnson\u27s approach in the Dominican Republic. Reviewing the scope of recent scholarship available (including the works of Peter Felten and Randall B. Woods, among others), this Honors Thesis will seek and defend a definitive position concerning the conclusive success or failure of the Johnson administration in the Dominican Republic

Raman fingerprints on the Bloch sphere of a spinor Bose-Einstein condensate

We explore the geometric interpretation of a diabatic, two-photon Raman process as a rotation on the Bloch sphere for a pseudo-spin-1/2 system. The spin state of a spin-1/2 quantum system can be described by a point on the surface of the Bloch sphere, and its evolution during a Raman pulse is a trajectory on the sphere determined by properties of the optical beams: the pulse area, the relative intensities and phases, and the relative frequencies. We experimentally demonstrate key features of this model with a $^{87}$Rb spinor Bose-Einstein condensate, which allows us to examine spatially dependent signatures of the Raman beams. The two-photon detuning allows us to precisely control the spin density and imprinted relative phase profiles, as we show with a coreless vortex. With this comprehensive understanding and intuitive geometric interpretation, we use the Raman process to create and tailor as well as study and characterize exotic topological spin textures in spinor BECs.Comment: 13 pages, 13 figures, submitted to the Journal of Modern Optics "20 Years of Bose-Einstein condensates" Special Issu

Speckle techniques for determining stresses in moving objects

Laser speckle interferometry is a relatively new experimental technique which shows promise of alleviating many difficult problems in experimental mechanics. The method utilizes simple high-resolution photographs of the surface which is illuminated by coherent light. The result is a real-time or permanently stored whole-field record of interference fringes which yields a map of displacements in the object. In this thesis, the time-average theory using the Fourier transform is developed to present the application of this technique to measurement of in-plane displacement induced by the vibration of an object

Topological atom optics and beyond with knotted quantum wavefunctions

Atom optics demonstrates optical phenomena with coherent matter waves, providing a foundational connection between light and matter. Significant advances in optics have followed the realization of structured light fields hosting complex singularities and topologically non-trivial characteristics. However, analogous studies are still in their infancy in the field of atom optics. Here, we investigate and experimentally create knotted quantum wavefunctions in spinor Bose–Einstein condensates which display non-trivial topologies. In our work we construct coordinated orbital and spin rotations of the atomic wavefunction, engineering a variety of discrete symmetries in the combined spin and orbital degrees of freedom. The structured wavefunctions that we create map to the surface of a torus to form torus knots, Möbius strips, and a twice-linked Solomon’s knot. In this paper we demonstrate close connections between the symmetries and underlying topologies of multicomponent atomic systems and of vector optical fields—a realization of topological atom-optics

Amino Acids Are an Ineffective Fertilizer for Dunaliella spp. Growth

Autotrophic microalgae are a promising bioproducts platform. However, the fundamental requirements these organisms have for nitrogen fertilizer severely limit the impact and scale of their cultivation. As an alternative to inorganic fertilizers, we investigated the possibility of using amino acids from deconstructed biomass as a nitrogen source in the genus Dunaliella. We found that only four amino acids (glutamine, histidine, cysteine, and tryptophan) rescue Dunaliella spp. growth in nitrogen depleted media, and that supplementation of these amino acids altered the metabolic profile of Dunaliella cells. Our investigations revealed that histidine is transported across the cell membrane, and that glutamine and cysteine are not transported. Rather, glutamine, cysteine, and tryptophan are degraded in solution by a set of oxidative chemical reactions, releasing ammonium that in turn supports growth. Utilization of biomass-derived amino acids is therefore not a suitable option unless additional amino acid nitrogen uptake is enabled through genetic modifications of these algae

Towards informed and multi-faceted wildlife trade interventions

International trade in wildlife is a key threat to biodiversity conservation. CITES, the Convention on International Trade in Endangered Species of Wild Fauna and Flora, is the primary mechanism for controlling international wildlife trade and seeks to ensure it is sustainable, relying on trade bans and controls. However, there has been little comprehensive review of the effectiveness of CITES. Here, we review typical and atypical approaches taken to regulate wildlife trade in CITES and assert that it boasts few successes. We attribute this to: non-compliance, an over reliance on regulation, lack of knowledge of listed species, ignorance of the reality of market forces, and influence among CITES actors. To more effectively manage trade we argue that interventions need to go beyond regulation and should be multi-faceted, reflecting the complexity of wildlife trade. To inform such interventions we assert an intensive research effort is needed and we outline six key research areas: (1) factors undermining wildlife trade governance at the national level, (2) determining sustainable harvest rates for CITES species, (3) gaining the buy-in of local communities in implementing CITES, (4) supply and demand based market interventions, (5) means of quantifying illicit trade, and (6) political processes and influence within CITES

Retinoblastoma

Retinoblastoma is a rare eye tumor of childhood that arises in the retina. It is the most common intraocular malignancy of infancy and childhood; with an incidence of 1/15,000–20,000 live births. The two most frequent symptoms revealing retinoblastoma are leukocoria and strabismus. Iris rubeosis, hypopyon, hyphema, buphthalmia, orbital cellulites and exophthalmia may also be observed. Sixty per cent of retinoblastomas are unilateral and most of these forms are not hereditary (median age at diagnosis two years). Retinoblastoma is bilateral in 40% of cases (median age at diagnosis one year). All bilateral and multifocal unilateral forms are hereditary. Hereditary retinoblastoma constitutes a cancer predisposition syndrome: a subject constitutionally carrying an RB1 gene mutation has a greater than 90% risk of developing retinoblastoma but is also at increased risk of developing other types of cancers. Diagnosis is made by fundoscopy. Ultrasound, magnetic resonance imaging (MRI) and computed tomography (CT) scans may contribute to diagnosis. Management of patients with retinoblastoma must take into account the various aspects of the disease: the visual risk, the possibly hereditary nature of the disease, the life-threatening risk. Enucleation is still often necessary in unilateral disease; the decision for adjuvant treatment is taken according to the histological risk factors. Conservative treatment for at least one eye is possible in most of the bilateral cases. It includes laser alone or combined with chemotherapy, cryotherapy and brachytherapy. The indication for external beam radiotherapy should be restricted to large ocular tumors and diffuse vitreous seeding because of the risk of late effects, including secondary sarcoma. Vital prognosis, related to retinoblastoma alone, is now excellent in patients with unilateral or bilateral forms of retinoblastoma. Long term follow-up and early counseling regarding the risk of second primary tumors and transmission should be offered to retinoblastoma patients

Broad-line region in NGC 4151 monitored by two decades of reverberation mapping campaigns. I. Evolution of structure and kinematics

We report the results of long-term reverberation mapping (RM) campaigns of the nearby active galactic nuclei (AGN) NGC 4151, spanning from 1994 to 2022, based on archived observations of the FAST Spectrograph Publicly Archived Programs and our new observations with the 2.3m telescope at the Wyoming Infrared Observatory. We reduce and calibrate all the spectra in a consistent way, and derive light curves of the broad H$\beta$ line and 5100\,{\AA} continuum. Continuum light curves are also constructed using public archival photometric data to increase sampling cadences. We subtract the host galaxy contamination using {\it HST} imaging to correct fluxes of the calibrated light curves. Utilizing the long-term archival photometric data, we complete the absolute flux-calibration of the AGN continuum. We find that the H$\beta$ time delays are correlated with the 5100\,{\AA} luminosities as $\tau_{\rm H\beta}\propto L_{5100}^{0.46\pm0.16}$. This is remarkably consistent with Bentz et al. (2013)'s global size-luminosity relationship of AGNs. Moreover, the data sets for five of the seasons allow us to obtain the velocity-resolved delays of the H$\beta$ line, showing diverse structures (outflows, inflows and disks). Combining our results with previous independent measurements, we find the measured dynamics of the H$\beta$ broad-line region (BLR) are possibly related to the long-term trend of the luminosity. There is also a possible additional $\sim$1.86 years time lag between the variation in BLR radius and luminosity. These results suggest that dynamical changes in the BLR may be driven by the effects of radiation pressure.Comment: Accepted for publication in MNRAS; comments welcome

First results from the JWST Early Release Science Program Q3D: Benchmark Comparison of Optical and Mid-IR Tracers of a Dusty, Ionized Red Quasar Wind at z=0.435

The [OIII] 5007 A emission line is the most common tracer of warm, ionized outflows in active galactic nuclei across cosmic time. JWST newly allows us to use mid-infrared spectral features at both high spatial and spectral resolution to probe these same winds. Here we present a comparison of ground-based, seeing-limited [OIII] and space-based, diffraction-limited [SIV] 10.51 micron maps of the powerful, kpc-scale outflow in the Type 1 red quasar SDSS J110648.32+480712.3. The JWST data are from the Mid-InfraRed Instrument (MIRI). There is a close match in resolution between the datasets (0."4--0."6), in ionization potential of the O+2 and S+3 ions (35 eV), and in line sensitivity (1e-17 to 2e-17 erg/s/cm2/arcsec2). The [OIII] and [SIV] line shapes match in velocity and linewidth over much of the 20 kpc outflowing nebula, and [SIV] is the brightest line in the rest-frame 3.5--19.5 micron range, demonstrating its usefulness as a mid-IR probe of quasar outflows. [OIII] is nevertheless intriniscally brighter and provides better contrast with the point-source continuum, which is strong in the mid-IR. There is a strong anticorrelation of [OIII]/[SIV] with average velocity, which is consistent with a scenario of differential obscuration between the approaching (blueshifted) and receding (redshifted) sides of the flow. The dust in the wind may also obscure the central quasar, consistent with models that attribute red quasar extinction to dusty winds.Comment: Submitted to ApJ

Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation

<p>Abstract</p> <p>Background</p> <p>Lung ischemia-reperfusion (IR) injury leads to significant morbidity and mortality which remains a major obstacle after lung transplantation. However, the role of various subset(s) of lung cell populations in the pathogenesis of lung IR injury and the mechanisms of cellular protection remain to be elucidated. In the present study, we investigated the effects of adenosine A_2Areceptor (A_2AAR) activation on resident lung cells after IR injury using an isolated, buffer-perfused murine lung model.</p> <p>Methods</p> <p>To assess the protective effects of A_2AAR activation, three groups of C57BL/6J mice were studied: a sham group (perfused for 2 hr with no ischemia), an IR group (1 hr ischemia + 1 hr reperfusion) and an IR+ATL313 group where ATL313, a specific A_2AAR agonist, was included in the reperfusion buffer after ischemia. Lung injury parameters and pulmonary function studies were also performed after IR injury in A_2AAR knockout mice, with or without ATL313 pretreatment. Lung function was assessed using a buffer-perfused isolated lung system. Lung injury was measured by assessing lung edema, vascular permeability, cytokine/chemokine activation and myeloperoxidase levels in the bronchoalveolar fluid.</p> <p>Results</p> <p>After IR, lungs from C57BL/6J wild-type mice displayed significant dysfunction (increased airway resistance, pulmonary artery pressure and decreased pulmonary compliance) and significant injury (increased vascular permeability and edema). Lung injury and dysfunction after IR were significantly attenuated by ATL313 treatment. Significant induction of TNF-α, KC (CXCL1), MIP-2 (CXCL2) and RANTES (CCL5) occurred after IR which was also attenuated by ATL313 treatment. Lungs from A_2AAR knockout mice also displayed significant dysfunction, injury and cytokine/chemokine production after IR, but ATL313 had no effect in these mice.</p> <p>Conclusion</p> <p>Specific activation of A_2AARs provides potent protection against lung IR injury via attenuation of inflammation. This protection occurs in the absence of circulating blood thereby indicating a protective role of A_2AAR activation on resident lung cells such as alveolar macrophages. Specific A_2AAR activation may be a promising therapeutic target for the prevention or treatment of pulmonary graft dysfunction in transplant patients.</p